PMID- 33465682
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20211117
IS  - 1879-0593 (Electronic)
IS  - 1368-8375 (Linking)
VI  - 114
DP  - 2021 Mar
TI  - Difference in tumor mutation burden between squamous cell carcinoma in the oral 
      cavity and larynx.
PG  - 105142
LID - S1368-8375(20)30578-9 [pii]
LID - 10.1016/j.oraloncology.2020.105142 [doi]
AB  - OBJECTIVES: This study aimed to evaluate the difference in tumor mutation burden 
      (TMB) between oral cavity squamous cell carcinoma (OCSCC) and larynx squamous 
      cell carcinoma (LSCC). MATERIALS AND METHODS: Patients with OCSCC or LSCC were 
      identified from datasets within The Cancer Genome Atlas. Somatic mutations and 
      clinical information were included in the analysis. A Poisson regression model 
      was used to evaluate the association of TMB with the primary cancer sites. 
      RESULTS: We identified 5 datasets that included 396 OCSCC patients and 143 LSCC 
      patients. Patients with LSCC had a significantly higher TMB than patients with 
      OCSCC (crude risk ratio: 0.60, 95% confidence interval: 0.51-0.70, P < 0.001; 
      adjusted risk ratio: 0.57, 95% confidence interval: 0.49-0.66, 
      P < 0.001).Subgroup analyses suggested that this difference was independent of 
      dataset, age, sex, race, alcohol drinking, smoking status, pathological risk, 
      tumor grade, and tumor stage. Sensitivity analyses confirmed the robustness of 
      this finding. CONCLUSION: To the best of our knowledge, this is the first study 
      to identify a significant difference in TMB between OCSCC and LSCC. Though 
      preliminary, these findings might have implications for guiding the development 
      of trials for examining the response of head and neck carcinomas to immune 
      checkpoint inhibitor treatments.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Cui, Jiuwei
AU  - Cui J
AD  - Cancer Center, The First Hospital of Jilin University, 71 Xinmin Ave, Changchun, 
      China. Electronic address: jiuwei_cui@aliyun.com.
FAU - Wang, Daguang
AU  - Wang D
AD  - Department of Gastrointestinal Colorectal and Anal Surgery, The First Hospital of 
      Jilin University, 71 Xinmin Ave, Changchun, China. Electronic address: 
      daguang_wang@aliyun.com.
FAU - Nie, Deheng
AU  - Nie D
AD  - Cancer Center, The First Hospital of Jilin University, 71 Xinmin Ave, Changchun, 
      China. Electronic address: deheng_nie@163.com.
FAU - Liu, Wenhui
AU  - Liu W
AD  - Cancer Center, The First Hospital of Jilin University, 71 Xinmin Ave, Changchun, 
      China. Electronic address: wenhuiliu2018@163.com.
FAU - Sun, Meiting
AU  - Sun M
AD  - Cancer Center, The First Hospital of Jilin University, 71 Xinmin Ave, Changchun, 
      China. Electronic address: meiting_sun@aliyun.com.
FAU - Pei, Fengli
AU  - Pei F
AD  - Cancer Center, The First Hospital of Jilin University, 71 Xinmin Ave, Changchun, 
      China. Electronic address: fengli_pei@aliyun.com.
FAU - Han, Fujun
AU  - Han F
AD  - Cancer Center, The First Hospital of Jilin University, 71 Xinmin Ave, Changchun, 
      China. Electronic address: fujunhan@jlu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210116
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*physiopathology
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/pathology
MH  - Male
MH  - Mouth Neoplasms/*physiopathology
MH  - Mutation
OTO - NOTNLM
OT  - Head and neck
OT  - Larynx
OT  - Oral cavity
OT  - Squamous cell carcinoma
OT  - Tumor mutation burden
EDAT- 2021/01/20 06:00
MHDA- 2021/11/18 06:00
CRDT- 2021/01/19 20:12
PHST- 2020/08/12 00:00 [received]
PHST- 2020/11/24 00:00 [revised]
PHST- 2020/12/08 00:00 [accepted]
PHST- 2021/01/20 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2021/01/19 20:12 [entrez]
AID - S1368-8375(20)30578-9 [pii]
AID - 10.1016/j.oraloncology.2020.105142 [doi]
PST - ppublish
SO  - Oral Oncol. 2021 Mar;114:105142. doi: 10.1016/j.oraloncology.2020.105142. Epub 
      2021 Jan 16.