PMID- 33477581
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210218
IS  - 2075-1729 (Print)
IS  - 2075-1729 (Electronic)
IS  - 2075-1729 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 18
TI  - Systemic Inflammation Associated with Immune Reconstitution Inflammatory Syndrome 
      in Persons Living with HIV.
LID - 10.3390/life11010065 [doi]
LID - 65
AB  - Antiretroviral therapy (ART) has represented a major advancement in the care of 
      people living with HIV (PLWHH), resulting in significant reductions in morbidity 
      and mortality through immune reconstitution and attenuation of homeostatic 
      disruption. Importantly, restoration of immune function in PLWH with 
      opportunistic infections occasionally leads to an intense and uncontrolled 
      cytokine storm following ART initiation known as immune reconstitution 
      inflammatory syndrome (IRIS). IRIS occurrence is associated with the severe and 
      rapid clinical deterioration that results in significant morbidity and mortality. 
      Here, we detail the determinants underlying IRIS development in PLWH, compiling 
      the available knowledge in the field to highlight details of the inflammatory 
      responses in IRIS associated with the most commonly reported opportunistic 
      pathogens. This review also highlights gaps in the understanding of IRIS 
      pathogenesis and summarizes therapeutic strategies that have been used for IRIS.
FAU - Vinhaes, Caian L
AU  - Vinhaes CL
AD  - Instituto Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador 40296-710, Brazil.
AD  - Multinational Organization Network Sponsoring Translational and Epidemiological 
      Research (MONSTER) Initiative, Salvador 40210-320, Brazil.
AD  - Bahiana School of Medicine and Public Health, Bahia Foundation for the 
      Development of Sciences, Salvador 40290-000, Brazil.
FAU - Araujo-Pereira, Mariana
AU  - Araujo-Pereira M
AD  - Instituto Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador 40296-710, Brazil.
AD  - Multinational Organization Network Sponsoring Translational and Epidemiological 
      Research (MONSTER) Initiative, Salvador 40210-320, Brazil.
AD  - Faculdade de Medicina, Universidade Federal da Bahia, Salvador 40110-100, Brazil.
FAU - Tiburcio, Rafael
AU  - Tiburcio R
AD  - Instituto Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador 40296-710, Brazil.
AD  - Multinational Organization Network Sponsoring Translational and Epidemiological 
      Research (MONSTER) Initiative, Salvador 40210-320, Brazil.
AD  - Faculdade de Medicina, Universidade Federal da Bahia, Salvador 40110-100, Brazil.
FAU - Cubillos-Angulo, Juan M
AU  - Cubillos-Angulo JM
AUID- ORCID: 0000-0002-3877-5077
AD  - Instituto Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador 40296-710, Brazil.
AD  - Multinational Organization Network Sponsoring Translational and Epidemiological 
      Research (MONSTER) Initiative, Salvador 40210-320, Brazil.
AD  - Faculdade de Medicina, Universidade Federal da Bahia, Salvador 40110-100, Brazil.
FAU - Demitto, Fernanda O
AU  - Demitto FO
AD  - Multinational Organization Network Sponsoring Translational and Epidemiological 
      Research (MONSTER) Initiative, Salvador 40210-320, Brazil.
FAU - Akrami, Kevan M
AU  - Akrami KM
AD  - Instituto Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador 40296-710, Brazil.
AD  - Multinational Organization Network Sponsoring Translational and Epidemiological 
      Research (MONSTER) Initiative, Salvador 40210-320, Brazil.
AD  - Faculdade de Medicina, Universidade Federal da Bahia, Salvador 40110-100, Brazil.
AD  - Divisions of Infectious Diseases and Pulmonary, Critical Care and Sleep Medicine, 
      Department of Medicine, University of California, San Diego, CA 92093, USA.
FAU - Andrade, Bruno B
AU  - Andrade BB
AUID- ORCID: 0000-0001-6833-3811
AD  - Instituto Goncalo Moniz, Fundacao Oswaldo Cruz, Salvador 40296-710, Brazil.
AD  - Multinational Organization Network Sponsoring Translational and Epidemiological 
      Research (MONSTER) Initiative, Salvador 40210-320, Brazil.
AD  - Bahiana School of Medicine and Public Health, Bahia Foundation for the 
      Development of Sciences, Salvador 40290-000, Brazil.
AD  - Faculdade de Medicina, Universidade Federal da Bahia, Salvador 40110-100, Brazil.
AD  - Curso de Medicina, Centro Universitario Faculdade de Tecnologia e Ciencias 
      (UniFTC), Salvador 41741-590, Brazil.
LA  - eng
GR  - U01-AI115940/National Institute of Allergy and Infectious Diseases/
GR  - PhD fellowship (finance code 001)/Coordenacao de Aperfeicoamento de Pessoal de 
      Nivel Superior/
GR  - Research fellowship/Conselho Nacional de Desenvolvimento Cientifico e 
      Tecnologico/
GR  - Research Fellowship/MONSTER Initiative/
GR  - Intramural Research Program/Fundacao Oswaldo Cruz/
PT  - Journal Article
PT  - Review
DEP - 20210118
PL  - Switzerland
TA  - Life (Basel)
JT  - Life (Basel, Switzerland)
JID - 101580444
PMC - PMC7831327
OTO - NOTNLM
OT  - HIV
OT  - immune reconstitution inflammatory syndrome (IRIS)
OT  - mycobacteria
OT  - systemic inflammation
COIS- The authors declare no conflict of interest.
EDAT- 2021/01/23 06:00
MHDA- 2021/01/23 06:01
PMCR- 2021/01/18
CRDT- 2021/01/22 01:02
PHST- 2020/11/16 00:00 [received]
PHST- 2021/01/13 00:00 [revised]
PHST- 2021/01/14 00:00 [accepted]
PHST- 2021/01/22 01:02 [entrez]
PHST- 2021/01/23 06:00 [pubmed]
PHST- 2021/01/23 06:01 [medline]
PHST- 2021/01/18 00:00 [pmc-release]
AID - life11010065 [pii]
AID - life-11-00065 [pii]
AID - 10.3390/life11010065 [doi]
PST - epublish
SO  - Life (Basel). 2021 Jan 18;11(1):65. doi: 10.3390/life11010065.