PMID- 33456232
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 0973-029X (Print)
IS  - 1998-393X (Electronic)
IS  - 0973-029X (Linking)
VI  - 24
IP  - 2
DP  - 2020 May-Aug
TI  - Assessment of serum and salivary adiponectin levels in newly diagnosed Type II 
      diabetes mellitus patients.
PG  - 245-250
LID - 10.4103/jomfp.JOMFP_87_18 [doi]
AB  - BACKGROUND: Adiponectin, an adipocytokine, plays an important role in the 
      development of Type 2 Diabetes Mellitus (T2DM) in obese and cardiovascular 
      disease patients, with few studies having observed low plasma concentrations. 
      Persistent low-grade inflammation, an important feature in T2DM and obesity, 
      bears an indirect influence on insulin resistance and insulin secretion and is 
      reflected by increased plasma levels of C-reactive protein (CRP). Thus, low 
      levels of anti-inflammatory cytokine, adiponectin, depicts that inflammation 
      could be the link between T2DM, obesity and adiponectin. Since these factors need 
      to be explored to prevent or adequately treat T2DM, especially among Indian 
      diabetics, this study was undertaken. Also of interest was to assess its salivary 
      concentrations. AIM: This study aimed to assess serum and salivary adiponectin 
      levels in newly diagnosed T2DM individuals along with postprandial blood sugar 
      (PPBS) and glycosylated hemoglobin (HbA(1C)) and high-sensitivity-CRP (hs-CRP). 
      MATERIALS AND METHODS: Serum and salivary levels of adiponectin, PPBS, HbA(1c) 
      and hs-CRP were assessed in 30 newly diagnosed T2DM (Group I) individuals and 
      compared with 30 healthy individuals (Group II, healthy control). Glucose oxidase 
      peroxidase, automatic analyzer, turbidimetric immunoassay and ELISA methods were 
      adopted for PPBS, HbA(1c), hs-CRP and adiponectin estimation. RESULTS: 
      Statistically significant decrease in mean serum (16.93 +/- 3.86) and salivary 
      (24.96 +/- 8.21) adiponectin levels, were observed in Group I compared to Group II 
      individuals with a p value of 0.00 and 0.04 respectively. In Group I individuals 
      a significant p value of 0.02 was noted only between salivary adiponectin and 
      PPBS. None of the other parameters correlated significantly with serum 
      adiponectin levels. CONCLUSION: Decreased serum and salivary adiponectin levels 
      in T2DM furthered the importance of its role in Indian T2DM. Decreased salivary 
      adiponectin levels probably reflected salivary hypofunction. This being the 
      preliminary study in saliva, more studies are required to emphasize its role both 
      as a diagnostic marker and as an anti-inflammatory cytokine in T2DM.
CI  - Copyright: (c) 2020 Journal of Oral and Maxillofacial Pathology.
FAU - Kalyani, R Suma
AU  - Kalyani RS
AD  - Department of Oral Pathology, Narayana Dental College and Hospital, Nellore, 
      Andhra Pradesh, India.
FAU - Raghunath, Vandana
AU  - Raghunath V
AD  - Department of Oral Pathology, Narayana Dental College and Hospital, Nellore, 
      Andhra Pradesh, India.
LA  - eng
PT  - Journal Article
DEP - 20200909
PL  - India
TA  - J Oral Maxillofac Pathol
JT  - Journal of oral and maxillofacial pathology : JOMFP
JID - 101227995
PMC - PMC7802862
OTO - NOTNLM
OT  - Adiponectin
OT  - saliva
OT  - serum
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2021/01/19 06:00
MHDA- 2021/01/19 06:01
PMCR- 2020/05/01
CRDT- 2021/01/18 05:28
PHST- 2018/04/16 00:00 [received]
PHST- 2019/05/13 00:00 [accepted]
PHST- 2021/01/18 05:28 [entrez]
PHST- 2021/01/19 06:00 [pubmed]
PHST- 2021/01/19 06:01 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
AID - JOMFP-24-245 [pii]
AID - 10.4103/jomfp.JOMFP_87_18 [doi]
PST - ppublish
SO  - J Oral Maxillofac Pathol. 2020 May-Aug;24(2):245-250. doi: 
      10.4103/jomfp.JOMFP_87_18. Epub 2020 Sep 9.