PMID- 33461744
OWN - NLM
STAT- MEDLINE
DCOM- 20210915
LR  - 20210915
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 56
IP  - 10
DP  - 2021 Oct
TI  - Disorders in the function of Sertoli cells and arrest in the differentiation of 
      gonocytes in patients with cryptochidism and microlithiasis.
PG  - 1886-1893
LID - S0022-3468(21)00010-5 [pii]
LID - 10.1016/j.jpedsurg.2020.12.028 [doi]
AB  - PURPOSE: This study aimed to correlate the presence of microlithiasis (ML) in 
      cryptorchidism (CO) patients with the functionality of Sertoli cells and the 
      arrest of gonocyte differentiation. METHODS: Testicular biopsies were obtained 
      from 21 inguinal CO pediatric patients and were classified in two groups as 
      follows: patients with ML and those without ML. In both groups, the number of 
      Sertoli cells/seminiferous cords and their functionality were determined, 
      considering the concentrations of inhibin B. In addition, the area and the 
      histological alterations of seminiferous epithelium were evaluated. The arrest of 
      gonocyte differentiation was determined by immunoreactivity to SALL4, AP2ɣ, PLAP 
      and POU5F1. RESULTS: We found a statistical correlation between the presence of 
      ML with the alterations in the functionality of Sertoli cells without reflecting 
      in the differentiation of the gonocytes. CONCLUSION: The study of this population 
      suggests that the association between CO and ML shows a malfunction of the 
      Sertoli cells without necessarily causing arrest in the differentiation of 
      gonocytes in these patients.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Vigueras-Villasenor, Rosa Maria
AU  - Vigueras-Villasenor RM
AD  - Laboratorio de Biologia de la Reproduccion, Instituto Nacional de Pediatria, 
      Mexico City, Mexico. Electronic address: rmvigueras@yahoo.com.mx.
FAU - Ramirez Cuevas, Zayra
AU  - Ramirez Cuevas Z
AD  - Laboratorio de Biologia de la Reproduccion, Instituto Nacional de Pediatria, 
      Mexico City, Mexico.
FAU - Chavez-Saldana, Margarita
AU  - Chavez-Saldana M
AD  - Laboratorio de Biologia de la Reproduccion, Instituto Nacional de Pediatria, 
      Mexico City, Mexico.
FAU - Landero-Huerta, Daniel Adrian
AU  - Landero-Huerta DA
AD  - Laboratorio de Biologia de la Reproduccion, Instituto Nacional de Pediatria, 
      Mexico City, Mexico.
FAU - Cuevas Alpuche, Juan Osvaldo
AU  - Cuevas Alpuche JO
AD  - Servicio de Urologia, Instituto Nacional de Pediatria, Mexico City, Mexico.
FAU - Arceo Olaiz, Ricardo Antonio
AU  - Arceo Olaiz RA
AD  - Servicio de Urologia, Instituto Nacional de Pediatria, Mexico City, Mexico.
FAU - Rojas-Castaneda, Julio Cesar
AU  - Rojas-Castaneda JC
AD  - Laboratorio de Biologia de la Reproduccion, Instituto Nacional de Pediatria, 
      Mexico City, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20210107
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
CIN - J Pediatr Surg. 2021 Jul;56(7):1256. PMID: 34011444
MH  - Cell Differentiation
MH  - Child
MH  - *Cryptorchidism
MH  - Germ Cells
MH  - Humans
MH  - Male
MH  - *Sertoli Cells
MH  - Testis
OTO - NOTNLM
OT  - Cryptorchidism
OT  - Gonocytes, inhibin B
OT  - Microlithiasis
OT  - Sertoli cells
COIS- Declaration of Competig Interest None.
EDAT- 2021/01/20 06:00
MHDA- 2021/09/16 06:00
CRDT- 2021/01/19 05:42
PHST- 2020/09/04 00:00 [received]
PHST- 2020/12/17 00:00 [revised]
PHST- 2020/12/21 00:00 [accepted]
PHST- 2021/01/20 06:00 [pubmed]
PHST- 2021/09/16 06:00 [medline]
PHST- 2021/01/19 05:42 [entrez]
AID - S0022-3468(21)00010-5 [pii]
AID - 10.1016/j.jpedsurg.2020.12.028 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2021 Oct;56(10):1886-1893. doi: 10.1016/j.jpedsurg.2020.12.028. 
      Epub 2021 Jan 7.