PMID- 33444711
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20220402
IS  - 1879-260X (Electronic)
IS  - 0925-4439 (Print)
IS  - 0925-4439 (Linking)
VI  - 1867
IP  - 4
DP  - 2021 Apr 1
TI  - The interaction between brain and liver regulates lipid metabolism in the TBI 
      pathology.
PG  - 166078
LID - S0925-4439(21)00011-9 [pii]
LID - 10.1016/j.bbadis.2021.166078 [doi]
AB  - To shed light on the impact of systemic physiology on the pathology of traumatic 
      brain injury (TBI), we examine the effects of TBI (concussive injury) and dietary 
      fructose on critical aspects of lipid homeostasis in the brain and liver of 
      young-adult rats. Lipids are integral components of brain structure and function, 
      and the liver has a role on the synthesis and metabolism of lipids. Fructose is 
      mainly metabolized in the liver with potential implications for brain function. 
      Lipidomic analysis accompanied by unbiased sparse partial least squares 
      discriminant analysis (sPLS-DA) identified lysophosphatidylcholine (LPC) and 
      cholesterol ester (CE) as the top lipid families impacted by TBI and fructose in 
      the hippocampus, and only LPC (16:0) was associated with hippocampal-dependent 
      memory performance. Fructose and TBI elevated liver pro-inflammatory markers, 
      interleukin-1alpha (IL-1alpha), Interferon-gamma (IFN-gamma) that correlated with 
      hippocampal-dependent memory dysfunction, and monocyte chemoattractant protein-1 
      (MCP-1) positively correlated with LPC levels in the hippocampus. The effects of 
      fructose were more pronounced in the liver, in agreement with the role of liver 
      on fructose metabolism and suggest that fructose could exacerbate liver 
      inflammation caused by TBI. The overall results indicate that TBI and fructose 
      interact to influence systemic and central inflammation by engaging liver lipids. 
      The impact of TBI and fructose diet on the periphery provides a therapeutic 
      target to counteract the TBI pathogenesis.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Palafox-Sanchez, Victoria
AU  - Palafox-Sanchez V
AD  - Department of Integrative Biology & Physiology, UCLA, Los Angeles, USA.
FAU - Ying, Zhe
AU  - Ying Z
AD  - Department of Integrative Biology & Physiology, UCLA, Los Angeles, USA.
FAU - Royes, Luiz Fernando Freire
AU  - Royes LFF
AD  - Department of Integrative Biology & Physiology, UCLA, Los Angeles, USA; Exercise 
      Biochemistry Laboratory, Center of Physical Education and Sports, Federal 
      University of Santa Maria - UFSM, Santa Maria, RS, Brazil.
FAU - Gomez-Pinilla, Fernando
AU  - Gomez-Pinilla F
AD  - Department of Integrative Biology & Physiology, UCLA, Los Angeles, USA; 
      Department of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, USA. 
      Electronic address: fgomezpi@ucla.edu.
LA  - eng
GR  - R01 NS050465/NS/NINDS NIH HHS/United States
GR  - R01 NS111378/NS/NINDS NIH HHS/United States
GR  - R01 NS117148/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210112
PL  - Netherlands
TA  - Biochim Biophys Acta Mol Basis Dis
JT  - Biochimica et biophysica acta. Molecular basis of disease
JID - 101731730
SB  - IM
MH  - Animals
MH  - Brain/metabolism/*physiopathology
MH  - Brain Injuries, Traumatic/metabolism/*physiopathology
MH  - Inflammation/metabolism/physiopathology
MH  - *Lipid Metabolism
MH  - Liver/metabolism/*physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
PMC - PMC7889047
MID - NIHMS1661977
OTO - NOTNLM
OT  - Cognition
OT  - Fructose
OT  - Liver
OT  - Lysophosphatidylcholine
OT  - Traumatic brain injury
OT  - cPLA2
COIS- Competing Interests Statement The authors declare no competing interests. 
      Declaration of interests The authors declare that they have no known competing 
      financial interests or personal relationships that could have appeared to 
      influence the work reported in this paper.
EDAT- 2021/01/15 06:00
MHDA- 2021/07/03 06:00
PMCR- 2022/04/01
CRDT- 2021/01/14 20:12
PHST- 2020/09/29 00:00 [received]
PHST- 2020/12/28 00:00 [revised]
PHST- 2021/01/03 00:00 [accepted]
PHST- 2021/01/15 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2021/01/14 20:12 [entrez]
PHST- 2022/04/01 00:00 [pmc-release]
AID - S0925-4439(21)00011-9 [pii]
AID - 10.1016/j.bbadis.2021.166078 [doi]
PST - ppublish
SO  - Biochim Biophys Acta Mol Basis Dis. 2021 Apr 1;1867(4):166078. doi: 
      10.1016/j.bbadis.2021.166078. Epub 2021 Jan 12.