PMID- 33483717 OWN - NLM STAT- MEDLINE DCOM- 20210506 LR - 20240401 IS - 1471-0048 (Electronic) IS - 1471-003X (Print) IS - 1471-003X (Linking) VI - 22 IP - 3 DP - 2021 Mar TI - The default mode network: where the idiosyncratic self meets the shared social world. PG - 181-192 LID - 10.1038/s41583-020-00420-w [doi] AB - The default mode network (DMN) is classically considered an 'intrinsic' system, specializing in internally oriented cognitive processes such as daydreaming, reminiscing and future planning. In this Perspective, we suggest that the DMN is an active and dynamic 'sense-making' network that integrates incoming extrinsic information with prior intrinsic information to form rich, context-dependent models of situations as they unfold over time. We review studies that relied on naturalistic stimuli, such as stories and movies, to demonstrate how an individual's DMN neural responses are influenced both by external information accumulated as events unfold over time and by the individual's idiosyncratic past memories and knowledge. The integration of extrinsic and intrinsic information over long timescales provides a space for negotiating a shared neural code, which is necessary for establishing shared meaning, shared communication tools, shared narratives and, above all, shared communities and social networks. FAU - Yeshurun, Yaara AU - Yeshurun Y AD - School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel. yaaray@tauex.tau.ac.il. AD - Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel. yaaray@tauex.tau.ac.il. FAU - Nguyen, Mai AU - Nguyen M AD - School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel. AD - Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel. AD - Department of Psychology, Princeton University, Princeton, NJ, USA. AD - Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. FAU - Hasson, Uri AU - Hasson U AD - School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel. hasson@princeton.edu. AD - Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel. hasson@princeton.edu. AD - Department of Psychology, Princeton University, Princeton, NJ, USA. hasson@princeton.edu. AD - Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. hasson@princeton.edu. LA - eng GR - DP1 HD091948/HD/NICHD NIH HHS/United States GR - R01 MH112566/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Review DEP - 20210122 PL - England TA - Nat Rev Neurosci JT - Nature reviews. Neuroscience JID - 100962781 SB - IM MH - Animals MH - Cognition/physiology MH - Communication MH - Default Mode Network/*physiology MH - *Ego MH - Humans MH - Nerve Net/*physiology MH - Nervous System Physiological Phenomena MH - Neural Pathways/physiology PMC - PMC7959111 MID - NIHMS1677334 COIS- Competing interests The authors declare no competing interests. EDAT- 2021/01/24 06:00 MHDA- 2021/05/07 06:00 PMCR- 2021/03/15 CRDT- 2021/01/23 05:38 PHST- 2020/12/10 00:00 [accepted] PHST- 2021/01/24 06:00 [pubmed] PHST- 2021/05/07 06:00 [medline] PHST- 2021/01/23 05:38 [entrez] PHST- 2021/03/15 00:00 [pmc-release] AID - 10.1038/s41583-020-00420-w [pii] AID - 10.1038/s41583-020-00420-w [doi] PST - ppublish SO - Nat Rev Neurosci. 2021 Mar;22(3):181-192. doi: 10.1038/s41583-020-00420-w. Epub 2021 Jan 22.