PMID- 33465891
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210120
IS  - 2373-9878 (Electronic)
IS  - 2373-9878 (Linking)
VI  - 2
IP  - 12
DP  - 2016 Dec 12
TI  - Nanoparticle-Facilitated Membrane Depolarization-Induced Receptor Activation: 
      Implications on Cellular Uptake and Drug Delivery.
PG  - 2153-2161
LID - 10.1021/acsbiomaterials.6b00338 [doi]
AB  - Cell-specific uptake of drug delivery systems (DDSs) are crucial to achieve 
      optimal efficacy of many drugs. Widely employed strategies to facilitate targeted 
      intracellular drug delivery involves attachment of targeting ligands (peptides or 
      antibodies) to DDSs. Target receptors mutations can limit the effectiveness of 
      this approach. Herein, we demonstrate, through in vitro inhibitory and drug 
      delivery studies, that graphene nanoribbons (GNRs), water dispersed with the 
      amphiphilic polymer called PEG-DSPE ((1, 
      2-distearoyl-sn-glycero-3-phosphoethanolamine-N [amino (polyethylene glycol)]) 
      (induce membrane depolarization-mediated epidermal growth factor receptor (EGFR) 
      activation. This phenomenon is ligand-independent and EGFR activation occurs via 
      influx of Ca(2+) ions from the extracellular space. We further provide evidence, 
      through in vivo studies, that this mechanism could be exploited to facilitate 
      efficacious drug delivery into tumors that overexpress EGFR. The results suggest 
      that transient membrane depolarization-facilitated cell receptor activation can 
      be employed as an alternate strategy for enhanced intracellular drug delivery.
FAU - Chowdhury, Sayan Mullick
AU  - Chowdhury SM
AD  - Department of Biomedical Engineering, Stony Brook University, Stony Brook, New 
      York 11794, United States.
FAU - Xie, Shawn
AU  - Xie S
AD  - Department of Biomedical Engineering, Stony Brook University, Stony Brook, New 
      York 11794, United States.
FAU - Fang, Justin
AU  - Fang J
AD  - Department of Biomedical Engineering, Stony Brook University, Stony Brook, New 
      York 11794, United States.
FAU - Lee, Stephen K
AU  - Lee SK
AD  - Department of Biomedical Engineering, Stony Brook University, Stony Brook, New 
      York 11794, United States.
FAU - Sitharaman, Balaji
AU  - Sitharaman B
AD  - Department of Biomedical Engineering, Stony Brook University, Stony Brook, New 
      York 11794, United States.
LA  - eng
PT  - Journal Article
DEP - 20161028
PL  - United States
TA  - ACS Biomater Sci Eng
JT  - ACS biomaterials science & engineering
JID - 101654670
SB  - IM
OTO - NOTNLM
OT  - cancer
OT  - drug delivery
OT  - graphene nanoribbons
OT  - membrane depolarization
OT  - targeting
EDAT- 2016/12/12 00:00
MHDA- 2016/12/12 00:01
CRDT- 2021/01/20 01:00
PHST- 2021/01/20 01:00 [entrez]
PHST- 2016/12/12 00:00 [pubmed]
PHST- 2016/12/12 00:01 [medline]
AID - 10.1021/acsbiomaterials.6b00338 [doi]
PST - ppublish
SO  - ACS Biomater Sci Eng. 2016 Dec 12;2(12):2153-2161. doi: 
      10.1021/acsbiomaterials.6b00338. Epub 2016 Oct 28.