PMID- 33448050
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20211014
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 33
IP  - 7
DP  - 2021 Feb
TI  - Supramolecular Assembled Programmable Nanomedicine As In Situ Cancer Vaccine for 
      Cancer Immunotherapy.
PG  - e2007293
LID - 10.1002/adma.202007293 [doi]
AB  - Using nanotechnology for improving the immunotherapy efficiency represents a 
      major research interest in recent years. However, there are paradoxes and 
      obstacles in using a single nanoparticle to fulfill all the requirements in the 
      complicated immune activation processes. Herein, a supramolecular assembled 
      programmable immune activation nanomedicine (PIAN) for sequentially finishing 
      multiple steps after intravenous injection and eliciting robust antitumor 
      immunity in situ is reported. The programmable nanomedicine is constructed by 
      supramolecular assembly via host-guest interactions between 
      poly-[(N-2-hydroxyethyl)-aspartamide]-Pt(IV)/beta-cyclodextrin (PPCD), 
      CpG/polyamidoamine-thioketal-adamantane (CpG/PAMAM-TK-Ad), and methoxy 
      poly(ethylene glycol)-thioketal-adamantane (mPEG-TK-Ad). After intravenous 
      injection and accumulation at the tumor site, the high level of reactive oxygen 
      species in the tumor microenvironment promotes PIAN dissociation and the release 
      of PPCD (mediating tumor cell killing and antigen release) and CpG/PAMAM 
      (mediating antigen capturing and transferring to the tumor-draining lymph nodes). 
      This results in antigen-presenting cell activation, antigen presentation, and 
      robust antitumor immune responses. In combination with anti-PD-L1 antibody, the 
      PIAN cures 40% of mice in a colorectal cancer model. This PIAN provides a new 
      framework for designing programmable nanomedicine as in situ cancer vaccine for 
      cancer immunotherapy.
CI  - (c) 2021 Wiley-VCH GmbH.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
FAU - Ma, Sheng
AU  - Ma S
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
FAU - Liu, Xinming
AU  - Liu X
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
FAU - Xu, Yudi
AU  - Xu Y
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
AD  - University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 100049, 
      China.
FAU - Zhao, Jiayu
AU  - Zhao J
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, 230026, China.
FAU - Si, Xinghui
AU  - Si X
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, 230026, China.
FAU - Li, Hongxiang
AU  - Li H
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, 230026, China.
FAU - Huang, Zichao
AU  - Huang Z
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, 230026, China.
FAU - Wang, Zhenxin
AU  - Wang Z
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, 230026, China.
FAU - Tang, Zhaohui
AU  - Tang Z
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, 230026, China.
FAU - Song, Wantong
AU  - Song W
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
FAU - Chen, Xuesi
AU  - Chen X
AUID- ORCID: 0000-0003-3542-9256
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, 5625 Renmin Road, Changchun, 130022, China.
AD  - Jilin Biomedical Polymers Engineering Laboratory, Changchun Institute of Applied 
      Chemistry, 5625 Renmin Road, Changchun, 130022, China.
AD  - School of Applied Chemistry and Engineering, University of Science and Technology 
      of China, 96 Jinzhai Road, Hefei, 230026, China.
LA  - eng
GR  - 51973215/National Natural Science Foundation of China/
GR  - 51673185/National Natural Science Foundation of China/
GR  - 52003268/National Natural Science Foundation of China/
GR  - 51829302/National Natural Science Foundation of China/
GR  - 51833010/National Natural Science Foundation of China/
GR  - 52025035/National Natural Science Foundation of China/
GR  - 51520105004/National Natural Science Foundation of China/
GR  - 20190103112JH/Program of Scientific Development of Jilin Province Science/
GR  - Youth Innovation Promotion Association of the Chinese Academy of Sciences/
PT  - Journal Article
DEP - 20210114
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 0 (Antibodies, Monoclonal, Humanized)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cancer Vaccines)
RN  - 0 (Dendrimers)
RN  - 0 (Interleukin-6)
RN  - 0 (PAMAM Starburst)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (beta-Cyclodextrins)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
RN  - 52CMI0WC3Y (atezolizumab)
RN  - JV039JZZ3A (betadex)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal, Humanized/*pharmacology
MH  - Antigen-Presenting Cells
MH  - Antineoplastic Agents/*chemistry/pharmacology
MH  - Antineoplastic Combined Chemotherapy Protocols/*pharmacology
MH  - Cancer Vaccines/*chemistry/pharmacology
MH  - Cell Line, Tumor
MH  - Colorectal Neoplasms/*immunology
MH  - Dendrimers/*chemistry
MH  - Humans
MH  - Immunotherapy
MH  - Interleukin-6/metabolism
MH  - Mice
MH  - Neoplasms, Experimental
MH  - Polyethylene Glycols/chemistry
MH  - Tumor Microenvironment
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - beta-Cyclodextrins/pharmacology
OTO - NOTNLM
OT  - cancer vaccines
OT  - immunotherapy
OT  - nanomedicine
OT  - programmable nanomedicine
OT  - supramolecular assembly
EDAT- 2021/01/16 06:00
MHDA- 2021/10/15 06:00
CRDT- 2021/01/15 06:04
PHST- 2020/10/25 00:00 [received]
PHST- 2020/11/20 00:00 [revised]
PHST- 2021/01/16 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
PHST- 2021/01/15 06:04 [entrez]
AID - 10.1002/adma.202007293 [doi]
PST - ppublish
SO  - Adv Mater. 2021 Feb;33(7):e2007293. doi: 10.1002/adma.202007293. Epub 2021 Jan 
      14.