PMID- 33468370
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 1769-7131 (Electronic)
IS  - 0987-7053 (Linking)
VI  - 51
IP  - 2
DP  - 2021 Mar
TI  - Comparison of figure-of-8 and circular coils for threshold tracking transcranial 
      magnetic stimulation measurements.
PG  - 153-160
LID - S0987-7053(21)00002-2 [pii]
LID - 10.1016/j.neucli.2021.01.001 [doi]
AB  - OBJECTIVES: The transcranial magnetic stimulation (TMS) technique of 
      threshold-tracking short-interval intracortical inhibition (T-SICI) has been 
      proposed as a diagnostic tool for amyotrophic lateral sclerosis (ALS). Most of 
      these studies have used a circular coil, whereas a figure-of-8 coil is usually 
      recommended for paired-pulse TMS measurements. The aim of this study was to 
      compare figure-of-8 and circular coils for T-SICI in the upper limb, with special 
      attention to reproducibility, and the pain or discomfort experienced by the 
      subjects. METHODS: Twenty healthy subjects (aged: 45.5 +/- 6.7, mean +/- SD, 9 
      females, 11 males) underwent two examinations with each coil, in morning and 
      afternoon sessions on the same day, with T-SICI measured at interstimulus 
      intervals (ISIs) from 1-7 ms. After each examination the subjects rated degree of 
      pain/discomfort from 0 to 10 using a numerical rating scale (NRS). RESULTS: Mean 
      T-SICI was higher for the figure-of-8 than for the circular coil at ISI of 2 ms 
      (p < 0.05) but did not differ at other ISIs. Intra-subject variability did not 
      differ between coils, but mean inhibition from 1-3.5 ms was less variable between 
      subjects with the figure-of-8 coil (SD 7.2% vs. 11.2% RMT, p < 0.05), and no such 
      recordings were without inhibition (vs. 6 with the circular coil). The subjects 
      experienced less pain/discomfort with the figure-of-8 coil (mean NRS: 1.9 +/- 1.28 
      vs 2.8 +/- 1.60, p < 0.005). DISCUSSION: The figure-of-8 coil may have better 
      applicability in patients, due to the lower incidence of lack of inhibition in 
      healthy subjects, and the lower experience of pain or discomfort.
CI  - Copyright (c) 2021 Elsevier Masson SAS. All rights reserved.
FAU - Orskov, Soren
AU  - Orskov S
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark.
FAU - Bostock, Hugh
AU  - Bostock H
AD  - Department of Clinical Neurophysiology, National Hospital for Neurology and 
      Neurosurgery, Queen Square, WC1N 3BG, London, United Kingdom.
FAU - Howells, James
AU  - Howells J
AD  - Central Clinical School, Faculty of Medicine and Health, University of Sydney, 
      Sydney, Australia.
FAU - Pugdahl, Kirsten
AU  - Pugdahl K
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark.
FAU - Fuglsang-Frederiksen, Anders
AU  - Fuglsang-Frederiksen A
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark.
FAU - Nielsen, Christina Shen-Zhuang
AU  - Nielsen CS
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark.
FAU - Cengiz, Bulent
AU  - Cengiz B
AD  - Department of Neurology, Gazi University Faculty of Medicine, Besevler, 06500, 
      Ankara, Turkey.
FAU - Samusyte, Gintaute
AU  - Samusyte G
AD  - Department of Neurology, Medical Academy, Lithuanian University of Health 
      Sciences, Kaunas, Lithuania.
FAU - Koltzenburg, Martin
AU  - Koltzenburg M
AD  - Department of Clinical Neurophysiology, National Hospital for Neurology and 
      Neurosurgery, Queen Square, WC1N 3BG, London, United Kingdom; Sobell Department 
      of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen 
      Square, WC1N 3BG, London, United Kingdom.
FAU - Tankisi, Hatice
AU  - Tankisi H
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus, 
      Denmark. Electronic address: hatitank@rm.dk.
LA  - eng
GR  - MR/K015222/1/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
DEP - 20210116
PL  - France
TA  - Neurophysiol Clin
JT  - Neurophysiologie clinique = Clinical neurophysiology
JID - 8804532
SB  - IM
MH  - Adult
MH  - Evoked Potentials, Motor
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Motor Cortex
MH  - Neural Inhibition
MH  - Reproducibility of Results
MH  - *Transcranial Magnetic Stimulation
OTO - NOTNLM
OT  - Circular coil
OT  - Figure-of-8 coil
OT  - SICI
OT  - Short interval intracortical inhibition
OT  - TMS
OT  - Threshold tracking
OT  - Transcranial magnetic stimulation
EDAT- 2021/01/21 06:00
MHDA- 2021/09/18 06:00
CRDT- 2021/01/20 05:41
PHST- 2020/11/09 00:00 [received]
PHST- 2021/01/05 00:00 [revised]
PHST- 2021/01/05 00:00 [accepted]
PHST- 2021/01/21 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
PHST- 2021/01/20 05:41 [entrez]
AID - S0987-7053(21)00002-2 [pii]
AID - 10.1016/j.neucli.2021.01.001 [doi]
PST - ppublish
SO  - Neurophysiol Clin. 2021 Mar;51(2):153-160. doi: 10.1016/j.neucli.2021.01.001. 
      Epub 2021 Jan 16.