PMID- 33467722
OWN - NLM
STAT- MEDLINE
DCOM- 20210423
LR  - 20210423
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 2
DP  - 2021 Jan 15
TI  - The Effect of Hypoxia on the Expression of CXC Chemokines and CXC Chemokine 
      Receptors-A Review of Literature.
LID - 10.3390/ijms22020843 [doi]
LID - 843
AB  - Hypoxia is an integral component of the tumor microenvironment. Either as chronic 
      or cycling hypoxia, it exerts a similar effect on cancer processes by activating 
      hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-kappaB), with cycling 
      hypoxia showing a stronger proinflammatory influence. One of the systems affected 
      by hypoxia is the CXC chemokine system. This paper reviews all available 
      information on hypoxia-induced changes in the expression of all CXC chemokines 
      (CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8 (IL-8), CXCL9, CXCL10, 
      CXCL11, CXCL12 (SDF-1), CXCL13, CXCL14, CXCL15, CXCL16, CXCL17) as well as CXC 
      chemokine receptors-CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, CXCR7 and CXCR8. 
      First, we present basic information on the effect of these chemoattractant 
      cytokines on cancer processes. We then discuss the effect of hypoxia-induced 
      changes on CXC chemokine expression on the angiogenesis, lymphangiogenesis and 
      recruitment of various cells to the tumor niche, including myeloid-derived 
      suppressor cells (MDSCs), tumor-associated macrophages (TAMs), tumor-associated 
      neutrophils (TANs), regulatory T cells (T(regs)) and tumor-infiltrating 
      lymphocytes (TILs). Finally, the review summarizes data on the use of drugs 
      targeting the CXC chemokine system in cancer therapies.
FAU - Korbecki, Jan
AU  - Korbecki J
AUID- ORCID: 0000-0003-1642-1259
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University 
      in Szczecin, Powstancow Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
FAU - Kojder, Klaudyna
AU  - Kojder K
AD  - Department of Anaesthesiology and Intensive Care, Pomeranian Medical University 
      in Szczecin, Unii Lubelskiej 1, 71-281 Szczecin, Poland.
FAU - Kapczuk, Patrycja
AU  - Kapczuk P
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University 
      in Szczecin, Powstancow Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
FAU - Kupnicka, Patrycja
AU  - Kupnicka P
AUID- ORCID: 0000-0002-0756-6483
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University 
      in Szczecin, Powstancow Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
FAU - Gawronska-Szklarz, Barbara
AU  - Gawronska-Szklarz B
AUID- ORCID: 0000-0002-8805-7217
AD  - Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian 
      Medical University in Szczecin, Powstancow Wielkopolskich 72 Av., 70-111 
      Szczecin, Poland.
FAU - Gutowska, Izabela
AU  - Gutowska I
AUID- ORCID: 0000-0001-8823-0473
AD  - Department of Medical Chemistry, Pomeranian Medical University in Szczecin, 
      Powstancow Wlkp. 72 Av., 70-111 Szczecin, Poland.
FAU - Chlubek, Dariusz
AU  - Chlubek D
AUID- ORCID: 0000-0003-4497-4395
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University 
      in Szczecin, Powstancow Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
FAU - Baranowska-Bosiacka, Irena
AU  - Baranowska-Bosiacka I
AUID- ORCID: 0000-0001-9187-8895
AD  - Department of Biochemistry and Medical Chemistry, Pomeranian Medical University 
      in Szczecin, Powstancow Wielkopolskich 72 Av., 70-111 Szczecin, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210115
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Chemokines, CXC)
RN  - 0 (Chemotactic Factors)
RN  - 0 (Cytokines)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (NF-kappa B p50 Subunit)
RN  - 0 (NFKB1 protein, human)
RN  - 0 (Receptors, CXCR)
SB  - IM
MH  - Chemokines, CXC/*metabolism
MH  - Chemotactic Factors/metabolism
MH  - Cytokines/metabolism
MH  - Endothelial Cells/metabolism
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - *Hypoxia
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/metabolism
MH  - Inflammation
MH  - Microcirculation
MH  - NF-kappa B p50 Subunit/metabolism
MH  - Neoplasms/*drug therapy/*metabolism
MH  - Receptors, CXCR/*metabolism
PMC - PMC7830156
OTO - NOTNLM
OT  - CXC chemokine
OT  - HIF-1alpha
OT  - IL-8
OT  - NF-kappaB
OT  - SDF-1
OT  - cancer
OT  - cycling hypoxia
OT  - hypoxia
OT  - hypoxia-inducible factor
OT  - tumor
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/21 06:00
MHDA- 2021/04/24 06:00
PMCR- 2021/01/15
CRDT- 2021/01/20 01:09
PHST- 2020/12/09 00:00 [received]
PHST- 2021/01/06 00:00 [revised]
PHST- 2021/01/12 00:00 [accepted]
PHST- 2021/01/20 01:09 [entrez]
PHST- 2021/01/21 06:00 [pubmed]
PHST- 2021/04/24 06:00 [medline]
PHST- 2021/01/15 00:00 [pmc-release]
AID - ijms22020843 [pii]
AID - ijms-22-00843 [pii]
AID - 10.3390/ijms22020843 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Jan 15;22(2):843. doi: 10.3390/ijms22020843.