PMID- 33472210
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20220531
IS  - 1423-0275 (Electronic)
IS  - 0301-1569 (Linking)
VI  - 83
IP  - 2
DP  - 2021
TI  - The Role of Keratin-8 and Keratin-18 Polymorphisms and Protein Levels in the 
      Occurrence and Progression of Vocal Leukoplakia.
PG  - 65-74
LID - 10.1159/000511447 [doi]
AB  - OBJECTIVE: This study aimed to evaluate the association between the 
      single-nucleotide polymorphism (SNP) and tissue protein level of keratin-8/18 and 
      the occurrence and progression of vocal leukoplakia. METHODS: The case-control 
      study enrolled 158 patients with vocal leukoplakia, 326 patients with laryngeal 
      squamous cell carcinoma (LSCC), and 268 healthy controls, which were tested for 
      genotype analysis with keratin-8 and keratin-18 gene polymorphisms using 
      pyrosequencing. The tissue protein expression levels of keratin-8 and keratin-18 
      were evaluated using immunohistochemistry. RESULTS: The keratin-8 SNP RS1907671 
      showed an obvious increased risk for vocal leukoplakia (OR 1.56, p = 0.002), 
      while the other SNPs (RS2035875, RS2035878, RS4300473) were tested as protective 
      factors for vocal leukoplakia and LSCC (OR <1, p < 0.05). In keratin-18 SNP test, 
      both RS2070876 and RS2638526 polymorphisms demonstrated decreased risks for vocal 
      leukoplakia and LSCC (OR <1, p < 0.05). The protein levels of keratin-8 and 
      keratin-18 in vocal leukoplakia group were significantly higher than those of the 
      LSCC group (p < 0.05). CONCLUSIONS: Keratin-8 and keratin-18 polymorphisms and 
      protein levels are associated with the occurrence and progression of vocal 
      leukoplakia.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Yang, Yue
AU  - Yang Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Eye and ENT Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye and ENT Hospital, 
      Fudan University, Shanghai, China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Otolaryngology-Head and Neck Surgery, Eye and ENT Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye and ENT Hospital, 
      Fudan University, Shanghai, China.
FAU - He, Peijie
AU  - He P
AD  - Department of Otolaryngology-Head and Neck Surgery, Eye and ENT Hospital, Fudan 
      University, Shanghai, China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye and ENT Hospital, 
      Fudan University, Shanghai, China.
FAU - Wu, Haitao
AU  - Wu H
AD  - Department of Otolaryngology-Head and Neck Surgery, Eye and ENT Hospital, Fudan 
      University, Shanghai, China, eentwuhaitao@163.com.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye and ENT Hospital, 
      Fudan University, Shanghai, China, eentwuhaitao@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210120
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
RN  - 0 (Keratin-18)
RN  - 0 (Keratin-8)
SB  - IM
MH  - Carcinoma, Squamous Cell/genetics
MH  - Case-Control Studies
MH  - Head and Neck Neoplasms
MH  - Humans
MH  - Keratin-18/*genetics
MH  - Keratin-8/*genetics
MH  - Laryngeal Neoplasms
MH  - Leukoplakia/*genetics
MH  - Vocal Cords
OTO - NOTNLM
OT  - Keratin-18
OT  - Keratin-8
OT  - Polymorphism
OT  - Protein level
OT  - Vocal leukoplakia
EDAT- 2021/01/21 06:00
MHDA- 2021/05/21 06:00
CRDT- 2021/01/20 20:08
PHST- 2020/02/05 00:00 [received]
PHST- 2020/09/08 00:00 [accepted]
PHST- 2021/01/21 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2021/01/20 20:08 [entrez]
AID - 000511447 [pii]
AID - 10.1159/000511447 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 2021;83(2):65-74. doi: 10.1159/000511447. Epub 
      2021 Jan 20.