PMID- 33461928
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 1885-5857 (Electronic)
IS  - 1885-5857 (Linking)
VI  - 74
IP  - 11
DP  - 2021 Nov
TI  - Risk stratification of ventricular arrhythmias in repaired tetralogy of Fallot.
PG  - 935-942
LID - S1885-5857(20)30532-6 [pii]
LID - 10.1016/j.rec.2020.12.003 [doi]
AB  - INTRODUCTION AND OBJECTIVES: Risk stratification of ventricular arrhythmias in 
      patients with repaired tetralogy of Fallot (rTOF) remains unresolved. We aimed to 
      identify right ventricular (RV) electrophysiological parameters potentially 
      associated with a higher risk of ventricular arrhythmias in patients with rTOF. 
      METHODS: We included all consecutive patients with rTOF who underwent RV 
      electroanatomical mapping at a single tertiary center. We used logistic 
      regression modeling to identify those variables associated with an increased risk 
      of clinical or induced ventricular tachycardia (VT), or clinical VT exclusively. 
      RESULTS: Twenty-one of the 56 patients included had clinical or induced VT. A 
      high-frequency of premature ventricular contractions/nonsustained VT (OR, 11.34; 
      95%CI, 1.50-85.97; P=.019), an HV interval > 55 ms (OR, 21.20; 95%CI, 
      3.12-144.14; P=.002), and RV activation time (ms) (OR [per 10ms intervals], 1.34; 
      95%CI, 1.02-1.75; P=.035) proved to be associated with clinical or induced VT. 
      The model including this information had good discrimination ability, with an 
      area under the curve of 0.884 (95%CI, 0.79-0.97; P <.001). When considering only 
      clinical VT as the outcome of interest, only an HV interval > 55ms (OR, 9.65; 
      95%CI, 1.41-66.14; P=.021) and high-frequency of premature ventricular 
      contractions/nonsustained VT (OR, 13.14; 95%CI, 1.95-88.54; P=.008) were 
      independently associated (area under the curve of 0.836 [95%CI, 0.663-1.000; 
      P=.002]). CONCLUSIONS: High-frequency of premature ventricular 
      contractions/nonsustained VT, an HV interval> 55ms and RV activation time are 
      factors associated with an increased risk of ventricular arrhythmias in patients 
      with rTOF.
CI  - Copyright (c) 2020 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, 
      S.L.U. All rights reserved.
FAU - Rivas-Gandara, Nuria
AU  - Rivas-Gandara N
AD  - Unidad de Arritmias, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Facultat Medicina i Cirurgia. Universitat Autonoma de 
      Barcelona (UAB), Barcelona, Spain; Institut de Recerca Vall d'Hebron (VHIR), 
      Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades 
      Cardiovasculares (CIBERCV), Spain. Electronic address: nrivas@vhebron.net.
FAU - Francisco-Pascual, Jaume
AU  - Francisco-Pascual J
AD  - Unidad de Arritmias, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Facultat Medicina i Cirurgia. Universitat Autonoma de 
      Barcelona (UAB), Barcelona, Spain; Institut de Recerca Vall d'Hebron (VHIR), 
      Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades 
      Cardiovasculares (CIBERCV), Spain.
FAU - Pijuan-Domenech, Antonia
AU  - Pijuan-Domenech A
AD  - Facultat Medicina i Cirurgia. Universitat Autonoma de Barcelona (UAB), Barcelona, 
      Spain; Institut de Recerca Vall d'Hebron (VHIR), Barcelona, Spain; Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; 
      Unidad Integrada de Cardiopatias Congenitas del Hospital Universitario Vall 
      d'Hebron-Hospital Sant Pau, Barcelona, Spain.
FAU - Ribera-Sole, Aida
AU  - Ribera-Sole A
AD  - Facultat Medicina i Cirurgia. Universitat Autonoma de Barcelona (UAB), Barcelona, 
      Spain; Institut de Recerca Vall d'Hebron (VHIR), Barcelona, Spain; Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; 
      Unidad de Epidemiologia, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Centro de Investigacion Biomedica en Red de 
      Epidemiologia y Salud Publica (CIBERESP), Spain.
FAU - Dos-Subira, Laura
AU  - Dos-Subira L
AD  - Facultat Medicina i Cirurgia. Universitat Autonoma de Barcelona (UAB), Barcelona, 
      Spain; Institut de Recerca Vall d'Hebron (VHIR), Barcelona, Spain; Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; 
      Unidad Integrada de Cardiopatias Congenitas del Hospital Universitario Vall 
      d'Hebron-Hospital Sant Pau, Barcelona, Spain.
FAU - Benito, Begona
AU  - Benito B
AD  - Unidad de Arritmias, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Facultat Medicina i Cirurgia. Universitat Autonoma de 
      Barcelona (UAB), Barcelona, Spain; Institut de Recerca Vall d'Hebron (VHIR), 
      Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades 
      Cardiovasculares (CIBERCV), Spain.
FAU - Terricabras, Maria
AU  - Terricabras M
AD  - Unidad de Arritmias, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Facultat Medicina i Cirurgia. Universitat Autonoma de 
      Barcelona (UAB), Barcelona, Spain; Institut de Recerca Vall d'Hebron (VHIR), 
      Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades 
      Cardiovasculares (CIBERCV), Spain.
FAU - Perez-Rodon, Jordi
AU  - Perez-Rodon J
AD  - Unidad de Arritmias, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Facultat Medicina i Cirurgia. Universitat Autonoma de 
      Barcelona (UAB), Barcelona, Spain; Institut de Recerca Vall d'Hebron (VHIR), 
      Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades 
      Cardiovasculares (CIBERCV), Spain.
FAU - Subirana, Maria Teresa
AU  - Subirana MT
AD  - Unidad Integrada de Cardiopatias Congenitas del Hospital Universitario Vall 
      d'Hebron-Hospital Sant Pau, Barcelona, Spain.
FAU - Santos-Ortega, Alba
AU  - Santos-Ortega A
AD  - Unidad de Arritmias, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Facultat Medicina i Cirurgia. Universitat Autonoma de 
      Barcelona (UAB), Barcelona, Spain; Institut de Recerca Vall d'Hebron (VHIR), 
      Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades 
      Cardiovasculares (CIBERCV), Spain.
FAU - Roses-Noguer, Ferran
AU  - Roses-Noguer F
AD  - Unidad de Arritmias, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Facultat Medicina i Cirurgia. Universitat Autonoma de 
      Barcelona (UAB), Barcelona, Spain; Institut de Recerca Vall d'Hebron (VHIR), 
      Barcelona, Spain.
FAU - Miranda, Berta
AU  - Miranda B
AD  - Facultat Medicina i Cirurgia. Universitat Autonoma de Barcelona (UAB), Barcelona, 
      Spain; Institut de Recerca Vall d'Hebron (VHIR), Barcelona, Spain; Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; 
      Unidad Integrada de Cardiopatias Congenitas del Hospital Universitario Vall 
      d'Hebron-Hospital Sant Pau, Barcelona, Spain.
FAU - Moya-Mitjans, Angel
AU  - Moya-Mitjans A
AD  - Unidad de Arritmias, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Facultat Medicina i Cirurgia. Universitat Autonoma de 
      Barcelona (UAB), Barcelona, Spain; Institut de Recerca Vall d'Hebron (VHIR), 
      Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades 
      Cardiovasculares (CIBERCV), Spain.
FAU - Ferreira-Gonzalez, Ignacio
AU  - Ferreira-Gonzalez I
AD  - Facultat Medicina i Cirurgia. Universitat Autonoma de Barcelona (UAB), Barcelona, 
      Spain; Institut de Recerca Vall d'Hebron (VHIR), Barcelona, Spain; Centro de 
      Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; 
      Unidad de Epidemiologia, Servicio de Cardiologia, Hospital Universitario Vall 
      d'Hebron, Barcelona, Spain; Centro de Investigacion Biomedica en Red de 
      Epidemiologia y Salud Publica (CIBERESP), Spain.
LA  - eng
LA  - spa
PT  - Journal Article
DEP - 20210116
PL  - Spain
TA  - Rev Esp Cardiol (Engl Ed)
JT  - Revista espanola de cardiologia (English ed.)
JID - 101587954
SB  - IM
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Risk Assessment
MH  - *Tachycardia, Ventricular/diagnosis/epidemiology/etiology
MH  - *Tetralogy of Fallot/surgery
MH  - *Ventricular Premature Complexes/diagnosis/epidemiology/etiology
OTO - NOTNLM
OT  - Arrhythmia
OT  - Arritmia
OT  - Cardiopatia congenita
OT  - Congenital heart disease
OT  - Mapeo ventricular
OT  - Muerte subita cardiaca
OT  - Sudden cardiac death
OT  - Taquicardia ventricular
OT  - Tetralogy of Fallot
OT  - Tetralogia de Fallot
OT  - Ventricular mapping
OT  - Ventricular tachycardia
EDAT- 2021/01/20 06:00
MHDA- 2021/11/03 06:00
CRDT- 2021/01/19 05:44
PHST- 2020/06/14 00:00 [received]
PHST- 2020/12/01 00:00 [accepted]
PHST- 2021/01/20 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/01/19 05:44 [entrez]
AID - S1885-5857(20)30532-6 [pii]
AID - 10.1016/j.rec.2020.12.003 [doi]
PST - ppublish
SO  - Rev Esp Cardiol (Engl Ed). 2021 Nov;74(11):935-942. doi: 
      10.1016/j.rec.2020.12.003. Epub 2021 Jan 16.