PMID- 33481189 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210831 IS - 1869-6953 (Print) IS - 1869-6961 (Electronic) IS - 1869-6961 (Linking) VI - 12 IP - 5 DP - 2021 May TI - Baseline HbA1c Level Influences the Effect of Periodontal Therapy on Glycemic Control in People with Type 2 Diabetes and Periodontitis: A Systematic Review on Randomized Controlled Trails. PG - 1249-1278 LID - 10.1007/s13300-021-01000-6 [doi] AB - INTRODUCTION: The question of whether periodontal therapy is an effective strategy for achieving glycemic control in people with type 2 diabetes mellitus (T2DM) and periodontitis continues to be open to debate. To clarify this issue, we conducted a systematic review and meta-analysis. METHODS: A systematic literature search of randomized controlled trials (RCTs) was carried out by searching four electronic databases and four journals up to April 2020. RCTs that evaluated the effect of periodontal therapy on glycemic control in people with T2DM were included. RESULTS: A total of 23 RCTs were included in this systematic review and meta-analysis. We found that after 3 and 6 months, periodontal therapy could significantly reduce glycosylated hemoglobin (HbA1c) level (3-month: weighted mean difference [WMD] - 0.514, 95% confidence interval [CI] - 0.730, - 0.298, p = 0.000; 6-month: WMD - 0.548, 95% CI - 0.859, - 0.238, p = 0.000). However, huge heterogeneity existed. Further analyses on 11 potential sources of heterogeneity found that baseline HbA1c of the included studies was the most significant factor causing heterogeneity. The benefit of periodontal therapy on glycemic control was much more obvious in studies with a higher baseline HbA1c level than in those with a lower baseline HbA1c level. CONCLUSIONS: Periodontal therapy significantly contributed to glycemic control in T2DM patients, especially in patients with higher baseline HbA1c level. FAU - Chen, Ya-Fei AU - Chen YF AD - State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. AD - Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Zhan, Qi AU - Zhan Q AD - State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. 2016151642005@stu.scu.edu.cn. AD - Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. 2016151642005@stu.scu.edu.cn. FAU - Wu, Chen-Zhou AU - Wu CZ AD - State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. AD - Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Yuan, Yi-Hang AU - Yuan YH AD - State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. AD - Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Chen, Wen AU - Chen W AD - State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. AD - Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Yu, Fan-Yuan AU - Yu FY AD - State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. AD - Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Li, Yi AU - Li Y AD - State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. AD - Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Li, Long-Jiang AU - Li LJ AUID- ORCID: 0000-0002-1494-9693 AD - State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. lilongjiang63@163.com. AD - Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, China. lilongjiang63@163.com. LA - eng GR - 81972538/Innovative Research Group Project of the National Natural Science Foundation of China/ GR - 81972546/Innovative Research Group Project of the National Natural Science Foundation of China/ GR - 81672669/Innovative Research Group Project of the National Natural Science Foundation of China (CN)/ GR - 2018YJSY106/Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System/ PT - Journal Article DEP - 20210122 PL - United States TA - Diabetes Ther JT - Diabetes therapy : research, treatment and education of diabetes and related disorders JID - 101539025 EIN - Diabetes Ther. 2021 Mar 27;:. PMID: 33774806 PMC - PMC8099950 OTO - NOTNLM OT - Blood glucose OT - Diabetes mellitus, type 2 OT - Meta-analysis OT - Periodontitis OT - Scaling and root planing OT - Systematic review EDAT- 2021/01/23 06:00 MHDA- 2021/01/23 06:01 PMCR- 2021/01/22 CRDT- 2021/01/22 12:18 PHST- 2020/11/28 00:00 [received] PHST- 2021/01/06 00:00 [accepted] PHST- 2021/01/23 06:00 [pubmed] PHST- 2021/01/23 06:01 [medline] PHST- 2021/01/22 12:18 [entrez] PHST- 2021/01/22 00:00 [pmc-release] AID - 10.1007/s13300-021-01000-6 [pii] AID - 1000 [pii] AID - 10.1007/s13300-021-01000-6 [doi] PST - ppublish SO - Diabetes Ther. 2021 May;12(5):1249-1278. doi: 10.1007/s13300-021-01000-6. Epub 2021 Jan 22.