PMID- 33468422
OWN - NLM
STAT- MEDLINE
DCOM- 20220325
LR  - 20220325
IS  - 1878-0938 (Electronic)
IS  - 1878-0938 (Linking)
VI  - 34
DP  - 2022 Jan
TI  - Saline as an Alternative to Radio-Contrast for Optical Coherence 
      Tomography-Guided Percutaneous Coronary Intervention: A Prospective Comparison.
PG  - 86-91
LID - S1553-8389(21)00013-0 [pii]
LID - 10.1016/j.carrev.2021.01.010 [doi]
AB  - OBJECTIVES: To do a quantitative comparison of saline and contrast Frequency 
      domain optical coherence tomography (FD-OCT) during percutaneous coronary 
      intervention (PCI) optimisation. METHODS: 13 pairs of OCT runs were analysed, 
      wherein each pair consisted of a contrast run and a heparinized saline run taken 
      in the same coronary artery at the same position. Quantitative analysis was done 
      comparing minimal lumen area (MLA), proximal reference diameter (PRD), distal 
      reference diameter (DRD) and percentage area stenosis (AS) at the same anatomical 
      location. Lesion morphologies, rendered stent view and 3D reconstruction were 
      compared for image clarity. RESULT: The saline OCT runs resulted in comparable 
      MLA (3.88 +/- 2.59 mm(2) with saline run vs 3.88 +/- 2.71 mm(2) with contrast run; 
      p = 0.650), PRD (3.66 +/- 0.52 mm with saline vs 3.65 +/- 0.52 mm with contrast; 
      p = 0.463), DRD (2.97 +/- 0.22 mm with saline vs 2.99 +/- 0.88 mm with contrast; 
      p = 0.433), and AS (59.60 +/- 18.62% with saline vs 59.18 +/- 19.11% with contrast; 
      p = 0.753) with respect to the contrast runs. The Bland Altman plots of the 
      measured parameters indicate good agreement between saline and contrast OCT. 
      Linear regression analysis indicated the absence of proportional bias All lesion 
      morphologies (calcified, fibrotic, thin cap fibroatheroma, macrophages, 
      cholesterol crystals and edge dissection), 3D reconstruction and rendered stent 
      view were clearly demonstrable in the saline OCT runs. CONCLUSIONS: Using 
      heparinized saline as flushing media in coronary FD-OCT may result in vessel 
      dimensions that are comparable with contrast. Heparinized saline may be used as a 
      contrast saving alternative for FD-OCT during PCI optimization.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Gupta, Ankush
AU  - Gupta A
AD  - Professor of Medicine & Interventional Cardiologist, Head of Department 
      (Cardiology), Military Hospital Jaipur, Rajasthan 302016, India. Electronic 
      address: drankushgupta@gmail.com.
FAU - Chhikara, Sanya
AU  - Chhikara S
AD  - VMMC & Safdarjung Hospital, New Delhi 110029, India.
FAU - Vijayvergiya, Rajesh
AU  - Vijayvergiya R
AD  - Department of Cardiology, Advanced Cardiac Centre, PGIMER, Chandigarh 160012, 
      India.
FAU - Seth, Ashok
AU  - Seth A
AD  - Fortis Escorts Heart Institute, New Delhi 110025, India. Electronic address: 
      ashok.seth@fortishealthcare.com.
FAU - Mahesh, Nalin K
AU  - Mahesh NK
AD  - Department of Cardiology, INHS Asvini, Mumbai, Maharashtra 400005, India.
FAU - Akasaka, Takashi
AU  - Akasaka T
AD  - Department of Cardiovascular Medicine, Wakayama Medical University, Kimiidera 
      811-1, Wakayama 641-8509, Japan. Electronic address: akasat@wakayama-med.ac.jp.
FAU - Singh, Navreet
AU  - Singh N
AD  - Department of Cardiology, The Air Force Central Medical Establishment, New Delhi 
      110010, India.
LA  - eng
PT  - Journal Article
DEP - 20210114
PL  - United States
TA  - Cardiovasc Revasc Med
JT  - Cardiovascular revascularization medicine : including molecular interventions
JID - 101238551
SB  - IM
MH  - Constriction, Pathologic
MH  - Coronary Angiography
MH  - *Coronary Artery Disease/diagnostic imaging/pathology/therapy
MH  - Coronary Vessels/diagnostic imaging/pathology
MH  - Humans
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Tomography, Optical Coherence
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Contrast
OT  - Heparinized saline
OT  - Intracoronary imaging
OT  - OCT
OT  - Optical coherence tomography
OT  - Percutaneous coronary intervention
COIS- Declaration of competing interest None.
EDAT- 2021/01/21 06:00
MHDA- 2022/03/26 06:00
CRDT- 2021/01/20 05:42
PHST- 2020/09/26 00:00 [received]
PHST- 2021/01/09 00:00 [revised]
PHST- 2021/01/11 00:00 [accepted]
PHST- 2021/01/21 06:00 [pubmed]
PHST- 2022/03/26 06:00 [medline]
PHST- 2021/01/20 05:42 [entrez]
AID - S1553-8389(21)00013-0 [pii]
AID - 10.1016/j.carrev.2021.01.010 [doi]
PST - ppublish
SO  - Cardiovasc Revasc Med. 2022 Jan;34:86-91. doi: 10.1016/j.carrev.2021.01.010. Epub 
      2021 Jan 14.