PMID- 3345559
OWN - NLM
STAT- MEDLINE
DCOM- 19880414
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 52
IP  - 1
DP  - 1988 Jan 15
TI  - Molecular genetics of the single-minded locus: a gene involved in the development 
      of the Drosophila nervous system.
PG  - 133-41
AB  - The embryonic neuroepithelium of Drosophila gives rise to the central nervous 
      system. We have studied the mutant phenotype and expression of a gene, 
      single-minded (sim), which is involved in generating a specific region of this 
      neuroepithelium. In sim mutant embryos, a subset of neuronal and nonneuronal 
      precursor cells lying along the midline fail to emerge with the rest of the 
      neuroepithelium. We have identified the sim transcription unit and have shown by 
      in situ hybridization to embryos that the sim gene is expressed specifically in 
      the midline neuroepithelium. Both the mutant phenotype and the temporal and 
      spatial expression of transcripts suggest that the sim gene plays a key role in 
      the emergence of this subset of cells along the midline of the developing central 
      nervous system.
FAU - Thomas, J B
AU  - Thomas JB
AD  - Department of Biological Sciences, Stanford University, California 94305.
FAU - Crews, S T
AU  - Crews ST
FAU - Goodman, C S
AU  - Goodman CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - DNA/genetics
MH  - Drosophila/embryology/*genetics
MH  - *Genes
MH  - Mutation
MH  - Nervous System/embryology
MH  - Nucleic Acid Hybridization
MH  - Phenotype
MH  - Transcription, Genetic
EDAT- 1988/01/15 00:00
MHDA- 1988/01/15 00:01
CRDT- 1988/01/15 00:00
PHST- 1988/01/15 00:00 [pubmed]
PHST- 1988/01/15 00:01 [medline]
PHST- 1988/01/15 00:00 [entrez]
AID - 0092-8674(88)90537-5 [pii]
AID - 10.1016/0092-8674(88)90537-5 [doi]
PST - ppublish
SO  - Cell. 1988 Jan 15;52(1):133-41. doi: 10.1016/0092-8674(88)90537-5.