PMID- 33454992
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1503
IP  - 1
DP  - 2021 Nov
TI  - Resveratrol prevents steroid-induced osteonecrosis of the femoral head via 
      miR-146a modulation.
PG  - 23-37
LID - 10.1111/nyas.14555 [doi]
AB  - The purpose of this study was to investigate the possible use of resveratrol 
      (Res) to reverse abnormal osteogenesis/osteoclastogenesis activity that occurs 
      during femoral head osteonecrosis and to explore the detailed mechanisms. 
      Application of Res to bone marrow-derived mesenchymal stem cells in vitro 
      promoted survival, inhibited apoptosis, and downregulated expression of reactive 
      oxygen species expression. Moreover, Res application was associated with elevated 
      microRNA-146a (miR-146a) expression, osteogenic differentiation, and suppressed 
      osteoclastic differentiation, which were markedly reversed by miR-146a inhibitor. 
      Histopathological observations and micro-computed tomography scanning results 
      indicated that the Res-treated group had lower incidence of osteonecrosis and 
      better bone microstructure than the untreated group. Res inhibited 
      osteoclastogenesis through altering the levels of sirtuin1 (Sirt1), nuclear 
      transcription factor-kappaB (NF-kappaB), and receptor activator of NF-kappaB ligand (RANKL). 
      Simultaneously, Res treatment improved bone formation and increased beta-catenin and 
      runt-related transcription factor 2 (Runt2) expression levels, while reducing 
      forkhead box class O (FOXO) family protein levels. The results of our study 
      suggest that Res prevents steroid-induced osteonecrosis by upregulating miR-146a, 
      and thereby stabilizes osteogenesis/osteoclastogenesis homeostasis via Wnt/FOXO 
      and Sirt1/NF-kappaB pathways.
CI  - (c) 2021 New York Academy of Sciences.
FAU - Nan, Kai
AU  - Nan K
AD  - Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi, People's Republic of China.
FAU - Pei, Jun-Peng
AU  - Pei JP
AD  - Department of Orthopaedics, Wuhan General Hospital of Guangzhou Command, Wuhan, 
      People's Republic of China.
FAU - Fan, Li-Hong
AU  - Fan LH
AUID- ORCID: 0000-0002-8864-6732
AD  - Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi, People's Republic of China.
FAU - Zhang, Yuan-Kai
AU  - Zhang YK
AD  - Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi, People's Republic of China.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi, People's Republic of China.
FAU - Liu, Kang
AU  - Liu K
AD  - Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, People's Republic of China.
FAU - Shi, Zhi-Bin
AU  - Shi ZB
AD  - Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi, People's Republic of China.
FAU - Dang, Xiao-Qian
AU  - Dang XQ
AD  - Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi, People's Republic of China.
FAU - Wang, Kun-Zheng
AU  - Wang KZ
AD  - Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong 
      University, Shaanxi, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210117
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
RN  - 0 (Protective Agents)
RN  - 0 (Steroids)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Biomarkers
MH  - Disease Management
MH  - Disease Susceptibility
MH  - Femur Head Necrosis/diagnostic imaging/*etiology/*pathology/prevention & control
MH  - Gene Expression Regulation/*drug effects
MH  - MicroRNAs/*genetics
MH  - Protective Agents/*pharmacology
MH  - Resveratrol/*pharmacology
MH  - Steroids/*adverse effects
OTO - NOTNLM
OT  - FOXO
OT  - NF-kappaB
OT  - Sirt1
OT  - Wnt
OT  - femoral head
OT  - miR-146a
OT  - resveratrol
OT  - steroid-induced osteonecrosis
EDAT- 2021/01/18 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/01/17 20:36
PHST- 2020/11/13 00:00 [revised]
PHST- 2020/07/16 00:00 [received]
PHST- 2020/12/08 00:00 [accepted]
PHST- 2021/01/18 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/01/17 20:36 [entrez]
AID - 10.1111/nyas.14555 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2021 Nov;1503(1):23-37. doi: 10.1111/nyas.14555. Epub 2021 Jan 
      17.