PMID- 33477434
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210218
IS  - 2076-3425 (Print)
IS  - 2076-3425 (Electronic)
IS  - 2076-3425 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 18
TI  - Modulation of Motor Cortex Plasticity by Repetitive Paired-Pulse TMS at Late 
      I-Wave Intervals Is Influenced by Intracortical Excitability.
LID - 10.3390/brainsci11010121 [doi]
LID - 121
AB  - The late indirect (I)-waves recruited by transcranial magnetic stimulation (TMS) 
      over primary motor cortex (M1) can be modulated using I-wave periodicity 
      repetitive TMS (iTMS). The purpose of this study was to determine if the response 
      to iTMS is influenced by different interstimulus intervals (ISIs) targeting late 
      I-waves, and whether these responses were associated with individual variations 
      in intracortical excitability. Seventeen young (27.2 +/- 6.4 years, 12 females) 
      healthy adults received iTMS at late I-wave intervals (4.0, 4.5, and 5.0 ms) in 
      three separate sessions. Changes due to each intervention were examined with 
      motor evoked potential (MEP) amplitudes and short-interval intracortical 
      facilitation (SICF) using both posterior-anterior (PA) and anterior-posterior 
      (AP) TMS current directions. Changes in MEP amplitude and SICF were influenced by 
      iTMS ISI, with the greatest facilitation for ISIs at 4 and 5 ms with PA TMS, and 
      4 ms with AP TMS. Maximum SICF at baseline (irrespective of ISI) was associated 
      with increased iTMS response, but only for PA stimulation. These results suggest 
      that modifying iTMS parameters targeting late I-waves can influence M1 
      plasticity. They also suggest that maximum SICF may be a means by which 
      responders to iTMS targeting the late I-waves could be identified.
FAU - Opie, George M
AU  - Opie GM
AD  - Discipline of Physiology, Adelaide Medical School, The University of Adelaide, 
      Adelaide 5005, Australia.
FAU - Sasaki, Ryoki
AU  - Sasaki R
AD  - Discipline of Physiology, Adelaide Medical School, The University of Adelaide, 
      Adelaide 5005, Australia.
FAU - Hand, Brodie J
AU  - Hand BJ
AD  - Discipline of Physiology, Adelaide Medical School, The University of Adelaide, 
      Adelaide 5005, Australia.
FAU - Semmler, John G
AU  - Semmler JG
AUID- ORCID: 0000-0003-0260-8047
AD  - Discipline of Physiology, Adelaide Medical School, The University of Adelaide, 
      Adelaide 5005, Australia.
LA  - eng
GR  - DP200101009/Australian Research Council/
GR  - 1139723/National Health and Medical Research Council/
GR  - 201830079/Uehara Memorial Foundation/
PT  - Journal Article
DEP - 20210118
PL  - Switzerland
TA  - Brain Sci
JT  - Brain sciences
JID - 101598646
PMC - PMC7829868
OTO - NOTNLM
OT  - I-wave periodicity repetitive TMS
OT  - ageing
OT  - corticospinal descending volley
OT  - motor cortex
OT  - short-interval intracortical facilitation
OT  - transcranial magnetic stimulation
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/23 06:00
MHDA- 2021/01/23 06:01
PMCR- 2021/01/18
CRDT- 2021/01/22 01:02
PHST- 2020/12/04 00:00 [received]
PHST- 2021/01/13 00:00 [revised]
PHST- 2021/01/15 00:00 [accepted]
PHST- 2021/01/22 01:02 [entrez]
PHST- 2021/01/23 06:00 [pubmed]
PHST- 2021/01/23 06:01 [medline]
PHST- 2021/01/18 00:00 [pmc-release]
AID - brainsci11010121 [pii]
AID - brainsci-11-00121 [pii]
AID - 10.3390/brainsci11010121 [doi]
PST - epublish
SO  - Brain Sci. 2021 Jan 18;11(1):121. doi: 10.3390/brainsci11010121.