PMID- 33447423
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 12
IP  - 12
DP  - 2020 Dec
TI  - Effects of enteral nutrition support combined with enhanced recovery after 
      surgery on the nutritional status, immune function, and prognosis of patients 
      with esophageal cancer after Ivor-Lewis operation.
PG  - 7337-7345
LID - 10.21037/jtd-20-3410 [doi]
AB  - BACKGROUND: Esophageal cancer (EC) with a high incidence of malnutrition is a 
      highly malignant digestive tract tumor. We investigated the effect of enteral 
      nutrition (EN) support combined with enhanced recovery after surgery (ERAS) on 
      the nutritional status, immune function, and prognosis of patients with EC after 
      Ivor-Lewis operation. METHODS: One hundred patients were randomly divided into 
      the observation group (n=42) and the control group (n=58). The patients in 
      observation group were treated with EN combined with ERAS intervention after 
      Ivor-Lewis operation, and the patients in control group were treated with 
      conventional postoperative EN intervention. The situation of operation, 
      nutritional status, immune function recovery and prognosis between the two groups 
      were compared. RESULTS: There was no statistically significant difference in 
      operation time or intraoperative blood loss between the two groups (P>0.05). The 
      chest tube removal time and oral feeding time of the observation group after 
      operation were shorter than those of the control group (P<0.05). After 
      intervention, serum albumin (ALB), transferrin (TF), pre-albumin (PA) and 
      hemoglobin (Hb) levels in both groups were significantly decreased. These indexes 
      were significantly higher in the observation group than in the control group 
      (P<0.05). There were no significant changes in the levels of immunoglobulin (Ig) 
      A, IgG, and IgM, or the numbers of CD3(+), CD4(+) and CD4(+)/CD8(+) T cells in 
      the observation group before and after intervention (P>0.05); however those 
      indexes were significantly decreased in the control group after the intervention 
      (P<0.05). Interestingly, the levels of IgA, IgM, IgG, CD3(+) T cells, CD4(+) T 
      cells and CD4(+)/CD8(+) T cells in the observation group were significantly 
      higher than those in the control group after intervention (P<0.05). The incidence 
      of pulmonary infection in the observation group was significantly lower than that 
      in the control group. The postoperative exhaust time, postoperative defecation 
      time and postoperative hospital stay were shorter in the observation group than 
      in the control group (P<0.05). There was no significant difference in 
      hospitalization cost between the two groups (P>0.05). CONCLUSIONS: EN combined 
      with ERAS was more beneficial to the improvement of nutritional status and immune 
      function recovery of patients with EC after Ivor-Lewis operation. It also 
      shortened the length of hospital stay.
CI  - 2020 Journal of Thoracic Disease. All rights reserved.
FAU - Ding, Haibing
AU  - Ding H
AD  - Department of Thoracic Surgery, the First Affiliated Hospital of Soochow 
      University, Suzhou, China.
AD  - Department of Thoracic Surgery, Second People's Hospital of Taizhou City, 
      Taizhou, China.
FAU - Xu, Jin
AU  - Xu J
AD  - Department of Gastroenterology, Geriatric Hospital of Nanjing Medical University, 
      Nanjing, China.
FAU - You, Jijun
AU  - You J
AD  - Department of Thoracic Surgery, Second People's Hospital of Taizhou City, 
      Taizhou, China.
FAU - Qin, Haifeng
AU  - Qin H
AD  - Department of Thoracic Surgery, Second People's Hospital of Taizhou City, 
      Taizhou, China.
FAU - Ma, Haitao
AU  - Ma H
AD  - Department of Thoracic Surgery, the First Affiliated Hospital of Soochow 
      University, Suzhou, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC7797812
OTO - NOTNLM
OT  - Enteral nutrition support
OT  - Ivor-Lewis operation
OT  - enhanced recovery after surgery (ERAS)
OT  - esophageal cancer (EC)
OT  - nutritional status
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/jtd-20-3410). The authors have no 
      conflicts of interest to declare.
EDAT- 2021/01/16 06:00
MHDA- 2021/01/16 06:01
PMCR- 2020/12/01
CRDT- 2021/01/15 06:01
PHST- 2021/01/15 06:01 [entrez]
PHST- 2021/01/16 06:00 [pubmed]
PHST- 2021/01/16 06:01 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - jtd-12-12-7337 [pii]
AID - 10.21037/jtd-20-3410 [doi]
PST - ppublish
SO  - J Thorac Dis. 2020 Dec;12(12):7337-7345. doi: 10.21037/jtd-20-3410.