PMID- 33480088
OWN - NLM
STAT- MEDLINE
DCOM- 20211109
LR  - 20211109
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 35
IP  - 4
DP  - 2021 Apr
TI  - Establishment of age- and sex-specific reference intervals for serum liver 
      function tests in pediatric population aged 1-<18 years: A prospective study.
PG  - e23708
LID - 10.1002/jcla.23708 [doi]
LID - e23708
AB  - BACKGROUND: The diagnosis, treatment, and prognosis of pediatric diseases rely on 
      the accurate establishment of the reference interval (RI). This study aimed to 
      establish pediatric RIs for liver function tests and evaluated the correlation of 
      the analytes. METHODS: Pediatric population (aged 1-<18 years) was prospectively 
      recruited in Jilin Province, China. Analytes detected by Ortho VITORS 5600 
      automatic biochemical analyzer. All strata were divided using the regression tree 
      and Harris and Boyd's method. The dynamic changes of RI were evaluated by the 
      lambda-mu-sigma method. RESULTS: Reference individuals were comprised of 6,322 
      children and adolescents. Age and sex differences were present in all analytes 
      except serum total protein. The serum albumin, total protein, gamma-glutamyl 
      transferase, total bilirubin, and unconjugated bilirubin levels increased with 
      age while serum aspartate aminotransferase was opposite. The serum alanine 
      aminotransferase level reached a trough at the age of 5 and later steadily in 
      males but slowly decreased in females. The serum alkaline phosphatase level 
      dropped rapidly after reaching a peak at 9 years old in females and 12 years old 
      in males. RIs were divided into 11 partitions at most and 5 partitions at least. 
      The strongest correlation between analytes was total bilirubin and unconjugated 
      bilirubin (r = 0.788), followed by total bilirubin and albumin (r = 0.511). 
      CONCLUSIONS: Analytes show unique dynamic changes in pediatric population. The 
      correlations among liver function tests can inform future studies of particular 
      variables. Age- and sex-special pediatric RIs should be established to help an 
      accurate diagnosis of disease.
CI  - (c) 2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley 
      Periodicals LLC.
FAU - Zhu, Xuetong
AU  - Zhu X
AUID- ORCID: 0000-0003-2502-8117
AD  - Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, 
      China.
FAU - Wang, Kaijin
AU  - Wang K
AUID- ORCID: 0000-0001-5158-8033
AD  - Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, 
      China.
FAU - Zhou, Qi
AU  - Zhou Q
AUID- ORCID: 0000-0002-5084-8697
AD  - Department of Pediatrics, First Hospital of Jilin University, Changchun, China.
FAU - Xu, Jiancheng
AU  - Xu J
AUID- ORCID: 0000-0001-8796-271X
AD  - Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, 
      China.
LA  - eng
GR  - JDYYZH-1902002/First Hospital Translational Funding for Scientific &Technological 
      Achievements/
GR  - 20170623092TC-09/Jilin Science and Technology Development Program/
GR  - 20190304110YY/Jilin Science and Technology Development Program/
GR  - 20200404171YY/Jilin Science and Technology Development Program/
PT  - Journal Article
DEP - 20210122
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Liver Function Tests
MH  - Prospective Studies
MH  - Reference Values
MH  - Serum/*metabolism
MH  - *Sex Characteristics
MH  - Statistics, Nonparametric
PMC - PMC8059739
OTO - NOTNLM
OT  - adolescent
OT  - alkaline phosphatase
OT  - children
OT  - liver function
OT  - reference interval
COIS- The authors stated that there are no conflicts of interest regarding the 
      publication of this article.
EDAT- 2021/01/23 06:00
MHDA- 2021/11/10 06:00
PMCR- 2021/01/22
CRDT- 2021/01/22 06:30
PHST- 2021/01/06 00:00 [revised]
PHST- 2020/11/18 00:00 [received]
PHST- 2021/01/07 00:00 [accepted]
PHST- 2021/01/23 06:00 [pubmed]
PHST- 2021/11/10 06:00 [medline]
PHST- 2021/01/22 06:30 [entrez]
PHST- 2021/01/22 00:00 [pmc-release]
AID - JCLA23708 [pii]
AID - 10.1002/jcla.23708 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2021 Apr;35(4):e23708. doi: 10.1002/jcla.23708. Epub 2021 Jan 
      22.