PMID- 33458745
OWN - NLM
STAT- MEDLINE
DCOM- 20210907
LR  - 20240226
IS  - 1470-8736 (Electronic)
IS  - 0143-5221 (Linking)
VI  - 135
IP  - 3
DP  - 2021 Feb 12
TI  - Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis 
      of allergic rhinitis.
PG  - 483-494
LID - 10.1042/CS20201212 [doi]
AB  - The function of high-mobility group box 1 (HMGB1) varies according to its 
      location. However, the translocation mechanism behind HMGB1 remains unclear. We 
      hypothesize that type 2 helper T cell (Th2) cytokines are involved in the 
      translocation of HMGB1 in the upper airway epithelium. We investigated the 
      mechanism behind HMGB1 translocation using Th2 cytokine stimulation and examined 
      the clinical significance of HMGB1 translocation in allergic rhinitis (AR). 
      Cytoplasmic and extracellular HMGB1 were increased in AR. Inhibiting HMGB1 
      translocation with glycyrrhizic acid (GA) decreased the level of antigen-specific 
      immunoglobulin E (IgE), the degree of Periodic Acid-Schiff (PAS), and Sirius Red 
      staining in the murine model. The in vivo reactive oxygen species (ROS) level in 
      the nasal mucosa was higher in the mice with AR than in the controls. Th2 
      cytokine-induced up-regulation of the ROS and translocation of HMGB1 by Th2 
      cytokines was dependent on the generated ROS. The ROS level also increased in the 
      murine model. We suggest that the Th2 cytokine-dual oxidase (DUOX)2-ROS-HMGB1 
      translocation axis is important in AR pathogenesis.
CI  - (c) 2021 The Author(s). Published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Min, Hyun Jin
AU  - Min HJ
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Park, Joon Soon
AU  - Park JS
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Kim, Kyung Soo
AU  - Kim KS
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Park, Seung Yong
AU  - Park SY
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University 
      College of Medicine, Seoul, Republic of Korea.
FAU - Choi, Honghwan
AU  - Choi H
AD  - Division of Chemical Engineering, Konkuk University, Seoul, Republic of Korea.
FAU - Seo, Ju Hee
AU  - Seo JH
AD  - The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kang, Miran
AU  - Kang M
AD  - The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Yoon, Joo-Heon
AU  - Yoon JH
AD  - The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kim, Chang-Hoon
AU  - Kim CH
AD  - The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Kim, Sehoon
AU  - Kim S
AD  - Center for Theragnosis, Korea Institute of Science and Technology, Seoul, 
      Republic of Korea.
AD  - KU-KIST Graduate School of Converging Science and Technology, Korea University, 
      Seoul, Republic of Korea.
FAU - Cho, Hyung-Ju
AU  - Cho HJ
AD  - The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
AD  - Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Sci (Lond)
JT  - Clinical science (London, England : 1979)
JID - 7905731
RN  - 0 (Cytokines)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Reactive Oxygen Species)
RN  - EC 1.11.1.- (Dual Oxidases)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Dual Oxidases/*metabolism
MH  - Female
MH  - HMGB1 Protein/*metabolism
MH  - Humans
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Middle Aged
MH  - Nasal Mucosa/metabolism
MH  - Reactive Oxygen Species/*metabolism
MH  - Rhinitis, Allergic/*pathology
MH  - Th2 Cells/metabolism
MH  - Mice
OTO - NOTNLM
OT  - Th2 cytokines
OT  - allergic rhinitis
OT  - high mobility group box 1
OT  - nasal epithelium
OT  - reactive oxygen species
EDAT- 2021/01/19 06:00
MHDA- 2021/09/08 06:00
CRDT- 2021/01/18 05:36
PHST- 2020/09/28 00:00 [received]
PHST- 2021/01/14 00:00 [revised]
PHST- 2021/01/18 00:00 [accepted]
PHST- 2021/01/19 06:00 [pubmed]
PHST- 2021/09/08 06:00 [medline]
PHST- 2021/01/18 05:36 [entrez]
AID - 227611 [pii]
AID - 10.1042/CS20201212 [doi]
PST - ppublish
SO  - Clin Sci (Lond). 2021 Feb 12;135(3):483-494. doi: 10.1042/CS20201212.