PMID- 33472995
OWN - NLM
STAT- MEDLINE
DCOM- 20210122
LR  - 20210122
IS  - 1672-7347 (Print)
IS  - 1672-7347 (Linking)
VI  - 45
IP  - 12
DP  - 2020 Dec 28
TI  - Risk factors of early mortality after surgical treatment for infective 
      endocarditis.
PG  - 1403-1411
LID - 1672-7347(2020)12-1403-09 [pii]
LID - 10.11817/j.issn.1672-7347.2020.190667 [doi]
AB  - OBJECTIVES: To explore the basic clinical characteristics and relevant factors 
      affecting the early postoperative prognosis in patients with infective 
      endocarditis (IE). METHODS: A total of 702 patients with IE, who underwent 
      surgery in Xiangya Hospital, Central South University from January 1981 to June 
      2019, were studied and the data were collected through the paper records and the 
      hospital information system. The patients from January 1981 to June 2010 served 
      as an early group (n=224), and other patients from July 2010 to June 2019 served 
      as a recent group (n=478). Independent risk factors for early postoperative death 
      were determined by logistic regression analysis. RESULTS: The mean age of the 702 
      patients was 36.7+/-16.1 years, and the male accounted for 68.1%. Preoperative 
      stroke occurred in 71 patients (10.1%), and dialysis was done in 14 patients (2%) 
      preoperatively. Streptococcus were the pathogenic bacteria in 172 patients, 
      accounting for 59.5% of all positive blood culture results. In the early group, 
      the percentage of IE combined with congenital heart disease was significantly 
      higher than that in the recent group [77 patients (34.4%) in the early group vs 
      22 patients (4.6%) in the recent group; P<0.05]. Postoperative stroke occurred in 
      15 patients (2.1%), while 59 patients (7%) required new dialysis postoperatively 
      because of renal insufficiency. Twenty-nine patient died in the post-operation, 
      with 4.1% in 30-day mortality. Logistic regression analysis revealed that the 
      high preoperative New York Heart Association (NYHA) grade of cardiac function 
      (OR=3.22, 95% CI 1.50-6.88; P<0.01), postoperative stroke (OR=5.75, 95% CI 
      1.22-27.07; P<0.05), postoperative dialysis (OR=15.53, 95% CI 3.50-68.82; 
      P<0.01), perivalvular abscess (OR=13.19, 95% CI 3.83-45.42; P<0.01) and 
      multivalve involvement (OR=3.57, 95% CI 1.24-10.30; P<0.05) were the independent 
      risk factors for early mortality. CONCLUSIONS: Streptococcus is the most common 
      pathogenic bacteria in the patients with IE. Surgery for IE can obtain a 
      satisfactory early outcomes. High preoperative NYHA grade of cardiac function, 
      postoperative stroke, postoperative dialysis, perivalvular abscess and multivalve 
      involvement are the independent risk factors for early mortality.
FAU - Ling, Youpeng
AU  - Ling Y
AD  - Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, 
      Changsha 410008, China. lingyoupeng@csu.edu.cn.
FAU - Chen, Xuliang
AU  - Chen X
AD  - Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, 
      Changsha 410008, China.
FAU - Chen, Yingji
AU  - Chen Y
AD  - Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, 
      Changsha 410008, China.
FAU - Sa, Mi
AU  - Sa M
AD  - Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, 
      Changsha 410008, China.
FAU - Luo, Wangjun
AU  - Luo W
AD  - Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, 
      Changsha 410008, China. luo3478@aliyun.com.
LA  - eng
LA  - chi
PT  - Journal Article
TT  - 感染性心内膜炎患者术后早期死亡的危险因素.
PL  - China
TA  - Zhong Nan Da Xue Xue Bao Yi Xue Ban
JT  - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. 
      Medical sciences
JID - 101230586
SB  - IM
MH  - Adult
MH  - *Endocarditis/surgery
MH  - *Endocarditis, Bacterial/surgery
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
OTO - NOTNLM
OT  - cardiac surgery
OT  - early mortality
OT  - infective endocarditis
OT  - risk factors
EDAT- 2021/01/22 06:00
MHDA- 2021/01/23 06:00
CRDT- 2021/01/21 05:28
PHST- 2021/01/21 05:28 [entrez]
PHST- 2021/01/22 06:00 [pubmed]
PHST- 2021/01/23 06:00 [medline]
AID - 1672-7347(2020)12-1403-09 [pii]
AID - 10.11817/j.issn.1672-7347.2020.190667 [doi]
PST - ppublish
SO  - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Dec 28;45(12):1403-1411. doi: 
      10.11817/j.issn.1672-7347.2020.190667.