PMID- 33453078
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1868-6982 (Electronic)
IS  - 1868-6974 (Linking)
VI  - 28
IP  - 5
DP  - 2021 May
TI  - Secure intravariceal sclerotherapy with red dichromatic imaging decreases the 
      recurrence rate of esophageal varices: A propensity score matching analysis.
PG  - 431-442
LID - 10.1002/jhbp.894 [doi]
AB  - BACKGROUND: Red dichromatic imaging (RDI) is next-generation image-enhanced 
      endoscopy technique released in July 2020. We previously reported that RDI can 
      predict esophageal varices (EV) depth and decrease their recurrence rate by 
      accurate intravariceal injections during endoscopic injection sclerotherapy (EIS) 
      using unreleased prototype RDI endoscope. In this study, we analyzed whether RDI 
      improves the overall survival (OS) rate and whether it is more accurate 
      independent predictor of EV recurrence than white light imaging (WLI), using 
      propensity score matching. METHODS: A total of 179 patients were enrolled. 
      Patients were matched for age, platelet count, liver function, EV size, luminal 
      diameter, and EV depth using propensity score matching, and 78 patients (RDI, 39; 
      WLI, 39) were finally matched. Primary endpoints were OS and recurrence rates. 
      Secondary endpoints were success rate of intravariceal injection, operating time, 
      incidence of adverse events (AEs), and predictors associated with OS and 
      recurrence rates. RESULTS: There was no difference in OS (P = .193), but the 
      cumulative recurrence rate in the RDI group was significantly lower than in the 
      WLI group (P = .002). Success rates of intrainjection, operating time, and 
      incidence of AEs were better in the RDI group (p = 0.035, .026, and .0019, 
      respectively). Independent predictors associated with recurrence rate by Cox 
      proportional regression were RDI function and luminal diameter (P < .001 and 
      .017, respectively). CONCLUSION: RDI did not improve OS but decreased the 
      recurrence rate. Independent predictors of recurrence rate were RDI and luminal 
      diameter, resulting from secure intravariceal injections in EIS.
CI  - (c) 2021 Japanese Society of Hepato-Biliary-Pancreatic Surgery.
FAU - Furuichi, Yoshihiro
AU  - Furuichi Y
AUID- ORCID: 0000-0002-8986-9823
AD  - Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, 
      Japan.
AD  - Department of Gastroenterology, Niiza Shiki Central General Hospital, Saitama, 
      Japan.
FAU - Abe, Masakazu
AU  - Abe M
AUID- ORCID: 0000-0002-8442-3216
AD  - Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, 
      Japan.
FAU - Kasai, Yoshitaka
AU  - Kasai Y
AUID- ORCID: 0000-0003-4396-6166
AD  - Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, 
      Japan.
FAU - Takeuchi, Hirohito
AU  - Takeuchi H
AUID- ORCID: 0000-0002-2082-3202
AD  - Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, 
      Japan.
FAU - Yoshimasu, Yuu
AU  - Yoshimasu Y
AUID- ORCID: 0000-0003-0818-2294
AD  - Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, 
      Japan.
FAU - Itoi, Takao
AU  - Itoi T
AUID- ORCID: 0000-0002-9433-8437
AD  - Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, 
      Japan.
LA  - eng
GR  - Japanese Ministry of Health, Labour and Welfare/
PT  - Journal Article
DEP - 20210305
PL  - Japan
TA  - J Hepatobiliary Pancreat Sci
JT  - Journal of hepato-biliary-pancreatic sciences
JID - 101528587
SB  - IM
MH  - *Esophageal and Gastric Varices/diagnostic imaging/therapy
MH  - Gastrointestinal Hemorrhage
MH  - Humans
MH  - Propensity Score
MH  - Recurrence
MH  - Sclerotherapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - dual red imaging
OT  - endoscopic injection sclerotherapy
OT  - endoscopic ultrasound
OT  - esophageal varices
OT  - image-enhanced endoscopy
OT  - red dichromatic imaging
EDAT- 2021/01/17 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/01/16 12:07
PHST- 2020/12/01 00:00 [revised]
PHST- 2020/09/14 00:00 [received]
PHST- 2021/01/07 00:00 [accepted]
PHST- 2021/01/17 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/01/16 12:07 [entrez]
AID - 10.1002/jhbp.894 [doi]
PST - ppublish
SO  - J Hepatobiliary Pancreat Sci. 2021 May;28(5):431-442. doi: 10.1002/jhbp.894. Epub 
      2021 Mar 5.