PMID- 33454206
OWN - NLM
STAT- Publisher
LR  - 20240222
IS  - 2173-5743 (Electronic)
IS  - 2173-5743 (Linking)
DP  - 2021 Jan 13
TI  - Vitamin D Levels in Patients With Small and Medium Vessel Vasculitis.
LID - S1699-258X(20)30275-8 [pii]
LID - 10.1016/j.reuma.2020.11.004 [doi]
AB  - OBJECTIVES: To determine the prevalence of vitamin D deficiency in patients with 
      small and medium vessel systemic vasculitis. METHODS: In this cross-sectional 
      study, 25-hydroxy (OH) vitamin D3 levels were measured in adult patients with 
      systemic small and medium vessel vasculitis including antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV), cryoglobulinaemic vasculitis (CryV), IgA 
      vasculitis (IgAV) and polyarteritis nodosa (PAN), and age- and sex-matched 
      healthy subjects (HS) and patients with rheumatoid arthritis (RA) as control 
      groups. 25OH vitamin D3 levels<30ng/ml and <20ng/ml were regarded as 
      insufficiency and deficiency, respectively. RESULTS: Fifty-seven patients (42 
      AAV, 2 CryV, 8 IgA vasculitis, 5 PAN) with systemic vasculitis, 101 HS, and 111 
      RA patients were included. The mean 25OH vitamin D3 level was 21.8+/-14.2ng/mL in 
      patients with vasculitis, 42.7+/-27.6ng/mL in HS (p<.001) and 20.1+/-18.47ng/mL in 
      patients with RA (p=.54). Vitamin D insufficiency and deficiency were 
      significantly higher in patients with systemic vasculitis compared to HS (75.4% 
      vs 33.7%, p<.001; %50 vs 21.8%, p<.001, respectively). Vitamin D status was not 
      different in patients with systemic vasculitis compared to RA. There was a 
      negative correlation between vitamin D status and CRP levels (=-.364, p=.007). 
      The multivariate logistic regression analysis showed that renal involvement was 
      significantly associated with vitamin D deficiency/insufficiency in patients with 
      vasculitis (OR 22.5 [95% CI 1.6-128.9]. CONCLUSION: Vitamin D deficiency and 
      insufficiency are more frequent in patients with systemic small and medium vessel 
      vasculitis and RA than HS. Renal involvement is one of the factors associated 
      with vitamin D deficiency/insufficiency in patients with vasculitis.
CI  - Copyright (c) 2020 Elsevier Espana, S.L.U. and Sociedad Espanola de Reumatologia y 
      Colegio Mexicano de Reumatologia. All rights reserved.
FAU - Korkmaz, Fatma Nur
AU  - Korkmaz FN
AD  - Ankara University, School of Medicine, Department of Internal Medicine, Division 
      of Endocrinology, Ankara, Turkey. Electronic address: f.nur_3717@hotmail.com.
FAU - Ozen, Gulsen
AU  - Ozen G
AD  - University of Nebraska Medical Center, Department of Internal Medicine, Omaha, 
      NE, USA.
FAU - Unal, Ali Ugur
AU  - Unal AU
AD  - Marmara University, School of Medicine, Department of Internal Medicine, Division 
      of Rheumatology, Istanbul, Turkey.
FAU - Odabasi, Asli
AU  - Odabasi A
AD  - Marmara University, School of Medicine, Department of Internal Medicine, 
      Istanbul, Turkey.
FAU - Can, Meryem
AU  - Can M
AD  - Medipol Mega Hospitals Complex, Department of Rheumatology, Istanbul, Turkey.
FAU - Asicioglu, Ebru
AU  - Asicioglu E
AD  - Marmara University, School of Medicine Hospital, Department of Internal Medicine, 
      Division of Nephrology, Istanbul, Turkey.
FAU - Tuglular, Serhan
AU  - Tuglular S
AD  - Marmara University, School of Medicine Hospital, Department of Internal Medicine, 
      Division of Nephrology, Istanbul, Turkey.
FAU - Direskeneli, Haner
AU  - Direskeneli H
AD  - Marmara University, School of Medicine, Department of Internal Medicine, Division 
      of Rheumatology, Istanbul, Turkey.
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20210113
PL  - Spain
TA  - Reumatol Clin (Engl Ed)
JT  - Reumatologia clinica
JID - 101717526
SB  - IM
OTO - NOTNLM
OT  - Artritis reumatoide
OT  - Deficiencia
OT  - Deficiency
OT  - Rheumatoid arthritis
OT  - Vasculitis
OT  - Vitamin D
OT  - Vitamina D
EDAT- 2021/01/18 06:00
MHDA- 2021/01/18 06:00
CRDT- 2021/01/17 20:24
PHST- 2020/06/27 00:00 [received]
PHST- 2020/11/11 00:00 [revised]
PHST- 2020/11/12 00:00 [accepted]
PHST- 2021/01/17 20:24 [entrez]
PHST- 2021/01/18 06:00 [pubmed]
PHST- 2021/01/18 06:00 [medline]
AID - S1699-258X(20)30275-8 [pii]
AID - 10.1016/j.reuma.2020.11.004 [doi]
PST - aheadofprint
SO  - Reumatol Clin (Engl Ed). 2021 Jan 13:S1699-258X(20)30275-8. doi: 
      10.1016/j.reuma.2020.11.004.