PMID- 33483468
OWN - NLM
STAT- MEDLINE
DCOM- 20210923
LR  - 20221207
IS  - 2044-4052 (Electronic)
IS  - 2044-4052 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Jan 22
TI  - The relationship between different C-peptide level and insulin dose of insulin 
      pump.
PG  - 7
LID - 10.1038/s41387-020-00148-7 [doi]
LID - 7
AB  - BACKGROUND: This study aims to explore the insulin requirement profiles, and 
      analyze the related factors of type-2 diabetes mellitus (T2DM) with different 
      C-peptide levels on insulin pump therapy. METHODS: A retrospective study was 
      conducted on 271 T2DM patients treated with insulin pumps from 2016 to 2018. 
      These patients were divided into groups according to the ratio of C-peptide at 
      2 h after meals to fasting C-peptide (C(2)h/C(0)), and the dosage of insulin and 
      influencing factors were analyzed. RESULTS: In comparing group A 
      (C(2h)/C(0) < 2.5) with group B (C(2h)/C(0) >/= 2.5), the percentage of the base 
      amount in total (%TBa, 0.50 +/- 0.06) in group A was higher than that in group B 
      (0.48 +/- 0.05) (P < 0.05). Furthermore, there was a correlation between C(2h)/C(0) 
      and waist circumference, HbA1c, Fasting Plasma Glucose (FPG) and Blood glucose 
      2 h after meal (2hPG) (r = -0.137, -0.154, -0.471, and -0.172; all, P < 0.05). 
      The multiple linear regression analysis revealed that BMI and FPG were 
      independent factors of %TBa (beta' = 0.124 and 0.144; all, P < 0.05), and BMI and 
      FPG were independent factors of C(2h)/C(0) (beta' = -0.134 and -0.502; all, 
      P < 0.05). CONCLUSIONS: The basal premeal dose ratio of T2DM with different 
      C-peptide levels differs during intensive insulin pump therapy. Parameters that 
      indicate the glycemic control and beta-cell function should be taken into 
      consideration for total insulin requirements.
FAU - Wei, Yihan
AU  - Wei Y
AD  - State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence 
      Diseases in Central Asia; Department of Endocrinology, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, 830017, China.
FAU - Quan, Li
AU  - Quan L
AD  - State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence 
      Diseases in Central Asia; Department of Endocrinology, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, 830017, China.
FAU - Zhou, Ting
AU  - Zhou T
AD  - State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence 
      Diseases in Central Asia; Department of Endocrinology, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, 830017, China.
FAU - Du, Guoli
AU  - Du G
AD  - State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence 
      Diseases in Central Asia; Department of Endocrinology, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, 830017, China.
FAU - Jiang, Sheng
AU  - Jiang S
AUID- ORCID: 0000-0002-2064-3279
AD  - State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence 
      Diseases in Central Asia; Department of Endocrinology, The First Affiliated 
      Hospital of Xinjiang Medical University, Urumqi, 830017, China. 
      jiangshengdr_88@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210122
PL  - England
TA  - Nutr Diabetes
JT  - Nutrition & diabetes
JID - 101566341
RN  - 0 (Blood Glucose)
RN  - 0 (C-Peptide)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - C-Peptide/*blood
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy
MH  - Fasting
MH  - Female
MH  - Glucose Tolerance Test
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Insulin/*administration & dosage
MH  - *Insulin Infusion Systems
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Waist Circumference
PMC - PMC7822886
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/01/24 06:00
MHDA- 2021/09/24 06:00
PMCR- 2021/01/22
CRDT- 2021/01/23 05:34
PHST- 2020/06/15 00:00 [received]
PHST- 2020/12/17 00:00 [accepted]
PHST- 2020/12/16 00:00 [revised]
PHST- 2021/01/23 05:34 [entrez]
PHST- 2021/01/24 06:00 [pubmed]
PHST- 2021/09/24 06:00 [medline]
PHST- 2021/01/22 00:00 [pmc-release]
AID - 10.1038/s41387-020-00148-7 [pii]
AID - 148 [pii]
AID - 10.1038/s41387-020-00148-7 [doi]
PST - epublish
SO  - Nutr Diabetes. 2021 Jan 22;11(1):7. doi: 10.1038/s41387-020-00148-7.