PMID- 33456608
OWN - NLM
STAT- MEDLINE
DCOM- 20210128
LR  - 20210128
IS  - 1844-3117 (Electronic)
IS  - 1844-122X (Print)
IS  - 1844-122X (Linking)
VI  - 13
IP  - 4
DP  - 2020 Oct-Dec
TI  - Incides of C-Reactive Protein, Tumor Necrosis Factor-alpha, Adiponectin, Leptin and 
      Resistin in the Blood of Patients Suffering from Chronic Pancreatitis and Type 2 
      Diabetes Mellitus.
PG  - 568-571
LID - 10.25122/jml-2020-0153 [doi]
AB  - Studying the significance of the immune response to damage and adipokine levels 
      is urgent regarding the development of both chronic pancreatitis and type 2 
      diabetes mellitus. Our objective was to study the indices of tumor necrosis 
      factor-alpha (TNF-alpha), C-reactive protein (CRP), adiponectin, leptin, and resistin as 
      links for triggering the mechanisms of development and progression of the 
      low-grade chronic systemic inflammatory response in chronic pancreatitis (CP) 
      patients with type 2 diabetes mellitus (T2DM). The study groups consisted of 87 
      patients: 47 patients with isolated CP (group I), 40 with CP combined with T2DM 
      (group II), and 41 practically healthy persons. It has been established that in 
      patients with isolated CP, the TNF-alpha concentration showed a reliable 1.57-fold (p 
      <0.05) increase compared to practically healthy persons (PHP) and a 1.32-fold 
      increase in patients who also had T2DM (p<0.05). CP patients with type 2 diabetes 
      mellitus had the highest CRP indices (5.5-fold, p <0.05. TNF-alpha and C-reactive 
      protein indices were higher in patients with chronic pancreatitis and T2DM than 
      those with isolated chronic pancreatitis, characterizing the persistence of 
      chronic systemic inflammation in case of the combined clinical course of these 
      diseases.
CI  - (c)Carol Davila University Press.
FAU - Hontsariuk, Dmytro Olecsandrovich
AU  - Hontsariuk DO
AD  - Department of Internal Medicine and Infectious diseases, Bukovinian State Medical 
      University, Chernivtsi, Ukraine.
FAU - Ferfetska, Kateryna Victorivna
AU  - Ferfetska KV
AD  - Department of Internal Medicine and Infectious diseases, Bukovinian State Medical 
      University, Chernivtsi, Ukraine.
FAU - Khrystych, Tamara Mikolaivna
AU  - Khrystych TM
AD  - Department of Physical Rehabilitation and Medical and Biological Basis of 
      Physical Education, Kamianets-Podilskyi Ivan Ohiienko National University, 
      Kamianets-Podilskyi, Ukraine.
FAU - Fediv, Olexander Ivanovich
AU  - Fediv OI
AD  - Department of Internal Medicine and Infectious diseases, Bukovinian State Medical 
      University, Chernivtsi, Ukraine.
FAU - Temerivska, Tetjana Georgiivna
AU  - Temerivska TG
AD  - Department of Physical Rehabilitation, Ergotherapy and Home Care, Yuriy Fedkovych 
      Chernivtsi National University, Chernivtsi, Ukraine.
FAU - Jiguleva, Evelina Olexandriivna
AU  - Jiguleva EO
AD  - Department of Physical Rehabilitation and Medical and Biological Basis of 
      Physical Education, Kamianets-Podilskyi Ivan Ohiienko National University, 
      Kamianets-Podilskyi, Ukraine.
FAU - Honcharuk, Ludmila Mikchaliivna
AU  - Honcharuk LM
AD  - Department of Internal Medicine and Infectious diseases, Bukovinian State Medical 
      University, Chernivtsi, Ukraine.
FAU - Olinik, Oksana Yuriivna
AU  - Olinik OY
AD  - Department of Internal Medicine and Infectious diseases, Bukovinian State Medical 
      University, Chernivtsi, Ukraine.
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - J Med Life
JT  - Journal of medicine and life
JID - 101477617
RN  - 0 (Adiponectin)
RN  - 0 (Leptin)
RN  - 0 (Resistin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adult
MH  - C-Reactive Protein/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Leptin/*blood
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis, Chronic/*blood
MH  - Resistin/*blood
MH  - Tumor Necrosis Factor-alpha/*blood
PMC - PMC7803310
OTO - NOTNLM
OT  - C-reactive protein
OT  - CP - cronic pancreatitis
OT  - CRP - C-reactive protein
OT  - Chronic pancreatitis
OT  - PHP - practically healthy persons
OT  - TNF-alpha - Tumor necrotic factor - alpha
OT  - adiponectin
OT  - leptin
OT  - resistin.
OT  - tumor necrosis factor
OT  - type 2 diabetes mellitus
EDAT- 2021/01/19 06:00
MHDA- 2021/01/29 06:00
PMCR- 2020/12/01
CRDT- 2021/01/18 05:29
PHST- 2021/01/18 05:29 [entrez]
PHST- 2021/01/19 06:00 [pubmed]
PHST- 2021/01/29 06:00 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - JMedLife-13-568 [pii]
AID - 10.25122/jml-2020-0153 [doi]
PST - ppublish
SO  - J Med Life. 2020 Oct-Dec;13(4):568-571. doi: 10.25122/jml-2020-0153.