PMID- 33475936 OWN - NLM STAT- MEDLINE DCOM- 20211109 LR - 20211109 IS - 1573-3602 (Electronic) IS - 1050-5350 (Linking) VI - 37 IP - 4 DP - 2021 Dec TI - Are Comorbid Disorders Associated with Changes in Gambling Activity? A Longitudinal Study of Younger and Older Subjects with DSM-IV Pathological Gambling. PG - 1219-1230 LID - 10.1007/s10899-021-10000-x [doi] AB - This study investigates the association of comorbid disorders with gambling activity in a longitudinal follow-up study of younger and older adult subjects with DSM-IV pathological gambling (PG). The subjects included 57 younger adults with PG (>/= 18/ < 40 years) and 48 older adults with PG (>/= 60 years). Subjects were assessed at baseline and every 6 months for a mean (SD) of 31.4 (13.1) months. Comorbidity was assessed using a modification of the Longitudinal Interval Follow-up Evaluation (LIFE). During follow-up, rates of problem severity were highest for anxiety disorders, mood disorders, and impulse control disorders. Among all subjects with PG, greater severity of depression or posttraumatic stress disorder was associated with increased gambling activity. In older subjects, greater severity of agoraphobia and social phobia were associated with lowered gambling activity. In younger subjects, greater severity of any substance use disorder, an alcohol use disorder, or compulsive computer use were associated with lowered gambling activity. The latter findings provide presumptive evidence for the substitute addiction hypothesis. We conclude that increased severity of several comorbid disorders could serve as triggers for increased gambling or predict lowered gambling activity. On the other hand, certain comorbid disorders could be triggered by increased gambling activity. Knowing these interrelationships is important to gaining a better understanding of PG and its clinical management. CI - (c) 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. FAU - Black, Donald W AU - Black DW AD - Department of Psychiatry, University of Iowa Carver College of Medicine, 2-126bMEB/Psychiatry Research, Iowa City, IA, 52242, USA. donald-black@uiowa.edu. FAU - Allen, Jeff AU - Allen J AD - Department of Psychiatry, University of Iowa Carver College of Medicine, 2-126bMEB/Psychiatry Research, Iowa City, IA, 52242, USA. FAU - Bormann, Nicolas L AU - Bormann NL AD - University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA. LA - eng GR - RO1AG037132/AG/NIA NIH HHS/United States GR - RO1AG037132/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20210121 PL - United States TA - J Gambl Stud JT - Journal of gambling studies JID - 9425991 SB - IM MH - Aged MH - *Behavior, Addictive/epidemiology MH - Diagnostic and Statistical Manual of Mental Disorders MH - Follow-Up Studies MH - *Gambling/psychology MH - Humans MH - Longitudinal Studies OTO - NOTNLM OT - Addictions OT - Comorbidity OT - Follow-up study OT - Gambling disorder OT - Pathological gambling OT - Substitute addiction EDAT- 2021/01/22 06:00 MHDA- 2021/11/10 06:00 CRDT- 2021/01/21 12:21 PHST- 2021/01/05 00:00 [accepted] PHST- 2021/01/22 06:00 [pubmed] PHST- 2021/11/10 06:00 [medline] PHST- 2021/01/21 12:21 [entrez] AID - 10.1007/s10899-021-10000-x [pii] AID - 10.1007/s10899-021-10000-x [doi] PST - ppublish SO - J Gambl Stud. 2021 Dec;37(4):1219-1230. doi: 10.1007/s10899-021-10000-x. Epub 2021 Jan 21.