PMID- 33448675
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 24
IP  - 3
DP  - 2021 Mar
TI  - HLA-B*27:04 associated with enthesitis and younger age of onset, and HLA-B allele 
      profile in patients with ankylosing spondylitis in Thailand: A cross-sectional 
      study.
PG  - 411-417
LID - 10.1111/1756-185X.14055 [doi]
AB  - AIM: The aims of this study were to estimate human leukocyte antigen (HLA)-B 
      allele frequency, to identify alleles associated with ankylosing spondylitis 
      (AS), and to explore manifestations in various HLA-B*27 in Thai AS patients. 
      METHODS: This was a cross-sectional study. Thai patients older than 18 years with 
      diagnosed AS according to modified New York criteria who visited Siriraj Hospital 
      (Bangkok, Thailand) were consecutively enrolled. HLA-B alleles were determined by 
      reverse sequence-specific oligonucleotide assays, and were assigned at a 4-digit 
      resolution. HLA-B alleles of 334 unrelated healthy Thai donors who participated 
      in a previous phase 2b dengue vaccine clinical trial were included as controls. 
      Odds ratio (OR) and Fisher's exact test were used to estimate association between 
      allele and AS. The P value significance threshold was calculated according to 
      Bonferroni. RESULTS: Among the 88 patients who were recruited, 34 HLA-B alleles 
      were identified, and all patients were heterozygous. The prevalence of HLA-B*27 
      was 89.8%, and 4 alleles of HLA-B*27 were identified. HLA-B*27:04 (OR: 39.4, 
      P < .0001) and HLA-B*27:05 (OR: 13.8, P = .0011) were associated with AS. In 
      contrast, HLA-B*27:06 was not found to be associated with AS (OR: 0.4, P = .241). 
      AS patients carrying HLA-B*27:04 were more likely to have enthesitis and younger 
      age at onset than those carrying HLA-B*27:05. CONCLUSIONS: HLA-B*27:04 and 
      HLA-B*27:05 were both found to be strongly associated with Thai AS. HLA-B*27:06 
      showed a neutral allele for Thai AS. AS patients with HLA-B*27:04 had more 
      enthesitis and younger age at onset than those with HLA-B*27:05.
CI  - (c) 2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Chiowchanwisawakit, Praveena
AU  - Chiowchanwisawakit P
AUID- ORCID: 0000-0002-4253-9229
AD  - Division of Rheumatology, Department of Medicine, Faculty of Medicine, Siriraj 
      Hospital, Mahidol University, Bangkok, Thailand.
FAU - Pithukpakorn, Manop
AU  - Pithukpakorn M
AUID- ORCID: 0000-0003-3611-5718
AD  - Division of Medical Genetics, Department of Medicine, Faculty of Medicine, 
      Siriraj Hospital, Mahidol University, Bangkok, Thailand.
FAU - Luangtrakool, Komon
AU  - Luangtrakool K
AD  - Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
FAU - Permpikul, Parichart
AU  - Permpikul P
AD  - Department of Transfusion Medicine, Faculty of Medicine Siriraj Hospital, Mahidol 
      University, Bangkok, Thailand.
LA  - eng
GR  - WI 227851/Pfizer (Thailand), Ltd. (investigator-initiated research)/
GR  - R016136002/the Siriraj Research Fund, Faculty of Medicine Siriraj Hospital, 
      Mahidol University/
PT  - Journal Article
PT  - Multicenter Study
DEP - 20210115
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-B27 Antigen)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - Cross-Sectional Studies
MH  - DNA/*genetics
MH  - Enthesopathy/epidemiology/*etiology/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotyping Techniques
MH  - HLA-B27 Antigen/*genetics/metabolism
MH  - Humans
MH  - Incidence
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Spondylitis, Ankylosing/complications/epidemiology/*genetics
MH  - Thailand/epidemiology
OTO - NOTNLM
OT  - HLA-B*27:04
OT  - HLA-B subtype
OT  - HLA-B27
OT  - Thai
OT  - ankylosing spondylitis
EDAT- 2021/01/16 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/01/15 08:48
PHST- 2020/09/28 00:00 [received]
PHST- 2020/11/19 00:00 [revised]
PHST- 2020/12/17 00:00 [accepted]
PHST- 2021/01/16 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/01/15 08:48 [entrez]
AID - 10.1111/1756-185X.14055 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2021 Mar;24(3):411-417. doi: 10.1111/1756-185X.14055. Epub 2021 
      Jan 15.