PMID- 33452428
OWN - NLM
STAT- MEDLINE
DCOM- 20210914
LR  - 20210914
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 15
TI  - Changes in acoustic cardiographic parameters before and after hemodialysis are 
      associated with overall and cardiovascular mortality in hemodialysis patients.
PG  - 1559
LID - 10.1038/s41598-021-81286-5 [doi]
LID - 1559
AB  - Acoustic cardiography can provide simultaneous electrocardiography and acoustic 
      cardiac data to assess the electronic and mechanical heart functions. The aim of 
      this study was to assess whether changes in acoustic cardiographic parameters 
      (ACPs) before and after hemodialysis (HD) are associated with overall and 
      cardiovascular (CV) mortality in HD patients. A total of 162 HD patients was 
      enrolled and ACPs were measured before and after HD, including left ventricular 
      systolic time (LVST), systolic dysfunction index (SDI), third (S3) and fourth 
      (S4) heart sounds, and electromechanical activation time (EMAT). During a 
      follow-up of 2.9 years, 25 deaths occurred with 16 from CV causes. Multivariate 
      analysis showed that high  big up tri, openSDI (per 1; hazard ratio [HR], 2.178; 95% confidence 
      interval [CI], 1.189-3.990), high  big up tri, openEMAT (per 1%; HR, 2.218; 95% CI 1.382-3.559), 
      and low  big up tri, openLVST (per 1 ms; HR, 0.947; 95% CI 0.912-0.984) were independently 
      associated with increased overall mortality. In addition, high  big up tri, openEMAT (per 1%; HR, 
      2.141; 95% CI 1.117-4.102), and low  big up tri, openLVST (per 1 ms; HR, 0.777; 95% CI 
      0.637-0.949) were associated with increased CV mortality. In conclusion, the 
      changes in ACPs before and after HD may be a useful clinical marker and stronger 
      prognostic marker of overall and CV mortality than ACPs before HD.
FAU - Chung, Tung-Ling
AU  - Chung TL
AD  - Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan, ROC.
AD  - Division of Nephrology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 
      ROC.
FAU - Liu, Yi-Hsueh
AU  - Liu YH
AD  - Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan, ROC.
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan, ROC.
AD  - Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
FAU - Huang, Jiun-Chi
AU  - Huang JC
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan, ROC.
AD  - Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
AD  - Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan, ROC.
FAU - Wu, Pei-Yu
AU  - Wu PY
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan, ROC.
AD  - Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
FAU - Chen, Szu-Chia
AU  - Chen SC
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan, ROC. scarchenone@yahoo.com.tw.
AD  - Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC. 
      scarchenone@yahoo.com.tw.
AD  - Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan, ROC. scarchenone@yahoo.com.tw.
FAU - Chang, Jer-Ming
AU  - Chang JM
AD  - Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.
AD  - Faculty of Medicine, College of Medicine, Kaohsiung Medical University, 
      Kaohsiung, Taiwan, ROC.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210115
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
SB  - IM
MH  - Acoustics
MH  - Aged
MH  - Biomarkers
MH  - Electrocardiography/*methods
MH  - Female
MH  - Heart Failure/physiopathology
MH  - Heart Sounds/*physiology
MH  - Heart Ventricles/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Renal Dialysis/*mortality
MH  - Stroke Volume/physiology
PMC - PMC7810842
COIS- The authors declare no competing interests.
EDAT- 2021/01/17 06:00
MHDA- 2021/09/15 06:00
PMCR- 2021/01/15
CRDT- 2021/01/16 05:37
PHST- 2020/11/26 00:00 [received]
PHST- 2021/01/05 00:00 [accepted]
PHST- 2021/01/16 05:37 [entrez]
PHST- 2021/01/17 06:00 [pubmed]
PHST- 2021/09/15 06:00 [medline]
PHST- 2021/01/15 00:00 [pmc-release]
AID - 10.1038/s41598-021-81286-5 [pii]
AID - 81286 [pii]
AID - 10.1038/s41598-021-81286-5 [doi]
PST - epublish
SO  - Sci Rep. 2021 Jan 15;11(1):1559. doi: 10.1038/s41598-021-81286-5.