PMID- 33455465
OWN - NLM
STAT- MEDLINE
DCOM- 20210903
LR  - 20210903
IS  - 1464-5033 (Electronic)
IS  - 0301-4460 (Linking)
VI  - 48
IP  - 1
DP  - 2021 Feb
TI  - Effect of MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphisms and obesity 
      in T2DM: a study among Bengalee Hindu caste population of West Bengal, India.
PG  - 62-65
LID - 10.1080/03014460.2021.1876920 [doi]
AB  - Type 2 diabetes mellitus (T2DM) susceptibility has increased due to the 
      independent risks of genetic polymorphism and obesity as well as combinations of 
      these. Despite recent advancements in T2DM management and diagnosis, the 
      challenges of susceptibility and prognosis still remain. The present work is 
      attempted to understand the association of methylenetetrahydrofolate reductase 
      (MTHFR) (rs1801133) and FTO (rs9939609) genetic polymorphisms and obesity with 
      T2DM among the Bengalee Hindu caste population of West Bengal, India. One hundred 
      and four clinically diagnosed T2DM male patients and 176 healthy males, without 
      family history of T2DM, (control group) of the endogamous linguistic group 
      (Bengalee Hindu caste) participated. Genotyping was performed using the PCR-RFLP 
      method following the isolation of genomic DNA. MTHFR (rs1801133) genetic 
      polymorphism with CT genotype revealed significantly higher risk (OR = 3.44; p 
      = .01) of T2DM compared to the CC genotype. The attenuation of MTHFR-T2DM risk 
      after adjustment for age and waist circumference revealed obesity and age effects 
      in progression of T2DM. T2DM patients also had significantly (p < .05) higher 
      overall obesity, central obesity, and SBP compared to the controls. However, FTO 
      (rs9939609) genetic polymorphism demonstrated no significant (p= .854) effect on 
      T2DM and obesity. The present study identified that MTHFR genetic polymorphism 
      and obesity might be used as screening tools for early prognosis of T2DM.
FAU - Sarkar, Pranabesh
AU  - Sarkar P
AUID- ORCID: 0000-0003-3788-6514
AD  - Department of Anthropology, University of Calcutta, Kolkata, India.
FAU - Chatterjee, Diptendu
AU  - Chatterjee D
AD  - Department of Anthropology, University of Calcutta, Kolkata, India.
FAU - Bandyopadhyay, Arup Ratan
AU  - Bandyopadhyay AR
AUID- ORCID: 0000-0003-3119-0022
AD  - Department of Anthropology, University of Calcutta, Kolkata, India.
LA  - eng
PT  - Journal Article
DEP - 20210128
PL  - England
TA  - Ann Hum Biol
JT  - Annals of human biology
JID - 0404024
RN  - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO)
RN  - EC 1.14.11.33 (FTO protein, human)
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alpha-Ketoglutarate-Dependent Dioxygenase FTO/*genetics/metabolism
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Humans
MH  - India
MH  - Male
MH  - Methylenetetrahydrofolate Reductase (NADPH2)/*genetics/metabolism
MH  - Middle Aged
MH  - Obesity/*genetics
MH  - *Polymorphism, Genetic
MH  - Young Adult
OTO - NOTNLM
OT  - Bengalee Hindu caste
OT  - PCR-RFLP
OT  - T2DM
OT  - genetic polymorphism
OT  - obesity
EDAT- 2021/01/19 06:00
MHDA- 2021/09/04 06:00
CRDT- 2021/01/18 05:21
PHST- 2021/01/19 06:00 [pubmed]
PHST- 2021/09/04 06:00 [medline]
PHST- 2021/01/18 05:21 [entrez]
AID - 10.1080/03014460.2021.1876920 [doi]
PST - ppublish
SO  - Ann Hum Biol. 2021 Feb;48(1):62-65. doi: 10.1080/03014460.2021.1876920. Epub 2021 
      Jan 28.