PMID- 33476954
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 200
DP  - 2021 Apr
TI  - Facile preparation of pH/redox dual-responsive biodegradable polyphosphazene 
      prodrugs for effective cancer chemotherapy.
PG  - 111573
LID - S0927-7765(21)00017-5 [pii]
LID - 10.1016/j.colsurfb.2021.111573 [doi]
AB  - In order to maximize the therapeutic effect and and minimize the systemtic side 
      effect of the small molecule anticancer drugs, biodegradable drug delivery 
      systems (DDSs) that respond to tumor microenvironment (TME) have attracted 
      significant attention. Herein, a novel redox/pH dual-responsive and biodegradable 
      polyphosphazene (PPZ) nano-prodrugs have been prepared via one-pot crosslinking 
      of vanillin modified DOX (VMD, acid-sensitive) and 4,4'-dihydroxydiphenyl 
      disulfide (HPS, GSH-responsive) with hexachlorocyclotriphosphazene (HCCP). The 
      phenol groups of the as-synthesized VMD and HPS have high nucleophilic 
      substitution activity towards HCCP under base catalyst and afforded PPZ 
      nano-prodrugs, denoted as HCCP-VMD-HPS, with a high drug loading ratio of up to 
      56.4 %. As expected, the skeleton of the PPZ consisting of imine bonds in VMD and 
      the disulfide bonds in HPS and cyclotriphosphazenes inclined to be decomposed in 
      low pH conditions and high level of GSH environments. The antitumor drug DOX was 
      found to be controlled released in TME conditions (extracellular, pH approximately 6.8 and 
      endosomes, lysosomes pH approximately 5.0 with  approximately 10 mM GSH), rather than neutral physiological 
      conditions (pH 7.4 with  approximately 20 muM GSH). Moreover, the resulting HCCP-VMD-HPS 
      nano-prodrug have obvious cytotoxicity to cancer cells while a negligible side 
      effect to normal cells. We therefore believe that the prepared redox/pH 
      dual-responsive and biodegradable PPZ DDSs have great potential in various field.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Wang, Daquan
AU  - Wang D
AD  - School of Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and 
      Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an, 710049, China.
FAU - Zhou, Na
AU  - Zhou N
AD  - Key Laboratory of Thermo-Fluid Science and Engineering of MOE, School of Energy 
      and Power Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, China.
FAU - Zhang, Ning
AU  - Zhang N
AD  - School of Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and 
      Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an, 710049, China.
FAU - Zhi, Zhe
AU  - Zhi Z
AD  - Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 
      710049, China.
FAU - Shao, Yongping
AU  - Shao Y
AD  - Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 
      710049, China.
FAU - Meng, Lingjie
AU  - Meng L
AD  - School of Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and 
      Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an, 710049, China; 
      Instrumental Analysis Center, Xi'an Jiaotong University, Xi'an, 710049, China. 
      Electronic address: menglingjie@mail.xjtu.edu.cn.
FAU - Yu, Demei
AU  - Yu D
AD  - School of Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and 
      Modulation of Condensed Matter, Xi'an Jiaotong University, Xi'an, 710049, China. 
      Electronic address: dmyu@xjtu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210112
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Polymers)
RN  - 0 (Prodrugs)
RN  - 0 (poly(phosphazene))
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Doxorubicin/pharmacology
MH  - Drug Delivery Systems
MH  - Hydrogen-Ion Concentration
MH  - *Neoplasms
MH  - Organophosphorus Compounds
MH  - Oxidation-Reduction
MH  - Polymers
MH  - *Prodrugs
OTO - NOTNLM
OT  - Chemotherapy
OT  - Drug delivery system
OT  - Polyphosphazene
OT  - Prodrugs
OT  - Redox/pH responsive
EDAT- 2021/01/22 06:00
MHDA- 2021/06/22 06:00
CRDT- 2021/01/21 20:15
PHST- 2020/12/04 00:00 [received]
PHST- 2021/01/06 00:00 [revised]
PHST- 2021/01/07 00:00 [accepted]
PHST- 2021/01/22 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2021/01/21 20:15 [entrez]
AID - S0927-7765(21)00017-5 [pii]
AID - 10.1016/j.colsurfb.2021.111573 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2021 Apr;200:111573. doi: 
      10.1016/j.colsurfb.2021.111573. Epub 2021 Jan 12.