PMID- 33478286
OWN - NLM
STAT- MEDLINE
DCOM- 20211217
LR  - 20211217
IS  - 1532-432X (Electronic)
IS  - 0363-0269 (Linking)
VI  - 45
IP  - 1
DP  - 2021 Jan
TI  - Comparison of Hematopoietic Stem Cell Transplantation Results in Patients with 
      beta-Thalassemia Major from Three Different Graft Types.
PG  - 25-29
LID - 10.1080/03630269.2021.1872611 [doi]
AB  - Allogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy 
      for beta-thalassemias that induces severe life-threatening complications. The human 
      leukocyte antigen (HLA) registries and umbilical cord blood banks have carried 
      out diligent searches to find matched unrelated donors (MUDs) for about 70.0% of 
      patients from 2000 onwards. The chance of finding a non-sibling fully matched 
      family donors is higher in some ethnic groups in which consanguineous marriages 
      are common. We have studied and compared transplant complications and outcomes in 
      different graft types (sibling, non-sibling family and unrelated). The 
      non-sibling matched family donor (MFD) group consisted of four mothers, three 
      fathers, five cousins, one paternal uncle and one paternal aunt. There was no 
      significant difference in the mean transfused CD34+ cells, engraftment, median 
      days of neutrophil and platelet recovery were achieved (p > 0.05). The 
      distribution of postttransplant complication did not show any significant 
      difference between groups (p > 0.05). In univariate analysis and multivarite 
      analyses, age, gender, Pesaro risk group (I-II vs. III) and ABO incompatibilty 
      demonstrated a significant difference in disease free survival (p < 0.05). 
      Furthermore, in the second step of investigating overall survival (OS), age, 
      gender and Pesaro risk group (I-II vs. III) showed a significant difference 
      (p < 0.05). There was no significant difference in transplant-related mortality 
      (TRM) between groups. Non-sibling related donor transplants are important for 
      populations where consanguineous marriages are common. Transplant groups 
      according to graft type had similar thalassemia-free survival (TFS) and OS when 
      using a treosulfan-based regimen in our study.
FAU - Aydogdu, Selime
AU  - Aydogdu S
AUID- ORCID: 0000-0003-3380-3080
AD  - Department of Pediatrics, Faculty of Medicine, Pediatric Bone Marrow 
      Transplantation Unit, Bahcelievler Medical Park Hospital, Altinbas University, 
      Istanbul, Turkey.
FAU - Toret, Ersin
AU  - Toret E
AUID- ORCID: 0000-0002-6379-8326
AD  - Department of Pediatrics, Faculty of Medicine, Pediatric Bone Marrow 
      Transplantation Unit, Bahcelievler Medical Park Hospital, Altinbas University, 
      Istanbul, Turkey.
FAU - Aksoy, Basak A
AU  - Aksoy BA
AUID- ORCID: 0000-0001-8338-2101
AD  - Department of Pediatrics, Faculty of Medicine, Pediatric Bone Marrow 
      Transplantation Unit, Bahcelievler Medical Park Hospital, Altinbas University, 
      Istanbul, Turkey.
AD  - Department of Pediatrics, Faculty of Medicine, Istinye University, Istanbul, 
      Turkey.
FAU - Aydin, Muhammed Fatih
AU  - Aydin MF
AUID- ORCID: 0000-0001-6056-9360
AD  - Department of Pediatrics, Faculty of Medicine, Pediatric Bone Marrow 
      Transplantation Unit, Bahcelievler Medical Park Hospital, Altinbas University, 
      Istanbul, Turkey.
FAU - Cipe, Funda E
AU  - Cipe FE
AUID- ORCID: 0000-0002-9718-7507
AD  - Department of Pediatrics, Faculty of Medicine, Pediatric Bone Marrow 
      Transplantation Unit, Bahcelievler Medical Park Hospital, Altinbas University, 
      Istanbul, Turkey.
FAU - Bozkurt, Ceyhun
AU  - Bozkurt C
AUID- ORCID: 0000-0001-6771-9894
AD  - Department of Pediatrics, Faculty of Medicine, Pediatric Bone Marrow 
      Transplantation Unit, Bahcelievler Medical Park Hospital, Altinbas University, 
      Istanbul, Turkey.
AD  - Department of Pediatrics, Faculty of Medicine, Istinye University, Istanbul, 
      Turkey.
FAU - Fisgin, Tunc
AU  - Fisgin T
AUID- ORCID: 0000-0003-4467-9935
AD  - Department of Pediatrics, Faculty of Medicine, Pediatric Bone Marrow 
      Transplantation Unit, Bahcelievler Medical Park Hospital, Altinbas University, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210121
PL  - England
TA  - Hemoglobin
JT  - Hemoglobin
JID - 7705865
SB  - IM
MH  - Family
MH  - Fetal Blood
MH  - *Graft vs Host Disease
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *beta-Thalassemia/therapy
OTO - NOTNLM
OT  - Hematopoietic stem cell transplantation (HSCT)
OT  - non-sibling family donor
OT  - pediatrics
OT  - thalassemia
OT  - treosulfan
EDAT- 2021/01/23 06:00
MHDA- 2021/12/18 06:00
CRDT- 2021/01/22 05:43
PHST- 2021/01/23 06:00 [pubmed]
PHST- 2021/12/18 06:00 [medline]
PHST- 2021/01/22 05:43 [entrez]
AID - 10.1080/03630269.2021.1872611 [doi]
PST - ppublish
SO  - Hemoglobin. 2021 Jan;45(1):25-29. doi: 10.1080/03630269.2021.1872611. Epub 2021 
      Jan 21.