PMID- 33483485
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210130
IS  - 2334-265X (Print)
IS  - 2334-265X (Electronic)
IS  - 2334-265X (Linking)
VI  - 7
IP  - 1
DP  - 2021 Jan 22
TI  - Negative symptoms and speech pauses in youths at clinical high risk for 
      psychosis.
PG  - 3
LID - 10.1038/s41537-020-00132-1 [doi]
LID - 3
AB  - Aberrant pauses are characteristic of schizophrenia and are robustly associated 
      with its negative symptoms. Here, we found that pause behavior was associated 
      with negative symptoms in individuals at clinical high risk (CHR) for psychosis, 
      and with measures of syntactic complexity-phrase length and usage of determiners 
      that introduce clauses-that we previously showed in this same CHR cohort to help 
      comprise a classifier that predicted psychosis. These findings suggest a common 
      impairment in discourse planning and verbal self-monitoring that affects both 
      speech and language, and which is detected in clinical ratings of negative 
      symptoms.
FAU - Stanislawski, Emma R
AU  - Stanislawski ER
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Bilgrami, Zarina R
AU  - Bilgrami ZR
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Sarac, Cansu
AU  - Sarac C
AUID- ORCID: 0000-0003-3819-5918
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Garg, Sahil
AU  - Garg S
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Heisig, Stephen
AU  - Heisig S
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA.
FAU - Cecchi, Guillermo A
AU  - Cecchi GA
AUID- ORCID: 0000-0003-1013-8348
AD  - IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
FAU - Agurto, Carla
AU  - Agurto C
AD  - IBM T.J. Watson Research Center, Yorktown Heights, NY, USA.
FAU - Corcoran, Cheryl M
AU  - Corcoran CM
AUID- ORCID: 0000-0002-8902-4353
AD  - Icahn School of Medicine at Mount Sinai, New York, NY, USA. 
      Cheryl.corcoran@mssm.edu.
AD  - James J. Peters VA Medical Center, Bronx, NY, USA. Cheryl.corcoran@mssm.edu.
LA  - eng
PT  - Journal Article
DEP - 20210122
PL  - United States
TA  - NPJ Schizophr
JT  - NPJ schizophrenia
JID - 101657919
PMC - PMC7822906
COIS- The authors declare no competing interests.
EDAT- 2021/01/24 06:00
MHDA- 2021/01/24 06:01
PMCR- 2021/01/22
CRDT- 2021/01/23 05:34
PHST- 2020/06/18 00:00 [received]
PHST- 2020/11/24 00:00 [accepted]
PHST- 2021/01/23 05:34 [entrez]
PHST- 2021/01/24 06:00 [pubmed]
PHST- 2021/01/24 06:01 [medline]
PHST- 2021/01/22 00:00 [pmc-release]
AID - 10.1038/s41537-020-00132-1 [pii]
AID - 132 [pii]
AID - 10.1038/s41537-020-00132-1 [doi]
PST - epublish
SO  - NPJ Schizophr. 2021 Jan 22;7(1):3. doi: 10.1038/s41537-020-00132-1.