PMID- 33483179 OWN - NLM STAT- MEDLINE DCOM- 20211221 LR - 20211221 IS - 0929-6646 (Print) IS - 0929-6646 (Linking) VI - 121 IP - 1 Pt 1 DP - 2022 Jan TI - The prevalence and clinical features of chronic obstructive pulmonary disease patients with traits of asthma in Taiwan. PG - 25-35 LID - S0929-6646(21)00020-6 [pii] LID - 10.1016/j.jfma.2021.01.003 [doi] AB - BACKGROUND/PURPOSE: The application of the checkbox for identifying patients with traits of both chronic obstructive pulmonary disease (COPD) and asthma proposed by the 2015 Global Initiative for Asthma (GINA)/Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommendations has not been well studied although such identification is important in clinical practice. Thus, we aimed to investigate the prevalence and features of COPD coexistent with asthma traits diagnosed based on the 2015 GINA/GOLD strategies, and explore the gap between guidelines and routine practice in the diagnosis and pharmacological management of such condition in a COPD cohort. METHODS: COPD subjects were enrolled retrospectively throughout Taiwan. A patient record form was completed for each participant and the data were analyzed. RESULTS: Of 340 participants, the prevalence of COPD coexistent with traits of asthma was 39.4% and 30.3% based on guidelines and physician's judgment, respectively. Coexistent patients were characterized by blood eosinophilia, higher total immunoglobulin E (IgE) levels, preserved lung function, and the presence of gastro-esophageal reflux disease and atopic disease while total IgE level > 100 kU/L and the presence of atopic disease were predictors for coexistent patients. Gaps existed in the diagnosis (a weak agreement with kappa = 0.53) and treatment (non-adherence to the preferred therapy in 18.4% of physician-judged coexistent patients) in COPD patients with asthma traits. The exacerbation history was similar between coexistent and non-coexistent patients. CONCLUSION: We found that measuring circulatory eosinophil and total IgE levels may raise clinicians' awareness of the presence of traits of asthma in the management of COPD. CI - Copyright (c) 2021. Published by Elsevier B.V. FAU - Huang, Wei-Chang AU - Huang WC AD - Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, 407, Taiwan; Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, 356, Taiwan; Department of Industrial Engineering and Enterprise Information, Tunghai University, Taichung, 407, Taiwan; Ph.D. Program in Translational Medicine, National Chung-Hsing University, Taichung, 402, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, 402, Taiwan. Electronic address: huangweichangtw@gmail.com. FAU - Sheu, Chau-Chyun AU - Sheu CC AD - Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan; Graduate Institute of Clinical Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan. Electronic address: sheucc@gmail.com. FAU - Hsu, Jeng-Yuan AU - Hsu JY AD - Division of Clinical Research, Department of Medical Research, Taichung Veterans General Hospital, Taichung, 407, Taiwan; School of Medicine, China Medical University, Taichung, 404, Taiwan; School of Physical Therapy, Chung-Shan Medical University, Taichung, 402, Taiwan. Electronic address: hsujy@vghtc.gov.tw. FAU - Perng, Diahn-Warng AU - Perng DW AD - Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, 112, Taiwan. Electronic address: dwperng@vghtpe.gov.tw. FAU - Wang, Hao-Chien AU - Wang HC AD - Division of Chest Medicine, Department of Internal Medicine, National Taiwan University Hospital, Taipei, 100, Taiwan; College of Medicine, National Taiwan University, Taipei, 100, Taiwan. Electronic address: haochienwang@gmail.com. FAU - Cheng, Shih-Lung AU - Cheng SL AD - Division of Chest Medicine, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei, 220, Taiwan; Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan, 320, Taiwan. Electronic address: shihlungcheng@gmail.com. FAU - Chen, Ben Cheng-Pin AU - Chen BC AD - AstraZeneca Taiwan, Taipei, 106, Taiwan. Electronic address: ben.chen@astrazeneca.com. LA - eng PT - Journal Article DEP - 20210120 PL - Singapore TA - J Formos Med Assoc JT - Journal of the Formosan Medical Association = Taiwan yi zhi JID - 9214933 SB - IM MH - *Asthma/epidemiology MH - Humans MH - Prevalence MH - *Pulmonary Disease, Chronic Obstructive/complications/epidemiology MH - Retrospective Studies MH - Taiwan/epidemiology OTO - NOTNLM OT - COPD OT - Clinical practice OT - GINA/GOLD guidelines OT - Traits of asthma COIS- Declaration of competing interest CPC is the employee of AstraZeneca Taiwan. The authors, WCH, CCS, JYH, DWP, HCW and SLC declare receiving lecture fees and consultancy fees from AstraZeneca Taiwan. This work was funded by AstraZeneca Taiwan in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3). Data underlying the findings described in this manuscript may be obtained in accordance with AstraZeneca's data sharing policy described at https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. EDAT- 2021/01/24 06:00 MHDA- 2021/12/22 06:00 CRDT- 2021/01/23 05:31 PHST- 2020/06/02 00:00 [received] PHST- 2020/11/22 00:00 [revised] PHST- 2021/01/05 00:00 [accepted] PHST- 2021/01/24 06:00 [pubmed] PHST- 2021/12/22 06:00 [medline] PHST- 2021/01/23 05:31 [entrez] AID - S0929-6646(21)00020-6 [pii] AID - 10.1016/j.jfma.2021.01.003 [doi] PST - ppublish SO - J Formos Med Assoc. 2022 Jan;121(1 Pt 1):25-35. doi: 10.1016/j.jfma.2021.01.003. Epub 2021 Jan 20.