PMID- 33461438
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20211025
IS  - 1544-2217 (Electronic)
IS  - 0300-9858 (Linking)
VI  - 58
IP  - 3
DP  - 2021 May
TI  - HER2 Overexpression and Amplification in Feline Pulmonary Carcinoma.
PG  - 527-530
LID - 10.1177/0300985820988147 [doi]
AB  - HER2 is overexpressed, amplified, and mutated in a subset of human lung cancer. 
      The aim of this study was to investigate HER2 protein overexpression and gene 
      amplification in feline pulmonary carcinomas. Thirteen pulmonary carcinomas were 
      selected and TTF-1 and HER2 expression was evaluated by immunohistochemistry. 
      Fluorescence in situ hybridization (FISH) was performed with a HER2 probe and a 
      BAC probe for the feline chromosome E1p1.12-p1.11 region. Twelve adenocarcinomas 
      and 1 squamous cell carcinoma were diagnosed. TTF-1 was positive in 7 carcinomas 
      (58%). HER2 was overexpressed in 2 (15%), equivocal in 5 (38%), and negative in 6 
      cases (46%). FISH analysis of HER2 was indeterminate in 2 cases. Three pulmonary 
      carcinomas (27%) had HER2 amplification and 8 cases were not amplified (73%). The 
      significant correlation between HER2 protein overexpression and gene 
      amplification are promising preliminary data, but study of additional cases is 
      needed to confirm HER2 as a target for possible innovative treatments.
FAU - Muscatello, Luisa Vera
AU  - Muscatello LV
AUID- ORCID: 0000-0003-4653-0624
AD  - 9296University of Bologna, Bologna, Italy.
FAU - Oto, Enrico Di
AU  - Oto ED
AD  - 9296University of Bologna, Bologna, Italy.
FAU - Dignazzi, Miriam
AU  - Dignazzi M
AD  - 66220COC Farmaceutici, Sant'Agata Bolognese, Italy.
FAU - Murphy, William J
AU  - Murphy WJ
AD  - 199062Texas A&M University, College Station, TX, USA.
FAU - Porcellato, Ilaria
AU  - Porcellato I
AUID- ORCID: 0000-0003-2882-6739
AD  - 9309University of Perugia, Perugia, Italy.
FAU - De Maria, Raffaella
AU  - De Maria R
AD  - 9314University of Torino, Grugliasco, Italy.
FAU - Raudsepp, Terje
AU  - Raudsepp T
AD  - 199062Texas A&M University, College Station, TX, USA.
FAU - Foschini, Maria Pia
AU  - Foschini MP
AD  - 9296University of Bologna, Bologna, Italy.
FAU - Sforna, Monica
AU  - Sforna M
AD  - 9309University of Perugia, Perugia, Italy.
FAU - Benazzi, Cinzia
AU  - Benazzi C
AD  - 9296University of Bologna, Bologna, Italy.
FAU - Brunetti, Barbara
AU  - Brunetti B
AUID- ORCID: 0000-0002-2694-905X
AD  - 9296University of Bologna, Bologna, Italy.
LA  - eng
PT  - Journal Article
DEP - 20210119
PL  - United States
TA  - Vet Pathol
JT  - Veterinary pathology
JID - 0312020
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Animals
MH  - *Carcinoma, Squamous Cell/veterinary
MH  - *Cat Diseases/genetics
MH  - Cats
MH  - Gene Amplification
MH  - In Situ Hybridization, Fluorescence/veterinary
MH  - *Lung Neoplasms/genetics/veterinary
MH  - Receptor, ErbB-2/genetics/metabolism
OTO - NOTNLM
OT  - adenocarcinoma
OT  - amplification
OT  - cats
OT  - erbB2
OT  - fluorescence in situ hybridization
OT  - human epidermal growth factor receptor 2
OT  - immunohistochemistry
OT  - lung
OT  - overexpression
EDAT- 2021/01/20 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/01/19 05:37
PHST- 2021/01/20 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/01/19 05:37 [entrez]
AID - 10.1177/0300985820988147 [doi]
PST - ppublish
SO  - Vet Pathol. 2021 May;58(3):527-530. doi: 10.1177/0300985820988147. Epub 2021 Jan 
      19.