PMID- 33474924
OWN - NLM
STAT- MEDLINE
DCOM- 20210122
LR  - 20210122
IS  - 0042-4668 (Print)
IS  - 0042-4668 (Linking)
VI  - 85
IP  - 6
DP  - 2020
TI  - [Topical drugs for the treatment of non-streptococcal acute tonsillopharyngitis 
      in children: results of a multicenter study].
PG  - 84-89
LID - 10.17116/otorino20208506184 [doi]
AB  - INTRODUCTION: Acute tonsillopharyngitis (ATP) is a very common disease in 
      children. In non-streptococcal ATP, systemic antibiotics are usually not 
      indicated, but topical antimicrobial therapy is advisable. OBJECTIVE: To evaluate 
      the effectiveness of the combination of cetylpyridinium chloride with gramicidin 
      C in the form of a spray in children with ATP in a prospective multicenter 
      non-interventional study. Patients and methods. The study included 94 patients 
      aged 6-15 years with non-streptococcal ATP. A standard examination, assessment of 
      the pain intensity in the throat using a visual analogue scale, assessment of the 
      pain frequency during swallowing and a score assessment of objective 
      manifestations were carried out. Sixty-eight patients of the main group received 
      a combination of cetylpyridinium chloride with gramicidin C (Grammidin for 
      children) in the form of a spray, 26 patients of the control group received 
      throat irrigation with saline solution (based on sea water) for 7 days. Therapy 
      was assessed after 1 day (by phone), 4 and 8 days (by examination). RESULTS: The 
      groups of patients did not differ significantly in terms of demographic 
      indicators and initial clinical manifestations. Body temperature initially did 
      not differ, but was significantly lower in the main group after 1 (p=0.003) and 4 
      (p=0.04) days. The sore throat pain intensity decrease in the main group 
      significantly exceeded this indicator in the control group after 1 (p<0.001) and 
      4 (p <0.001) days. Initially, swallowing pain was observed in all patients, after 
      4 days the complaint was significantly less frequent in the main group (p<0.001). 
      The total assessment of objective data was significantly lower in the main group 
      after 4 (p<0.001) and 8 (p<0.001) days. No adverse effects of pharmacotherapy 
      were observed. CONCLUSIONS: The study showed high efficacy and safety of the 
      cetylpyridinium chloride and gramicidin C (in the form of a spray) combination 
      for non-streptococcal ATP in children aged 6-15 years.
FAU - Geppe, N A
AU  - Geppe NA
AUID- ORCID: 0000-0003-0547-3686
AD  - All-Russian public organization <<Pediatric Respiratory Society>>, Kolomna, Russia.
AD  - N.F. Filatov Clinical Institute of Children's Health of the I.M. Sechenov First 
      Moscow State Medical University (Sechenov University), Moscow, Russia.
FAU - Karpova, E P
AU  - Karpova EP
AUID- ORCID: 0000-0002-8292-9635
AD  - All-Russian public organization <<Pediatric Respiratory Society>>, Kolomna, Russia.
AD  - Russian Medical Academy of Continuing Professional Education, Moscow, Russia.
FAU - Dronov, I A
AU  - Dronov IA
AUID- ORCID: 0000-0002-6304-0355
AD  - All-Russian public organization <<Pediatric Respiratory Society>>, Kolomna, Russia.
AD  - N.F. Filatov Clinical Institute of Children's Health of the I.M. Sechenov First 
      Moscow State Medical University (Sechenov University), Moscow, Russia.
FAU - Kovalenko, E A
AU  - Kovalenko EA
AD  - All-Russian public organization <<Pediatric Respiratory Society>>, Kolomna, Russia.
AD  - Tver State Medical University, Tver, Russia.
FAU - Botneva, A V
AU  - Botneva AV
AD  - All-Russian public organization <<Pediatric Respiratory Society>>, Kolomna, Russia.
AD  - Medical centers <<New medical technologies network>>, Ramenskoye, Russia.
FAU - Terent'ev, V A
AU  - Terent'ev VA
AD  - All-Russian public organization <<Pediatric Respiratory Society>>, Kolomna, Russia.
AD  - Municipal Infectious Diseases Hospital, Sevastopol, Russia.
FAU - Velikoreckaya, M D
AU  - Velikoreckaya MD
AUID- ORCID: 0000-0001-6592-0121
AD  - All-Russian public organization <<Pediatric Respiratory Society>>, Kolomna, Russia.
AD  - N.F. Filatov Clinical Institute of Children's Health of the I.M. Sechenov First 
      Moscow State Medical University (Sechenov University), Moscow, Russia.
FAU - Kolosova, N G
AU  - Kolosova NG
AUID- ORCID: 0000-0001-5071-9302
AD  - All-Russian public organization <<Pediatric Respiratory Society>>, Kolomna, Russia.
AD  - N.F. Filatov Clinical Institute of Children's Health of the I.M. Sechenov First 
      Moscow State Medical University (Sechenov University), Moscow, Russia.
LA  - rus
PT  - Journal Article
PT  - Multicenter Study
TT  - Topicheskie preparaty dlya lecheniya nestreptokokkovogo ostrogo tonzillofaringita 
      u detei: rezul'taty mnogotsentrovogo issledovaniya.
PL  - Russia (Federation)
TA  - Vestn Otorinolaringol
JT  - Vestnik otorinolaringologii
JID - 0416577
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Adolescent
MH  - Anti-Bacterial Agents
MH  - Child
MH  - Humans
MH  - *Pharmaceutical Preparations
MH  - *Pharyngitis/diagnosis/drug therapy
MH  - Prospective Studies
MH  - *Streptococcal Infections
MH  - Streptococcus pyogenes
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Grammidin
OT  - acute tonsillopharyngitis
OT  - cetylpyridinium chloride
OT  - children
OT  - gramicidin C
OT  - topical therapy
EDAT- 2021/01/22 06:00
MHDA- 2021/01/23 06:00
CRDT- 2021/01/21 07:49
PHST- 2021/01/21 07:49 [entrez]
PHST- 2021/01/22 06:00 [pubmed]
PHST- 2021/01/23 06:00 [medline]
AID - 10.17116/otorino20208506184 [doi]
PST - ppublish
SO  - Vestn Otorinolaringol. 2020;85(6):84-89. doi: 10.17116/otorino20208506184.