PMID- 33453456
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20210929
IS  - 2352-5568 (Electronic)
IS  - 2352-5568 (Linking)
VI  - 40
IP  - 1
DP  - 2021 Feb
TI  - The effect of vitamin C on pulmonary oedema in patients with severe preeclampsia: 
      A single-centre, randomised, placebo-controlled, double-blind trial.
PG  - 100800
LID - S2352-5568(21)00003-5 [pii]
LID - 10.1016/j.accpm.2021.100800 [doi]
AB  - OBJECTIVE: To determine whether vitamin C in the first three days postpartum 
      reduces pulmonary oedema (PE) assessed by lung ultrasound in patients with severe 
      preeclampsia. DESIGN: Randomised, placebo-controlled, double-blind trial. 
      SETTING: Tertiary perinatal centre. POPULATION: Consecutively admitted patients 
      with singleton pregnancies complicated by severe preeclampsia. METHODS: 
      Thirty-four patients received vitamin C (1.5 g/6 h) (n = 17) or placebo (n = 17) 
      at days 1, 2, and 3 postdelivery. Mann-Whitney-U test was used to compare vitamin 
      C vs placebo groups. A p </= 0.05 was considered statistically significant. MAIN 
      OUTCOME MEASURES: Lung ultrasound was performed once daily in the first three 
      days following delivery. Echo Comet Score (ECS) on day 1 postdelivery was the 
      primary outcome studied and was obtained using the 28-rib interspaces technique. 
      ECS on days 2 and 3 postdelivery were secondary outcomes. RESULTS: There was no 
      significant difference in ECS on day 1 (median 23 (inter-quartile range (IQR) 
      21-61) vs 18 (IQR 8-35); p = 0.31). All ultrasound examinations on day 1 were 
      performed within six hours from delivery. On days 2 and 3, ECS was significantly 
      lower in vitamin C group compared to placebo (8 (IQR 3-14) vs 35 (IQR 15-78); 
      p = 0.03 and 5 (IQR 3-10) vs 18 (IQR 18-44); p = 0.04, respectively). CONCLUSION: 
      A single dose of intravenous vitamin C did not reduce PE in postpartum patients 
      with severe preeclampsia on day 1 after delivery. Repeated doses, however, seem 
      to have a delayed effect with a reduction in PE detected on ultrasound on days 2 
      and 3 following delivery. TRIAL REGISTRATION: This trial is registered at 
      ClinicalTrials.gov: ID NCT03451266 
      (https://clinicaltrials.gov/ct2/show/NCT03451266?term=NCT03451266&draw=2&rank=1).
CI  - Copyright (c) 2021 Societe francaise d'anesthesie et de reanimation (Sfar). 
      Published by Elsevier Masson SAS. All rights reserved.
FAU - Korenc, Monika
AU  - Korenc M
AD  - Department of Perinatology, Division of Obstetrics and Gynaecology, University 
      Medical Centre Ljubljana, Slovenia.
FAU - Zieleskiewicz, Laurent
AU  - Zieleskiewicz L
AD  - Department of Anaesthesiology and Critical Care Medicine, North Hospital, Aix 
      Marseille University, Marseille, France.
FAU - Stopar Pintaric, Tatjana
AU  - Stopar Pintaric T
AD  - Department of Anaesthesiology and Intensive Therapy, University Medical Centre 
      Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Slovenia.
FAU - Blajic, Iva
AU  - Blajic I
AD  - Department of Anaesthesiology and Intensive Therapy, University Medical Centre 
      Ljubljana, Slovenia.
FAU - Ambrozic, Jana
AU  - Ambrozic J
AD  - Department of Cardiology, University Medical Centre Ljubljana, Slovenia.
FAU - Lucovnik, Miha
AU  - Lucovnik M
AD  - Department of Perinatology, Division of Obstetrics and Gynaecology, University 
      Medical Centre Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, 
      Slovenia. Electronic address: miha.lucovnik@kclj.si.
LA  - eng
SI  - ClinicalTrials.gov/NCT03451266
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20210114
PL  - France
TA  - Anaesth Crit Care Pain Med
JT  - Anaesthesia, critical care & pain medicine
JID - 101652401
RN  - PQ6CK8PD0R (Ascorbic Acid)
SB  - IM
CIN - Anaesth Crit Care Pain Med. 2021 Feb;40(1):100806. PMID: 33493630
CIN - Anaesth Crit Care Pain Med. 2021 Feb;40(1):100814. PMID: 33582303
MH  - Ascorbic Acid
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Lung
MH  - *Pre-Eclampsia/drug therapy
MH  - Pregnancy
MH  - *Pulmonary Edema/diagnostic imaging
OTO - NOTNLM
OT  - Ascorbic acid
OT  - Lung ultrasound
OT  - Preeclampsia
OT  - Pulmonary oedema
OT  - Vitamin C
EDAT- 2021/01/17 06:00
MHDA- 2021/09/30 06:00
CRDT- 2021/01/16 20:09
PHST- 2020/08/07 00:00 [received]
PHST- 2020/09/18 00:00 [revised]
PHST- 2020/09/22 00:00 [accepted]
PHST- 2021/01/17 06:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PHST- 2021/01/16 20:09 [entrez]
AID - S2352-5568(21)00003-5 [pii]
AID - 10.1016/j.accpm.2021.100800 [doi]
PST - ppublish
SO  - Anaesth Crit Care Pain Med. 2021 Feb;40(1):100800. doi: 
      10.1016/j.accpm.2021.100800. Epub 2021 Jan 14.