PMID- 33460900
OWN - NLM
STAT- MEDLINE
DCOM- 20210318
LR  - 20210318
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 271
DP  - 2021 May
TI  - Serum concentrations of persistent organic pollutants and colorectal cancer risk: 
      A case-cohort study within Korean National Cancer Center Community (KNCCC) 
      cohort.
PG  - 129596
LID - S0045-6535(21)00066-7 [pii]
LID - 10.1016/j.chemosphere.2021.129596 [doi]
AB  - BACKGROUND & AIMS: Recent prospective cohort studies have suggested that 
      circulating persistent organic pollutants (POPs) may be associated with the 
      development of cancers. We investigated the association between pre-diagnostic 
      serum concentrations of POPs and colorectal cancer (CRC) risk. METHODS: A 
      case-cohort study within a community-based prospective cohort was performed, 
      including 104 CRC cases and 235 subcohort participants. Serum concentrations of 
      POPs were measured by high resolution gas chromatography/high-resolution mass 
      spectrometry. Multivariable Cox proportional hazards regression models were used. 
      RESULTS: The association between serum concentrations of organochlorine 
      pesticides (OCs) and CRC risk was significant (cis-heptachlor epoxide: 3rd 
      tercile [HR (95% CI): 2.76 (1.25-6.07); trans-nonachlor: 2nd tercile [HR (95% 
      CI): 3.90 (1.56-9.75)], 3rd tercile [HR (95% CI): 4.86 (1.95-12.16)]); p,p'-DDD: 
      2nd tercile [HR (95% CI): 6.02 (2.05-17.70)], 3rd tercile [HR (95% CI): 7.43 
      (2.42-22.84)]). Certain polychlorinated biphenyls (PCBs) congeners were 
      significantly associated with CRC risk (PCB-105: 3rd tercile HR [95% CI]: 3.15 
      [1.38-7.19], PCB-118: 3rd tercile HR [95% CI]: 2.68 [1.22-5.92]; PCB-138: 2nd 
      tercile [HR (95% CI): 2.51 (1.19-5.28)], 3rd tercile [HR (95% CI): 3.27 
      (1.50-7.12)]; PCB-153: 2nd tercile [HR (95% CI): 3.93 (1.81-8.54)], 3rd tercile 
      [HR (95% CI): 5.02 (2.09-12.07)]; PCB-156: 2nd tercile [HR (95% CI): 2.61 
      (1.21-5.59)], 3rd tercile [HR (95% CI): 4.07 (1.73-9.61)]; PCB-180: 2nd tercile 
      [HR (95% CI): 2.58 (1.15-5.78)], 3rd tercile [HR (95% CI): 4.01 
      (1.68-9.59)]).results CONCLUSIONS: This study suggests that serum concentrations 
      of POPs could increase the CRC risk in the general population.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Park, Eun Young
AU  - Park EY
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, Republic of 
      Korea.
FAU - Kim, Jinsun
AU  - Kim J
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, Republic of 
      Korea.
FAU - Park, Eunjung
AU  - Park E
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, Republic of 
      Korea.
FAU - Oh, Jin-Kyoung
AU  - Oh JK
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, Republic of 
      Korea; Department of Cancer Control and Population Health, National Cancer Center 
      Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, 10408, 
      Republic of Korea.
FAU - Kim, Byungmi
AU  - Kim B
AD  - Division of Cancer Prevention & Early Detection, National Cancer Control 
      Institute, National Cancer Center, Goyang-si, Gyeonggi-do, 10408, Republic of 
      Korea.
FAU - Lim, Min Kyung
AU  - Lim MK
AD  - Department of Cancer Control and Population Health, National Cancer Center 
      Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, 10408, 
      Republic of Korea. Electronic address: mickey@ncc.re.kr.
LA  - eng
PT  - Journal Article
DEP - 20210108
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Cohort Studies
MH  - *Colorectal Neoplasms/chemically induced/epidemiology
MH  - *Environmental Pollutants
MH  - Humans
MH  - *Hydrocarbons, Chlorinated
MH  - Persistent Organic Pollutants
MH  - *Pesticides
MH  - *Polychlorinated Biphenyls
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
OTO - NOTNLM
OT  - Cohort
OT  - Colorectal cancer
OT  - Organochlorine pesticide
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyl
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/01/19 06:00
MHDA- 2021/03/19 06:00
CRDT- 2021/01/18 20:11
PHST- 2020/09/04 00:00 [received]
PHST- 2020/11/10 00:00 [revised]
PHST- 2021/01/04 00:00 [accepted]
PHST- 2021/01/19 06:00 [pubmed]
PHST- 2021/03/19 06:00 [medline]
PHST- 2021/01/18 20:11 [entrez]
AID - S0045-6535(21)00066-7 [pii]
AID - 10.1016/j.chemosphere.2021.129596 [doi]
PST - ppublish
SO  - Chemosphere. 2021 May;271:129596. doi: 10.1016/j.chemosphere.2021.129596. Epub 
      2021 Jan 8.