PMID- 33452567
OWN - NLM
STAT- MEDLINE
DCOM- 20210722
LR  - 20210722
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 36
IP  - 6
DP  - 2021 Aug
TI  - Involvement of substance P, osteopontin and satellite glial cells on 
      photobiomodulation-induced antinociceptive effect in an experimental model of 
      dentin hypersensitivity.
PG  - 1297-1305
LID - 10.1007/s10103-021-03246-9 [doi]
AB  - The aim of this work was to investigate the involvement of substance P (SP), 
      osteopontin (OPN), and satellite glial cells (SGC) on photobiomodulation-induced 
      (PBM) antinociceptive effect in an experimental model of dentin hypersensitivity 
      (DH). Rats ingested isotonic drink (ID, pH 2.87) for 45 consecutive days and 
      after this period received PBM irradiation at lambda660 nm or lambda808 nm (1 J, 3.5 
      J/cm(2), 100 mW, 10 s, 0.028 cm(2), continuous wave, 3 consecutive daily 
      sessions), and were evaluated for nociceptive behavior 24, 48, 72 h, and 14 days 
      after laser treatments. ID ingestion induced an increase on thermal sensitivity 
      of DH characteristics in rats that was completely reversed by PBM treatment at 
      both 660 and 808 nm. Immunohistochemical analysis revealed increased SP 
      expression at both dentin-pulp complex (DPC) and trigeminal ganglia (TG) of 
      DH-rats which did not occur in PBM groups by PBM treatment. Also, the increase of 
      glial fibrillary acidic protein (GFAP) observed in the TG of DH-rats was also 
      reversed by PBM treatment. Finally, PBM at both 660 and 808 nm increased OPN 
      expression in the dentin-pulp complex of DH-rats after 14 days of PBM treatment. 
      All in all, this data demonstrates that PBM reverses nociception in a DH 
      experimental model by inhibiting neurogenic inflammation and inducing a 
      regenerative response.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd. 
      part of Springer Nature.
FAU - de Oliveira, Victhor Teixeira
AU  - de Oliveira VT
AD  - Department of Anatomy, Laboratory of Neuromodulation of Experimental Pain, 
      University of Sao Paulo, Av Lineu Prestes 2415, ICB III, Sao Paulo, 05508-000, 
      Brazil.
FAU - Ferrara-Jr, Joao Ignacio
AU  - Ferrara-Jr JI
AD  - Department of Anatomy, Laboratory of Neuromodulation of Experimental Pain, 
      University of Sao Paulo, Av Lineu Prestes 2415, ICB III, Sao Paulo, 05508-000, 
      Brazil.
FAU - Matielo, Heloisa Alonso
AU  - Matielo HA
AD  - Department of Anatomy, Laboratory of Neuromodulation of Experimental Pain, 
      University of Sao Paulo, Av Lineu Prestes 2415, ICB III, Sao Paulo, 05508-000, 
      Brazil.
FAU - da Silva Alves, Adilson
AU  - da Silva Alves A
AD  - Department of Physiology, Laboratory of Cellular Neurobiology, University of Sao 
      Paulo, Av Lineu Prestes 1524, ICB I, Sao Paulo, 05508-000, Brazil.
FAU - Britto, Luiz Roberto
AU  - Britto LR
AD  - Department of Physiology, Laboratory of Cellular Neurobiology, University of Sao 
      Paulo, Av Lineu Prestes 1524, ICB I, Sao Paulo, 05508-000, Brazil.
FAU - Aranha, Ana Cecilia Correa
AU  - Aranha ACC
AD  - Department of Restorative Dentistry, School of Dentistry, Special Laboratory of 
      Lasers in Dentistry (LELO), University of Sao Paulo, Av. Prof. Lineu Prestes 
      2227, Sao Paulo, SP, 05508-000, Brazil.
FAU - Dale, Camila Squarzoni
AU  - Dale CS
AUID- ORCID: 0000-0002-3421-7799
AD  - Department of Anatomy, Laboratory of Neuromodulation of Experimental Pain, 
      University of Sao Paulo, Av Lineu Prestes 2415, ICB III, Sao Paulo, 05508-000, 
      Brazil. camila.dale@usp.br.
LA  - eng
PT  - Journal Article
DEP - 20210115
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
RN  - 0 (Analgesics)
RN  - 106441-73-0 (Osteopontin)
RN  - 33507-63-0 (Substance P)
SB  - IM
MH  - Analgesics
MH  - Animals
MH  - Dentin Sensitivity
MH  - Low-Level Light Therapy
MH  - Male
MH  - Models, Theoretical
MH  - Neuroglia
MH  - Nociception
MH  - Osteopontin
MH  - Rats
MH  - *Substance P
MH  - Trigeminal Ganglion
OTO - NOTNLM
OT  - Dentin hypersensitivity
OT  - Osteopontin
OT  - Photobiomodulation
OT  - Satellite glial cells
OT  - Substance P
EDAT- 2021/01/17 06:00
MHDA- 2021/07/23 06:00
CRDT- 2021/01/16 05:40
PHST- 2020/10/14 00:00 [received]
PHST- 2021/01/04 00:00 [accepted]
PHST- 2021/01/17 06:00 [pubmed]
PHST- 2021/07/23 06:00 [medline]
PHST- 2021/01/16 05:40 [entrez]
AID - 10.1007/s10103-021-03246-9 [pii]
AID - 10.1007/s10103-021-03246-9 [doi]
PST - ppublish
SO  - Lasers Med Sci. 2021 Aug;36(6):1297-1305. doi: 10.1007/s10103-021-03246-9. Epub 
      2021 Jan 15.