PMID- 33463161
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 6
IP  - 6
DP  - 2020 Jun 8
TI  - pH/GSH-Dual-Sensitive Hollow Mesoporous Silica Nanoparticle-Based Drug Delivery 
      System for Targeted Cancer Therapy.
PG  - 3375-3387
LID - 10.1021/acsbiomaterials.0c00073 [doi]
AB  - The purpose of developing novel anticancer drug delivery systems (DDSs) is to 
      efficiently carry and release drugs into cancer cells and minimize side effects. 
      In this work, based on hollow mesoporous silica nanoparticle (HMSN) and the 
      charge-reversal property, a pH/GSH-dual-sensitive DDS named DOX@HMSN-SS-PLL(cit) 
      was reported. HMSN encapsulated DOX with high efficacy and was then covered by 
      the "gatekeeper" beta-cyclodextrin (beta-CD) through the glutathione (GSH)-sensitive 
      disulfide bond. Thereafter, adamantine-blocked 
      citraconic-anhydride-functionalized poly-l-lysine (PLL(cit)-Ad) was decorated on 
      the surface of the particles via host-guest interaction. The negatively charged 
      carriers were stable in the neutral environment in vivo and could be effectively 
      transported to the tumor site. The surface charge of the nanoparticles could be 
      reversed in the weakly acidic environment, which increased the cellular uptake 
      ability of the carriers by the cancer cells. After cellular internalization, beta-CD 
      can be removed by breakage of the disulfide bond in the presence of a high 
      concentration of GSH, leading to DOX release. The preparation process of the 
      carriers was monitored. The charge-reversal capability and the controlled 
      drug-release behavior of the carriers were also investigated. In vitro and in 
      vivo experiments demonstrated the excellent cancer therapy effect with low side 
      effects of the carriers. It is expected that dual-sensitive DOX@HMSN-SS-PLL(cit) 
      could play an important role in cancer therapy.
FAU - Chen, Zhongyin
AU  - Chen Z
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Wan, Lihui
AU  - Wan L
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Yuan, Ye
AU  - Yuan Y
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei430022, China.
FAU - Kuang, Ying
AU  - Kuang Y
AD  - Glyn O. Philips Hydrocolloid Research Centre at HUT, Hubei University of 
      Technology, Wuhan, Hubei 430068, China.
FAU - Xu, Xiangyu
AU  - Xu X
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Liao, Tao
AU  - Liao T
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Liu, Jia
AU  - Liu J
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      Hubei430022, China.
FAU - Xu, Zi-Qiang
AU  - Xu ZQ
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Jiang, Bingbing
AU  - Jiang B
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
FAU - Li, Cao
AU  - Li C
AUID- ORCID: 0000-0002-3500-340X
AD  - Ministry-of-Education Key Laboratory for the Green Preparation and Application of 
      Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei 
      University, Wuhan 430062, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200508
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 80168379AG (Doxorubicin)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Doxorubicin/therapeutic use
MH  - Drug Delivery Systems
MH  - Glutathione/therapeutic use
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - *Nanoparticles
MH  - *Neoplasms/drug therapy
MH  - Porosity
MH  - Silicon Dioxide/therapeutic use
OTO - NOTNLM
OT  - anticancer drug delivery system
OT  - charge-reversal property
OT  - controlled release
OT  - hollow mesoporous silica nanoparticle
OT  - pH/GSH-dual-sensitivity
EDAT- 2021/01/20 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/01/19 08:39
PHST- 2021/01/19 08:39 [entrez]
PHST- 2021/01/20 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - 10.1021/acsbiomaterials.0c00073 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2020 Jun 8;6(6):3375-3387. doi: 
      10.1021/acsbiomaterials.0c00073. Epub 2020 May 8.