PMID- 33455601
OWN - NLM
STAT- MEDLINE
DCOM- 20211028
LR  - 20231111
IS  - 1469-8714 (Electronic)
IS  - 0952-5238 (Print)
IS  - 0952-5238 (Linking)
VI  - 38
DP  - 2021 Jan 18
TI  - The neuroscience of diabetic retinopathy.
PG  - E001
LID - 10.1017/S0952523820000115 [doi]
AB  - Diabetic retinopathy remains a leading cause of blindness despite recent advance 
      in therapies. Traditionally, this complication of diabetes was viewed 
      predominantly as a microvascular disease but research has pointed to alterations 
      in ganglion cells, glia, microglia, and photoreceptors as well, often occurring 
      without obvious vascular damage. In neural tissue, the microvasculature and 
      neural tissue form an intimate relationship with the neural tissue providing 
      signaling cues for the vessels to form a distinct barrier that helps to maintain 
      the proper neuronal environment for synaptic signaling. This relationship has 
      been termed the neurovascular unit (NVU). Research is now focused on 
      understanding the cellular and molecular basis of the neurovascular unit and how 
      diabetes alters the normal cellular communications and disrupts the cellular 
      environment contributing to loss of vision in diabetes.
FAU - Antonetti, David A
AU  - Antonetti DA
AUID- ORCID: 0000-0003-1130-6577
AD  - Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University 
      of Michigan, Ann Arbor, Michigan.
AD  - Department of Molecular and Integrative Physiology, University of Michigan, Ann 
      Arbor, Michigan.
LA  - eng
GR  - P30 DK020572/DK/NIDDK NIH HHS/United States
GR  - R01 EY012021/EY/NEI NIH HHS/United States
GR  - R01 EY029349/EY/NEI NIH HHS/United States
GR  - R01 HL055374/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210118
PL  - England
TA  - Vis Neurosci
JT  - Visual neuroscience
JID - 8809466
SB  - IM
MH  - *Diabetes Mellitus
MH  - *Diabetic Retinopathy
MH  - Humans
MH  - Neurons
MH  - Signal Transduction
PMC - PMC8118389
MID - NIHMS1655596
OTO - NOTNLM
OT  - Blood-Retinal Barrier
OT  - Diabetes
OT  - Neurovascular Unit
OT  - Retina
COIS- Conflict of Interest The author has no conflict of interest to report.
EDAT- 2021/01/19 06:00
MHDA- 2021/10/29 06:00
PMCR- 2022/01/18
CRDT- 2021/01/18 05:22
PHST- 2021/01/18 05:22 [entrez]
PHST- 2021/01/19 06:00 [pubmed]
PHST- 2021/10/29 06:00 [medline]
PHST- 2022/01/18 00:00 [pmc-release]
AID - S0952523820000115 [pii]
AID - 10.1017/S0952523820000115 [doi]
PST - epublish
SO  - Vis Neurosci. 2021 Jan 18;38:E001. doi: 10.1017/S0952523820000115.