PMID- 33470848
OWN - NLM
STAT- MEDLINE
DCOM- 20210524
LR  - 20220202
IS  - 2042-6313 (Electronic)
IS  - 2042-6305 (Print)
IS  - 2042-6305 (Linking)
VI  - 10
IP  - 2
DP  - 2021 Feb
TI  - TELEmedicine as an intervention for sepsis in emergency departments: a 
      multicenter, comparative effectiveness study (TELEvISED Study).
PG  - 77-91
LID - 10.2217/cer-2020-0141 [doi]
AB  - Sepsis is a life-threatening infection that affects over 1.7 million Americans 
      annually. Low-volume rural hospitals have worse sepsis outcomes, and emergency 
      department (ED)-based telemedicine (tele-ED) has been one promising strategy for 
      improving rural sepsis care. The objective of this study is to evaluate the 
      impact of tele-ED consultation on sepsis care and outcomes in rural ED patients. 
      The TELEvISED study is a multicenter (n = 25) retrospective propensity-matched 
      comparative effectiveness study of tele-ED care for rural sepsis patients in a 
      mature tele-ED network. Telemedicine-exposed patients will be matched with non 
      telemedicine patients using a propensity score to predict tele-ED use. The 
      primary outcome is 28-day hospital free days, and secondary outcomes include 
      adherence with guidelines, mortality and organ failure. ClinicalTrials.gov: 
      NCT04441944.
FAU - Mohr, Nicholas M
AU  - Mohr NM
AUID- ORCID: 0000-0003-0497-5828
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa City, IA 52242, USA.
AD  - Division of Critical Care, Department of Anesthesia, University of Iowa Carver 
      College of Medicine, Iowa City, IA 52242, USA.
AD  - Department of Epidemiology, University of Iowa College of Public Health, Iowa 
      City, IA 52242, USA.
FAU - Harland, Karisa K
AU  - Harland KK
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa City, IA 52242, USA.
FAU - Okoro, Uche E
AU  - Okoro UE
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa City, IA 52242, USA.
FAU - Fuller, Brian M
AU  - Fuller BM
AD  - Division of Critical Care, Department of Anesthesiology, Washington University 
      School of Medicine, St. Louis, MO 63110, USA.
AD  - Department of Emergency Medicine, Washington University School of Medicine, St. 
      Louis, MO 63110, USA.
FAU - Campbell, Kalyn
AU  - Campbell K
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa City, IA 52242, USA.
AD  - Department of Surgery, Hennepin County Medical Center, Minneapolis, MN 55415, 
      USA.
FAU - Swanson, Morgan B
AU  - Swanson MB
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa City, IA 52242, USA.
AD  - Department of Epidemiology, University of Iowa College of Public Health, Iowa 
      City, IA 52242, USA.
FAU - Simpson, Stephen Q
AU  - Simpson SQ
AD  - Department of Pulmonary, Critical Care, & Sleep Medicine, University of Kansas, 
      Kansas City, KS 66160, USA.
AD  - Biomedical Advanced Research & Development Authority, US Department of Health & 
      Human Services, Washington, DC 20201, USA.
FAU - Parker, Edith A
AU  - Parker EA
AD  - Department of Community & Behavioral Health, University of Iowa College of Public 
      Health, Iowa City, IA 52242, USA.
FAU - Mack, Luke J
AU  - Mack LJ
AD  - Avera eCARE, Sioux Falls, SD 57104, USA.
AD  - Department of Family Medicine, University of South Dakota School of Medicine, 
      Sioux Falls, SD 57105, USA.
FAU - Bell, Amanda
AU  - Bell A
AD  - Avera eCARE, Sioux Falls, SD 57104, USA.
FAU - DeJong, Katie
AU  - DeJong K
AD  - Avera eCARE, Sioux Falls, SD 57104, USA.
FAU - Faine, Brett
AU  - Faine B
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa City, IA 52242, USA.
AD  - Department of Pharmacy Practice & Science, College of Pharmacy, University of 
      Iowa, Iowa City, IA 52242, USA.
AD  - Department of Pharmaceutical Care, University of Iowa Hospitals & Clinics, 
      Department of Health Management & Policy, Iowa City, IA 52242, USA.
FAU - Zepeski, Anne
AU  - Zepeski A
AD  - Department of Emergency Medicine, University of Iowa Carver College of Medicine, 
      Iowa City, IA 52242, USA.
AD  - Department of Pharmaceutical Care, University of Iowa Hospitals & Clinics, 
      Department of Health Management & Policy, Iowa City, IA 52242, USA.
FAU - Mueller, Keith
AU  - Mueller K
AD  - Department of Health Management and Policy, University of Iowa College of Public 
      Health, Iowa City, IA 52242, USA.
FAU - Chrischilles, Elizabeth
AU  - Chrischilles E
AD  - Department of Epidemiology, University of Iowa College of Public Health, Iowa 
      City, IA 52242, USA.
FAU - Carpenter, Christopher R
AU  - Carpenter CR
AD  - Department of Emergency Medicine, Washington University School of Medicine, St. 
      Louis, MO 63110, USA.
FAU - Jones, Michael P
AU  - Jones MP
AD  - Department of Biostatistics, University of Iowa College of Public Health, Iowa 
      City, IA 52242, USA.
FAU - Ward, Marcia M
AU  - Ward MM
AD  - Department of Health Management and Policy, University of Iowa College of Public 
      Health, Iowa City, IA 52242, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT04441944
GR  - K08 HS025753/HS/AHRQ HHS/United States
GR  - T32 GM007337/GM/NIGMS NIH HHS/United States
GR  - UL1 TR002537/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20210120
PL  - England
TA  - J Comp Eff Res
JT  - Journal of comparative effectiveness research
JID - 101577308
SB  - IM
MH  - *Emergency Medical Services
MH  - Emergency Service, Hospital
MH  - Humans
MH  - Retrospective Studies
MH  - *Sepsis/therapy
MH  - *Telemedicine
PMC - PMC8008221
OTO - NOTNLM
OT  - emergency service
OT  - hospital
OT  - hospitals
OT  - rural
OT  - sepsis
OT  - telemedicine
COIS- Financial & competing interests disclosure This study is supported by the Agency 
      for Healthcare Research and Quality (K08HS025753), the Institute for Clinical and 
      Translational Science at the University of Iowa through a grant from the National 
      Center for Advancing Translational Sciences at the NIH (UL1TR002537), and the 
      Rural Telehealth Research Center through a grant from the Federal Office of Rural 
      Health Policy, Health Resources and Services Administration (U1CRH29074). These 
      contents are solely the responsibility of the authors and do not necessarily 
      reflect the views of the Agency for Healthcare Research and Quality, and National 
      Institutes of Health, or the Federal Office of Rural Health Policy. LJM, AB, and 
      KD declare that they are employed by Avera eCARE, an organization that provides 
      tele-ED services to rural hospitals. The authors have no other relevant 
      affiliations or financial involvement with any organization or entity with a 
      financial interest in or financial conflict with the subject matter or materials 
      discussed in the manuscript apart from those disclosed. No writing assistance was 
      utilized in the production of this manuscript.
EDAT- 2021/01/21 06:00
MHDA- 2021/05/25 06:00
PMCR- 2022/02/01
CRDT- 2021/01/20 12:17
PHST- 2021/01/21 06:00 [pubmed]
PHST- 2021/05/25 06:00 [medline]
PHST- 2021/01/20 12:17 [entrez]
PHST- 2022/02/01 00:00 [pmc-release]
AID - 10.2217/cer-2020-0141 [doi]
PST - ppublish
SO  - J Comp Eff Res. 2021 Feb;10(2):77-91. doi: 10.2217/cer-2020-0141. Epub 2021 Jan 
      20.