PMID- 33444119
OWN - NLM
STAT- MEDLINE
DCOM- 20210629
LR  - 20210924
IS  - 1522-1601 (Electronic)
IS  - 0161-7567 (Linking)
VI  - 130
IP  - 3
DP  - 2021 Mar 1
TI  - Negligible influence of moderate to severe hyperthermia on blood-brain barrier 
      permeability and neuronal parenchymal integrity in healthy men.
PG  - 792-800
LID - 10.1152/japplphysiol.00645.2020 [doi]
AB  - With growing use for hyperthermia as a cardiovascular therapeutic, there is 
      surprisingly little information regarding the acute effects it may have on the 
      integrity of the neurovascular unit (NVU). Indeed, relying on animal data would 
      suggest hyperthermia comparable to levels attained in thermal therapy will 
      disrupt the blood-brain barrier (BBB) and damage the cerebral parenchymal cells. 
      We sought to address the hypothesis that controlled passive hyperthermia is not 
      sufficient to damage the NVU in healthy humans. Young men (n = 11) underwent 
      acute passive heating until +2 degrees C or absolute esophageal temperature of 39.5 degrees C. 
      The presence of BBB opening was determined by trans-cerebral exchange kinetics 
      (radial-arterial and jugular venous cannulation) of S100B. Neuronal parenchymal 
      damage was determined by the trans-cerebral exchange of tau protein, 
      neuron-specific enolase (NSE), and neurofilament-light protein (NF-L). Cerebral 
      blood flow to calculate exchange kinetics was measured by duplex ultrasound of 
      the right internal carotid and left vertebral artery. Passive heating was 
      performed via a warm-water perfused suit. In hyperthermia, there was no increase 
      in the cerebral exchange of S100B (P = 0.327), tau protein (P = 0.626), NF-L (P = 
      0.447), or NSE (P = 0.908) suggesting the +2 degrees C core temperature is not sufficient 
      to acutely stress the NVU in healthy men. However, there was a significant 
      condition effect (P = 0.028) of NSE, corresponding to a significant increase in 
      arterial (P = 0.023) but not venous (P = 0.173) concentrations in hyperthermia, 
      potentially indicating extra-cerebral release of NSE. Collectively, results from 
      the present study support the notion that in young men there is little concern 
      for NVU damage with acute hyperthermia of +2  degrees C.NEW & NOTEWORTHY The acute 
      effects of passive whole-body hyperthermia on the integrity of the neurovascular 
      unit (NVU) in humans have remained unclear. We demonstrate that passive heating 
      for  approximately 1 h until an increase of +2 degrees C esophageal temperature in healthy men does not 
      increase the cerebral release of neuronal parenchymal stress biomarkers, 
      suggesting the NVU integrity is maintained. This preliminary study indicates 
      passive heating is safe for the brain, at least in young healthy men.
FAU - Shepley, Brooke R
AU  - Shepley BR
AD  - University of Windsor, Faculty of Human Kinetics, Department of Kinesiology, 
      Windsor, ON, Canada.
FAU - Ainslie, Philip N
AU  - Ainslie PN
AD  - University of British Columbia, Kelowna, Centre for Heart Lung and Vascular 
      Health, Vancouver, BC, Canada.
FAU - Hoiland, Ryan L
AU  - Hoiland RL
AUID- ORCID: 0000-0002-5657-0059
AD  - University of British Columbia, Kelowna, Centre for Heart Lung and Vascular 
      Health, Vancouver, BC, Canada.
AD  - Department of Anesthesiology, Pharmacology, and Therapeutics, Vancouver General 
      Hospital, Vancouver, BC, Canada.
FAU - Donnelly, Joseph
AU  - Donnelly J
AD  - Brain Physics Laboratory, Division of Academic Neurosurgery, Department of 
      Clinical Neurosciences, Addenbrookes Hospital, University of Cambridge, 
      Cambridge, UK.
FAU - Sekhon, Mypinder S
AU  - Sekhon MS
AD  - University of British Columbia, Kelowna, Centre for Heart Lung and Vascular 
      Health, Vancouver, BC, Canada.
AD  - Division of Critical Care Medicine and Department of Medicine, University of 
      British Columbia, Vancouver, BC, Canada.
FAU - Zetterberg, Henrik
AU  - Zetterberg H
AD  - Department of Psychiatry and Neurochemistry, Institute of Neuroscience and 
      Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal, 
      Sweden.
AD  - Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, 
      Sweden.
AD  - Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen 
      Square, London, UK.
AD  - UK Dementia Research Institute at UCL, London, UK.
FAU - Blennow, Kaj
AU  - Blennow K
AD  - Department of Psychiatry and Neurochemistry, Institute of Neuroscience and 
      Physiology, the Sahlgrenska Academy at the University of Gothenburg, Molndal, 
      Sweden.
AD  - Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, 
      Sweden.
FAU - Bain, Anthony R
AU  - Bain AR
AD  - University of Windsor, Faculty of Human Kinetics, Department of Kinesiology, 
      Windsor, ON, Canada.
LA  - eng
GR  - 681712/ERC_/European Research Council/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210114
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
SB  - IM
MH  - *Blood-Brain Barrier
MH  - Cerebrovascular Circulation
MH  - Humans
MH  - Hyperthermia
MH  - *Hyperthermia, Induced
MH  - Male
MH  - Permeability
OTO - NOTNLM
OT  - brain
OT  - heat stress
OT  - neurovascular unit
EDAT- 2021/01/15 06:00
MHDA- 2021/06/30 06:00
CRDT- 2021/01/14 17:09
PHST- 2021/01/15 06:00 [pubmed]
PHST- 2021/06/30 06:00 [medline]
PHST- 2021/01/14 17:09 [entrez]
AID - 10.1152/japplphysiol.00645.2020 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 2021 Mar 1;130(3):792-800. doi: 
      10.1152/japplphysiol.00645.2020. Epub 2021 Jan 14.