PMID- 33460637
OWN - NLM
STAT- MEDLINE
DCOM- 20210421
LR  - 20210421
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 195
DP  - 2021 Apr
TI  - Estimation of dietary intake and sources of organohalogenated contaminants among 
      infants: 24-h duplicate diet survey in Fukuoka, Japan.
PG  - 110745
LID - S0013-9351(21)00039-6 [pii]
LID - 10.1016/j.envres.2021.110745 [doi]
AB  - The widespread occurrence of persistent organic pollutants (POPs) in the 
      environment is a matter of concern. In this study, selected organohalogenated 
      contaminants, including dichlorodiphenyltrichloroethane and its metabolites 
      (DDTs) polychlorinated biphenyls (PCBs), chlordanes (CHLs), hexachlorobenzene 
      (HCB), polybrominated diphenyl ethers (PBDEs), hexabromocyclododecanes (HBCDs), 
      tetrabromobisphenol A (TBBPA), 2,4,6-tribromophenol (TBP), were measured in 
      complete meal sets (24-h duplicate-diet) of Japanese infants to investigate the 
      levels, profiles, and possible sources of contamination. In total, 46 whole-day 
      meals of infants (7-24-months old) were collected during 2017 from Fukuoka, 
      Japan. To the best of our knowledge, this is the first report based on the 
      duplicate-diet method for infants. The median intakes among the POP groups were 
      highest for SigmaDDTs (18 ng/day, maximum 251 ng/day), followed by SigmaPCBs (17 ng/day, 
      maximum 198 ng/day), SigmaCHLs (14 ng/day, maximum 105 ng/day), HCB (11 ng/day, 
      maximum 64 ng/day), TBP (3.5 ng/day, maximum 109 ng/day), SigmaHBCDs (1.9 ng/day, 
      maximum 70 ng/day), TBBPA (0.72 ng/day, maximum 34 ng/day), and SigmaPBDEs 
      (0.11 ng/day, maximum 4.5 ng/day). Among the PCBs, PCB-138 and PCB-153 were the 
      most abundant congeners (27% and 23%, respectively). p,p'-DDE, the major DDT 
      metabolite, accounted for 96% of total DDTs. Among PBDEs, BDE47 was the only 
      detected congener (present in 4% of the samples). The dietary intake of the 
      targeted compounds was lower than the intake via breast milk, suggesting that the 
      exposure from baby food was limited. In the principal component analysis, 
      chlorinated and brominated compounds were separated on principal component 1, 
      while TBP and alpha-HBCD were separated on principal component 2, likely suggesting a 
      differing emission time trend or source. PCB-153, PCB-138, trans-chlordane, 
      cis-chlordane, and trans-nonachlor were correlated with seafood consumption 
      (Spearman's rho = 0.45 to 0.57, p < 0.05), while TBP was correlated with seaweed 
      consumption (Spearman's rho = 0.46, p < 0.05). Also, four species of commercial 
      edible seaweed in Japan were analyzed to confirm the findings of the 
      duplicate-diet study. The relatively high concentration of TBP (5.5 +/- 6.6 ng/g 
      wet weight) was observed in the seaweed samples, indicating that seaweed is a 
      potential exposure source of TBP.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Fujii, Yukiko
AU  - Fujii Y
AD  - Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, 
      Belgium; Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 
      22-1 Tamagawa-cho, Minami-ku, Fukuoka, 815-8511, Japan. Electronic address: 
      yu-fujii@umin.ac.jp.
FAU - Poma, Giulia
AU  - Poma G
AD  - Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, 
      Belgium.
FAU - Malarvannan, Govindan
AU  - Malarvannan G
AD  - Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, 
      Belgium.
FAU - Soeda, Fumio
AU  - Soeda F
AD  - Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 22-1 
      Tamagawa-cho, Minami-ku, Fukuoka, 815-8511, Japan.
FAU - Toda, Akihisa
AU  - Toda A
AD  - Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 22-1 
      Tamagawa-cho, Minami-ku, Fukuoka, 815-8511, Japan.
FAU - Haraguchi, Koichi
AU  - Haraguchi K
AD  - Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, 22-1 
      Tamagawa-cho, Minami-ku, Fukuoka, 815-8511, Japan.
FAU - Covaci, Adrian
AU  - Covaci A
AD  - Toxicological Centre, University of Antwerp, Universiteitsplein 1, 2610, Wilrijk, 
      Belgium. Electronic address: adrian.covaci@uantwerpen.be.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210115
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Child, Preschool
MH  - Diet Surveys
MH  - Eating
MH  - Environmental Monitoring
MH  - *Environmental Pollutants/analysis
MH  - Female
MH  - Halogenated Diphenyl Ethers/analysis
MH  - Humans
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - Infant
MH  - Japan
MH  - Milk, Human/chemistry
MH  - *Polychlorinated Biphenyls/analysis
OTO - NOTNLM
OT  - Baby food
OT  - Dietary intake
OT  - Duplicate-diet
OT  - Edible seaweed
OT  - Japanese infants
OT  - Organohalogenated compounds
EDAT- 2021/01/19 06:00
MHDA- 2021/04/22 06:00
CRDT- 2021/01/18 20:09
PHST- 2020/10/19 00:00 [received]
PHST- 2021/01/10 00:00 [revised]
PHST- 2021/01/10 00:00 [accepted]
PHST- 2021/01/19 06:00 [pubmed]
PHST- 2021/04/22 06:00 [medline]
PHST- 2021/01/18 20:09 [entrez]
AID - S0013-9351(21)00039-6 [pii]
AID - 10.1016/j.envres.2021.110745 [doi]
PST - ppublish
SO  - Environ Res. 2021 Apr;195:110745. doi: 10.1016/j.envres.2021.110745. Epub 2021 
      Jan 15.