PMID- 33445392
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210115
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 3
IP  - 12
DP  - 2017 Dec 11
TI  - Magnetic Resonance Imaging of Alginate Beads Containing Pancreatic Beta Cells and 
      Paramagnetic Nanoparticles.
PG  - 3576-3587
LID - 10.1021/acsbiomaterials.7b00404 [doi]
AB  - Microencapsulation is being investigated as a means to avoid rejection of 
      transplanted pancreatic islets. Monitoring bead distribution and stability in 
      vivo is an important step toward improving microencapsulated islet 
      transplantation strategies. Islet co-encapsulation with gadolinium-labeled 
      mesoporous silica nanoparticles (Gd-MSNs) could allow bead visualization while 
      immobilizing and limiting the potential internalization of the contrast agent. 
      The porous nature of the MSNs could also be used to locally release 
      anti-inflammatory, angiogenic, or anti-apoptotic factors. Mouse insulinoma 6 
      (MIN6) beta cells were co-encapsulated with Gd-MSNs in alginate beads produced by 
      emulsification and internal gelation. Gd-MSN alginate beads appeared brighter in 
      T(1)-weighted imaging sequences (detection threshold of 0.016 mM Gd; relaxometric 
      ratio r(2)/r(1) = 1.45) than beads without Gd-MSNs. No leaching of Gd(3+) from 
      the hydrogels was detected over the course of 3 months. MIN6 cells 
      co-encapsulated with Gd-MSNs were viable without significant differences in cell 
      growth rate compared to encapsulated controls without Gd-MSNs. This study paves 
      the way for microencapsulated islet tracking via MRI using co-encapsulated 
      paramagnetic nanomaterials.
FAU - Sarkis, Sary
AU  - Sarkis S
AD  - Department of Chemical Engineering, McGill University, Wong Building, 3610 
      University Street, Montreal, QC H3A 0C5, Canada.
FAU - Silencieux, Fanny
AU  - Silencieux F
AD  - Laboratoire de Biomateriaux pour l'Imagerie medicale, Axe Medecine Regeneratrice, 
      Centre de recherche du Centre hospitalier universitaire de Quebec (CR-CHU de 
      Quebec), 10 rue de l'Espinay, Quebec City, QC G1L 3L5, Canada.
AD  - Centre de recherche sur les materiaux avances (CERMA), Universite Laval, Pavillon 
      Vachon, 1065 avenue de la Medecine, Quebec City, QC G1V 0A6, Canada.
AD  - Departement de Genie des Mines, de la Metallurgie et des Materiaux, Universite 
      Laval, Pavillon Pouliot, 1065 avenue de la Medecine, Quebec City, QC G1V 0A6, 
      Canada.
FAU - Markwick, Karen E
AU  - Markwick KE
AD  - Department of Chemical Engineering, McGill University, Wong Building, 3610 
      University Street, Montreal, QC H3A 0C5, Canada.
FAU - Fortin, Marc-Andre
AU  - Fortin MA
AUID- ORCID: 0000-0002-8601-466X
AD  - Laboratoire de Biomateriaux pour l'Imagerie medicale, Axe Medecine Regeneratrice, 
      Centre de recherche du Centre hospitalier universitaire de Quebec (CR-CHU de 
      Quebec), 10 rue de l'Espinay, Quebec City, QC G1L 3L5, Canada.
AD  - Centre de recherche sur les materiaux avances (CERMA), Universite Laval, Pavillon 
      Vachon, 1065 avenue de la Medecine, Quebec City, QC G1V 0A6, Canada.
AD  - Departement de Genie des Mines, de la Metallurgie et des Materiaux, Universite 
      Laval, Pavillon Pouliot, 1065 avenue de la Medecine, Quebec City, QC G1V 0A6, 
      Canada.
FAU - Hoesli, Corinne A
AU  - Hoesli CA
AUID- ORCID: 0000-0002-5629-7128
AD  - Department of Chemical Engineering, McGill University, Wong Building, 3610 
      University Street, Montreal, QC H3A 0C5, Canada.
LA  - eng
PT  - Journal Article
DEP - 20171017
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - alginate beads
OT  - beta cell
OT  - islet encapsulation
OT  - magnetic resonance imaging
OT  - mesoporous silica nanoparticles
OT  - paramagnetic contrast agents
EDAT- 2017/12/11 00:00
MHDA- 2017/12/11 00:01
CRDT- 2021/01/15 01:00
PHST- 2021/01/15 01:00 [entrez]
PHST- 2017/12/11 00:00 [pubmed]
PHST- 2017/12/11 00:01 [medline]
AID - 10.1021/acsbiomaterials.7b00404 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2017 Dec 11;3(12):3576-3587. doi: 
      10.1021/acsbiomaterials.7b00404. Epub 2017 Oct 17.