PMID- 33481643
OWN - NLM
STAT- MEDLINE
DCOM- 20211025
LR  - 20220204
IS  - 1545-3278 (Electronic)
IS  - 0732-0582 (Linking)
VI  - 39
DP  - 2021 Apr 26
TI  - Dendritic Cells Revisited.
PG  - 131-166
LID - 10.1146/annurev-immunol-061020-053707 [doi]
AB  - Dendritic cells (DCs) possess the ability to integrate information about their 
      environment and communicate it to other leukocytes, shaping adaptive and innate 
      immunity. Over the years, a variety of cell types have been called DCs on the 
      basis of phenotypic and functional attributes. Here, we refocus attention on 
      conventional DCs (cDCs), a discrete cell lineage by ontogenetic and gene 
      expression criteria that best corresponds to the cells originally described in 
      the 1970s. We summarize current knowledge of mouse and human cDC subsets and 
      describe their hematopoietic development and their phenotypic and functional 
      attributes. We hope that our effort to review the basic features of cDC biology 
      and distinguish cDCs from related cell types brings to the fore the remarkable 
      properties of this cell type while shedding some light on the seemingly 
      inordinate complexity of the DC field.
FAU - Cabeza-Cabrerizo, Mar
AU  - Cabeza-Cabrerizo M
AD  - Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, United 
      Kingdom; email: caetano@crick.ac.uk.
FAU - Cardoso, Ana
AU  - Cardoso A
AD  - Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, United 
      Kingdom; email: caetano@crick.ac.uk.
FAU - Minutti, Carlos M
AU  - Minutti CM
AD  - Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, United 
      Kingdom; email: caetano@crick.ac.uk.
FAU - Pereira da Costa, Mariana
AU  - Pereira da Costa M
AD  - Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, United 
      Kingdom; email: caetano@crick.ac.uk.
FAU - Reis e Sousa, Caetano
AU  - Reis e Sousa C
AD  - Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, United 
      Kingdom; email: caetano@crick.ac.uk.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - CRUK_/Cancer Research UK/United Kingdom
GR  - MRC_/Medical Research Council/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210122
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
SB  - IM
MH  - Animals
MH  - Cell Lineage
MH  - *Dendritic Cells
MH  - Humans
MH  - *Immunity, Innate
MH  - Mice
OTO - NOTNLM
OT  - Langerhans cells
OT  - adaptive immunity
OT  - dendritic cells
OT  - innate immunity
OT  - monocytes
OT  - myelopoiesis
EDAT- 2021/01/23 06:00
MHDA- 2021/10/26 06:00
CRDT- 2021/01/22 17:11
PHST- 2021/01/23 06:00 [pubmed]
PHST- 2021/10/26 06:00 [medline]
PHST- 2021/01/22 17:11 [entrez]
AID - 10.1146/annurev-immunol-061020-053707 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2021 Apr 26;39:131-166. doi: 
      10.1146/annurev-immunol-061020-053707. Epub 2021 Jan 22.