PMID- 33473021
OWN - NLM
STAT- MEDLINE
DCOM- 20210122
LR  - 20220531
IS  - 1119-3077 (Print)
VI  - 24
IP  - 1
DP  - 2021 Jan
TI  - Iron Deficiency Anemia in Nigerians with Heart Failure (IDAN-HF): Therapeutic 
      efficacy of iron replacement: An interventional study.
PG  - 21-27
LID - 10.4103/njcp.njcp_387_19 [doi]
AB  - BACKGROUND: Recent evidence has reported significant improvement in clinical 
      profile, quality of life, and prognosis of heart failure subjects with iron 
      replacement. AIMS: This study aimed to determine the safety and outcome of 
      parenteral iron replacement among heart failure subjects in Nigeria. METHOD: A 
      randomized interventional study was done at the Cardiology Clinic of LAUTECH 
      Teaching Hospital, Ogbomoso, Nigeria. One hundred and forty subjects with heart 
      failure were recruited. Iron deficiency and anemia were determined according to 
      standardized criteria. Parenteral iron dextran was administered to a block 
      randomized group of 30 of those identified with iron deficiency and compared with 
      controls. The primary outcome was the six minutes' walk test (6 MWT) after 8 
      weeks while the Kansas City Cardiomyopathy Questionnaire (KCCQ) score was used to 
      assess the quality of life as a secondary outcome. Statistical analysis was done 
      with the SPSS 20.0. P value <0.05 was taken as statistically significant. 
      RESULTS: Iron deficiency was present in 84 (60.0%) of all study participants. 
      Iron dextran was fairly tolerated with mild to moderate adverse reactions 
      reported in 7 (23.3%) subjects who had an iron infusion. Improvement in the 6 MWT 
      distance (390.1 +/- 92.6 vs. 156.9 +/- 72.5 meters, P < 0.05) and the KCCQ score 
      (84.5 +/- 3.7 vs. 64.2 +/- 12.5%, P < 0.05) among iron-deficient heart failure 
      subjects who received iron dextran was significantly higher than those who did 
      not receive the iron replacement. Functional classification according to the New 
      York Heart Association (NYHA) profile and heart rate were also much improved 
      after the iron replacement than those who did not receive it. CONCLUSION: 
      Parenteral iron dextran therapy was fairly tolerated among heart failure 
      subjects. Iron replacement is associated with improved quality of life, better 
      temporal clinical profile, and functional classification among Nigerians with 
      heart failure. Iron replacement therapy can be an additional therapeutic option 
      in heart failure management among Africans to improve prognosis.
FAU - Akintunde, A A
AU  - Akintunde AA
AD  - Department of Medicine, Cardiology Unit, Ladoke Akintola University of Technology 
      (LAUTECH) Teaching Hospital, Ogbomoso; Department of Medicine, Faculty of 
      Clinical Sciences, College of Health Sciences, LAUTECH, Osogbo, Nigeria.
FAU - Akinlade, O M
AU  - Akinlade OM
AD  - Department of Medicine, Cardiology Unit, Ladoke Akintola University of Technology 
      (LAUTECH) Teaching Hospital, Ogbomoso, Nigeria.
FAU - Egbewale, B E
AU  - Egbewale BE
AD  - Department of Community Medicine, Faculty of Clinical Sciences, Ladoke Akintola 
      University of Technology, Osogbo, Nigeria.
FAU - Opadijo, O G
AU  - Opadijo OG
AD  - Department of Medicine, Cardiology Unit, Ladoke Akintola University of Technology 
      (LAUTECH) Teaching Hospital, Ogbomoso; Department of Medicine, Faculty of 
      Clinical Sciences, College of Health Sciences, LAUTECH, Osogbo, Nigeria.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - India
TA  - Niger J Clin Pract
JT  - Nigerian journal of clinical practice
JID - 101150032
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - *Anemia, Iron-Deficiency/drug therapy
MH  - *Heart Failure/complications/drug therapy
MH  - Humans
MH  - *Iron/therapeutic use
MH  - Nigeria
MH  - Quality of Life
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Heart failure
OT  - Nigeria
OT  - iron deficiency anemia
OT  - parenteral iron replacement
COIS- None
EDAT- 2021/01/22 06:00
MHDA- 2021/01/23 06:00
CRDT- 2021/01/21 05:28
PHST- 2021/01/21 05:28 [entrez]
PHST- 2021/01/22 06:00 [pubmed]
PHST- 2021/01/23 06:00 [medline]
AID - NigerJClinPract_2021_24_1_21_307493 [pii]
AID - 10.4103/njcp.njcp_387_19 [doi]
PST - ppublish
SO  - Niger J Clin Pract. 2021 Jan;24(1):21-27. doi: 10.4103/njcp.njcp_387_19.