PMID- 33474513
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230106
IS  - 2452-199X (Electronic)
IS  - 2452-199X (Linking)
VI  - 6
IP  - 7
DP  - 2021 Jul
TI  - Injectable silk sericin scaffolds with programmable shape-memory property and 
      neuro-differentiation-promoting activity for individualized brain repair of 
      severe ischemic stroke.
PG  - 1988-1999
LID - 10.1016/j.bioactmat.2020.12.017 [doi]
AB  - Severe ischemic stroke damages neuronal tissue, forming irregular-shaped stroke 
      cavities devoid of supporting structure. Implanting biomaterials to provide 
      structural and functional support is thought to favor ingrowth of regenerated 
      neuronal networks. Injectable hydrogels capable of in situ gelation are often 
      utilized for stroke repair, but challenged by incomplete gelation and imprecise 
      control over end-macrostructure. Injectable shape-memory scaffolds might overcome 
      these limitations, but are not explored for stroke repair. Here, we report an 
      injectable, photoluminescent, carbon-nanotubes-doped sericin scaffold (CNTs-SS) 
      with programmable shape-memory property. By adjusting CNTs' concentrations, 
      CNTs-SS' recovery dynamics can be mathematically calculated at the scale of 
      seconds, and its shapes can be pre-designed to precisely match any 
      irregular-shaped cavities. Using a preclinical stroke model, we show that CNTs-SS 
      with the customized shape is successfully injected into the cavity and recovers 
      its pre-designed shape to well fit the cavity. Notably, CNTs-SS' near-infrared 
      photoluminescence enables non-invasive, real-time tracking after in vivo 
      implantation. Moreover, as a cell carrier, CNTs-SS not only deliver bone marrow 
      mesenchymal stem cells (BMSCs) into brain tissues, but also functionally promote 
      their neuronal differentiation. Together, we for the first time demonstrate the 
      feasibility of applying injectable shape-memory scaffolds for stroke repair, 
      paving the way for personalized stroke repair.
CI  - (c) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of KeAi 
      Communications Co., Ltd.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of Clinical Laboratory, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430022, China.
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
FAU - Li, Xiaolin
AU  - Li X
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
FAU - Song, Yu
AU  - Song Y
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
FAU - Su, Qiangfei
AU  - Su Q
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
FAU - Xiaohalati, Xiakeerzhati
AU  - Xiaohalati X
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
FAU - Yang, Wen
AU  - Yang W
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
FAU - Xu, Luming
AU  - Xu L
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
FAU - Cai, Bo
AU  - Cai B
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
FAU - Wang, Guobin
AU  - Wang G
AD  - Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430022, China.
FAU - Wang, Zheng
AU  - Wang Z
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
AD  - Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430022, China.
FAU - Wang, Lin
AU  - Wang L
AD  - Department of Clinical Laboratory, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, 430022, China.
AD  - Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, 
      Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 
      430022, China.
LA  - eng
PT  - Journal Article
DEP - 20201229
PL  - China
TA  - Bioact Mater
JT  - Bioactive materials
JID - 101685294
PMC - PMC7786039
OTO - NOTNLM
OT  - Injectability
OT  - Neuronal differentiation
OT  - Shape-memory properties
OT  - Silk sericin scaffolds
OT  - Stroke cavities
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/22 06:00
MHDA- 2021/01/22 06:01
PMCR- 2020/12/29
CRDT- 2021/01/21 05:37
PHST- 2020/10/28 00:00 [received]
PHST- 2020/12/12 00:00 [revised]
PHST- 2020/12/20 00:00 [accepted]
PHST- 2021/01/21 05:37 [entrez]
PHST- 2021/01/22 06:00 [pubmed]
PHST- 2021/01/22 06:01 [medline]
PHST- 2020/12/29 00:00 [pmc-release]
AID - S2452-199X(20)30343-1 [pii]
AID - 10.1016/j.bioactmat.2020.12.017 [doi]
PST - epublish
SO  - Bioact Mater. 2020 Dec 29;6(7):1988-1999. doi: 10.1016/j.bioactmat.2020.12.017. 
      eCollection 2021 Jul.