PMID- 33443639
OWN - NLM
STAT- MEDLINE
DCOM- 20220502
LR  - 20220502
IS  - 0975-0711 (Electronic)
IS  - 0254-8860 (Linking)
VI  - 40
IP  - 6
DP  - 2021 Dec
TI  - Diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration of 
      tubercular lymphadenitis using combination of cytology and Gene Xpert 
      Mycobacterium tuberculosis/rifampicin (MTB/RIF) genes.
PG  - 630-635
LID - 10.1007/s12664-020-01136-6 [doi]
AB  - Diagnostic yield of an automated molecular test, Gene Xpert Mycobacterium 
      tuberculosis/rifampicin (MTB/RIF), was evaluated in this study to simultaneously 
      detect the MTB gene and resistance to rifampicin (RIF) on cytology samples 
      acquired via endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNAC) in 
      suspected tubercular lymphadenitis. Microscopy, cytology, Gene Xpert MTB/RIF 
      assay data on Acid-fast bacillus (AFB), and traditional culture of lymph nodes 
      were retrospectively analyzed. Thirty-one patients (median age 33.5 years, 
      inter-quartile range [IQR] 21-66, 18, 58% female) presented with fever (28, 90%), 
      dysphagia (2, 7%), and recurrent subacute intestinal obstruction (1, 3%). Gene 
      Xpert showed higher sensitivity (30, 97%) compared to the other tests: cytology 
      (23, 77%; odds ratio [OR] 8.8, 95% confidence interval [CI] 1.0-76.9; p = 0.05), 
      AFB smears (12, 39%; OR 50, 95% CI 5.9-420.4; p = 0.00001), and conventional 
      culture (4, 13%; OR 188.5, 95% CI 19.7-1796.3; p = 0.0000). We conclude that Gene 
      Xpert MTB/RIF test on EUS-guided FNAC samples is very useful to diagnose 
      tubercular lymphadenitis.
CI  - (c) 2021. Indian Society of Gastroenterology.
FAU - Mohindra, Samir
AU  - Mohindra S
AUID- ORCID: 0000-0002-1638-5721
AD  - Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226 014, India. mohindrasamir@yahoo.com.
FAU - Nayak, Hemanta Kumar
AU  - Nayak HK
AD  - Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226 014, India.
FAU - Mohindra, Namita
AU  - Mohindra N
AD  - Department of Radiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226 014, India.
FAU - Kumar, Alok
AU  - Kumar A
AD  - Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226 014, India.
AD  - Department of Pulmonary Medicine, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Lucknow, 226 014, India.
FAU - Saraswat, Vivek Anand
AU  - Saraswat VA
AD  - Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226 014, India.
FAU - Kumari, Niraj
AU  - Kumari N
AD  - Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226 014, India.
FAU - Misra, Richa
AU  - Misra R
AD  - Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226 014, India.
FAU - Ghoshal, Uday C
AU  - Ghoshal UC
AD  - Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical 
      Sciences, Raebareli Road, Lucknow, 226 014, India.
LA  - eng
PT  - Journal Article
DEP - 20210114
PL  - India
TA  - Indian J Gastroenterol
JT  - Indian journal of gastroenterology : official journal of the Indian Society of 
      Gastroenterology
JID - 8409436
RN  - VJT6J7R4TR (Rifampin)
SB  - IM
CIN - Indian J Gastroenterol. 2021 Dec;40(6):551-555. PMID: 35076892
MH  - Adult
MH  - Drug Resistance, Bacterial/genetics
MH  - Endoscopic Ultrasound-Guided Fine Needle Aspiration
MH  - Female
MH  - Humans
MH  - *Lymphadenitis
MH  - Male
MH  - *Mycobacterium tuberculosis/genetics
MH  - Retrospective Studies
MH  - Rifampin
MH  - Sensitivity and Specificity
MH  - *Tuberculosis, Lymph Node/diagnosis/microbiology/pathology
OTO - NOTNLM
OT  - Acid-fast bacillus
OT  - Acquired immunodeficiency syndrome
OT  - Anti-tubercular treatment
OT  - Drug-resistant tuberculosis
OT  - Mediastinum
OT  - Pyrexia
OT  - Tuberculosis
OT  - Ziehl-Neelsen (ZN) stain
EDAT- 2021/01/15 06:00
MHDA- 2022/05/03 06:00
CRDT- 2021/01/14 12:11
PHST- 2020/11/23 00:00 [received]
PHST- 2020/12/03 00:00 [accepted]
PHST- 2021/01/15 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2021/01/14 12:11 [entrez]
AID - 10.1007/s12664-020-01136-6 [pii]
AID - 10.1007/s12664-020-01136-6 [doi]
PST - ppublish
SO  - Indian J Gastroenterol. 2021 Dec;40(6):630-635. doi: 10.1007/s12664-020-01136-6. 
      Epub 2021 Jan 14.