PMID- 33484245
OWN - NLM
STAT- MEDLINE
DCOM- 20210929
LR  - 20210929
IS  - 1944-7922 (Electronic)
IS  - 1060-3271 (Linking)
VI  - 104
IP  - 5
DP  - 2021 Sep 27
TI  - Spectrophotometric Determination of Polyvinyl Pyrrolidone in Pure and 
      Pharmaceutical Dosage Form.
PG  - 1420-1429
LID - 10.1093/jaoacint/qsaa177 [doi]
AB  - BACKGROUND: Recently, functional polymers have attracted significant attention in 
      the areas of pharmaceuticals and biomedical applications, so it is important to 
      develop simple techniques to analyze functional polymers in their pharmaceutical 
      dosage forms. OBJECTIVE: Three simple, accurate, and sensitive UV 
      spectrophotometric methods have been developed and validated for determination of 
      polyvinyl pyrrolidone (PVP) in the presence of benzalkonium chloride (BZ) and 
      sodium lactate in ternary mixtures. METHOD: Method A is a derivative ratio 
      spectra zero-crossing (DRSZ) method which measures PVP peak amplitude at 
      303.1 nm. Method B is a double divisor ratio derivative (DDRD), used for 
      determination of both PVP and BZ in the presence of sodium lactate at 272.6 and 
      271.5 nm, respectively. Method C is a double divisor ratio derivative-ratio 
      difference spectrophotometric method (DDRD-RDSM), a new and hybrid method of 
      double divisor and ratio difference that hasn't been applied before. It measures 
      peak amplitude difference of the ratio spectra at DeltaP278 - 252.4 and DeltaP260.9 - 213 
      for PVP and BZ, respectively. RESULTS: Linear ranges for PVP (5.00-35.00, 
      10.00-40.00, and 10.00-40.00 microg/mL) was obtained by using DRSZ, DDRD, and 
      DDRD-RDSM, respectively. While the linear range for BZ (5.00-60 microg/mL) was 
      obtained by using both DDRD and DDRD-RDSM. CONCLUSIONS: All results were 
      statistically compared with reported methods. No significant differences were 
      observed. The developed methods were applied to the analysis of the investigated 
      drugs in pure and pharmaceutical dosage forms. HIGHLIGHTS: The proposed methods 
      are of great value, improving the efficiency of routine analysis of PVP and BZ in 
      their pharmaceutical dosage forms.
CI  - (c) AOAC INTERNATIONAL 2021. All rights reserved. For permissions, please email: 
      journals.permissions@oup.com.
FAU - Al-Afify, Nourhan Kh
AU  - Al-Afify NK
AD  - Ain Shams University, Faculty of Pharmacy, Department of Pharmaceutical 
      Analytical Chemistry, Organization of African Unity Street, Abassia, Cairo, 
      Egypt.
FAU - Trabik, Yossra A
AU  - Trabik YA
AD  - Ain Shams University, Faculty of Pharmacy, Department of Pharmaceutical 
      Analytical Chemistry, Organization of African Unity Street, Abassia, Cairo, 
      Egypt.
FAU - El-Kosasy, Amira M
AU  - El-Kosasy AM
AD  - Ain Shams University, Faculty of Pharmacy, Department of Pharmaceutical 
      Analytical Chemistry, Organization of African Unity Street, Abassia, Cairo, 
      Egypt.
FAU - Magdy, N
AU  - Magdy N
AD  - Ain Shams University, Faculty of Pharmacy, Department of Pharmaceutical 
      Analytical Chemistry, Organization of African Unity Street, Abassia, Cairo, 
      Egypt.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J AOAC Int
JT  - Journal of AOAC International
JID - 9215446
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Polyvinyls)
RN  - FZ989GH94E (Povidone)
SB  - IM
MH  - *Pharmaceutical Preparations
MH  - *Polyvinyls
MH  - Povidone
MH  - Spectrophotometry
EDAT- 2021/01/24 06:00
MHDA- 2021/09/30 06:00
CRDT- 2021/01/23 12:05
PHST- 2020/10/01 00:00 [received]
PHST- 2020/11/15 00:00 [revised]
PHST- 2020/12/21 00:00 [accepted]
PHST- 2021/01/24 06:00 [pubmed]
PHST- 2021/09/30 06:00 [medline]
PHST- 2021/01/23 12:05 [entrez]
AID - 6116501 [pii]
AID - 10.1093/jaoacint/qsaa177 [doi]
PST - ppublish
SO  - J AOAC Int. 2021 Sep 27;104(5):1420-1429. doi: 10.1093/jaoacint/qsaa177.