PMID- 33465859
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210120
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 2
IP  - 4
DP  - 2016 Apr 11
TI  - Polymer-Based Local Antibiotic Delivery for Prevention of Polymicrobial Infection 
      in Contaminated Mandibular Implants.
PG  - 558-566
LID - 10.1021/acsbiomaterials.5b00545 [doi]
AB  - Antibiotic-releasing porous poly(methyl methacrylate) (PMMA) space maintainers, 
      comprising PMMA with an aqueous porogen and a poly(DL-lactic-co-glycolic acid) 
      (PLGA) antibiotic carrier, have been developed to facilitate local delivery of 
      antibiotics and tissue integration. In this study, clindamycin-loaded space 
      maintainers were used to investigate the effects of antibiotic release kinetics 
      and dose upon bacterial clearance and bone and soft tissue healing in a 
      pathogen-contaminated rabbit mandibular defect. Three formulations were 
      fabricated for either high dose burst release (7 days) or with PLGA 
      microparticles for extended release (28 days) at high and low dose. Although 
      inoculated bacteria were not recovered from any specimens, the burst release 
      formulation showed less inflammation and fibrous capsule formation and more bone 
      formation close to the implant than the low dose extended release formulation by 
      histologic analysis. These results suggest that local antibiotic release kinetics 
      and dose affect soft and hard tissue healing independent from its ability to 
      clear bacteria.
FAU - Shah, Sarita R
AU  - Shah SR
AD  - Department of Bioengineering, Rice University, Houston, Texas 77030, United 
      States.
FAU - Tatara, Alexander M
AU  - Tatara AM
AD  - Department of Bioengineering, Rice University, Houston, Texas 77030, United 
      States.
FAU - Lam, Johnny
AU  - Lam J
AD  - Department of Bioengineering, Rice University, Houston, Texas 77030, United 
      States.
FAU - Lu, Steven
AU  - Lu S
AD  - Department of Bioengineering, Rice University, Houston, Texas 77030, United 
      States.
FAU - Scott, David W
AU  - Scott DW
AD  - Department of Statistics, Rice University, Houston, Texas 77251, United States.
FAU - Bennett, George N
AU  - Bennett GN
AD  - Department of BioSciences, Rice University, Houston, Texas 77005, United States.
FAU - van den Beucken, Jeroen J J P
AU  - van den Beucken JJJP
AD  - Radboud University Medical Center, Nijmegen, The Netherlands.
FAU - Jansen, John A
AU  - Jansen JA
AD  - Radboud University Medical Center, Nijmegen, The Netherlands.
FAU - Wong, Mark E
AU  - Wong ME
AD  - University of Texas Health Science Center at Houston, Houston, Texas 77030, 
      United States.
FAU - Mikos, Antonios G
AU  - Mikos AG
AD  - Department of Bioengineering, Rice University, Houston, Texas 77030, United 
      States.
LA  - eng
PT  - Journal Article
DEP - 20160324
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - PLGA
OT  - PMMA
OT  - controlled antibiotic release
OT  - odontogenic infection
OT  - osteomyelitis
EDAT- 2016/04/11 00:00
MHDA- 2016/04/11 00:01
CRDT- 2021/01/20 01:00
PHST- 2021/01/20 01:00 [entrez]
PHST- 2016/04/11 00:00 [pubmed]
PHST- 2016/04/11 00:01 [medline]
AID - 10.1021/acsbiomaterials.5b00545 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2016 Apr 11;2(4):558-566. doi: 
      10.1021/acsbiomaterials.5b00545. Epub 2016 Mar 24.